Isocarboxazid
General information:
| Withdrawn ID: | w159 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | N06AF01 |
| Molecular Formula: | C12H13N3O2 |
| Molweight: | 231.251 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1959 |
| First withdrawn: | 1974 |
| Last withdrawn: | 1974 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/3731918 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Isocarboxazid as primary suspect: | 1 |
|---|
Reported final outcomes:
| Death: | 1 |
|---|
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Drug ineffective | 2 |
| Toxicity to various agents | 1 |
| Sleep disorder | 1 |
| Pain | 1 |
| Malaise | 1 |
| Insomnia | 1 |
| Hallucination, auditory | 1 |
| Feeling abnormal | 1 |
| Fatigue | 1 |
| Diarrhoea | 1 |
| Completed suicide | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P02545 | 3162.3 | Prelamin-A/C | LMNA_HUMAN |
Toxicity information:
| Toxicity class: | 3 |
|---|---|
| Toxicity type: | hepatic |
| LD50: | 141 mg/kg |
External links:
| ChEBML: | CHEMBL1201168 |
|---|---|
| DrugBank: | DB01247 |