Phenylbutazone
General information:
| Withdrawn ID: | w149 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | M01AA01 |
| Molecular Formula: | C19H20N2O2 |
| Molweight: | 308.374 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1980 |
| First death: | 1953 |
| First withdrawn: | 1985 |
| Last withdrawn: | 1985 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/20720197 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Phenylbutazone as primary suspect: | 7 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 4 |
|---|---|
| Death: | 2 |
| Life-Threatening condition: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Loss of consciousness | 2 |
| Blister | 2 |
| Pyrexia | 2 |
| Erythema multiforme | 1 |
| Embolia cutis medicamentosa | 1 |
| Extremity necrosis | 1 |
| Eye pain | 1 |
| Eyelid disorder | 1 |
| Eyelid oedema | 1 |
| General physical health deterioration | 1 |
| Gingival bleeding | 1 |
| Haematuria | 1 |
| Hyperaemia | 1 |
| Impaired healing | 1 |
| Incorrect route of drug administration | 1 |
| Injection site inflammation | 1 |
| Leukocytosis | 1 |
| Erythema | 1 |
| Agranulocytosis | 1 |
| Dyspnoea | 1 |
| Dry gangrene | 1 |
| Disease susceptibility | 1 |
| Dermatosis | 1 |
| Dermatitis bullous | 1 |
| Decreased appetite | 1 |
| Cyanosis | 1 |
| COMPLETED SUICIDE | 1 |
| Chills | 1 |
| C-reactive protein increased | 1 |
| Asthenia | 1 |
| Aspartate aminotransferase increased | 1 |
| Arteriosclerosis | 1 |
| Vomiting | 1 |
| Skin burning sensation | 1 |
| Tonsillitis | 1 |
| Telangiectasia | 1 |
| Swelling face | 1 |
| Suicide attempt | 1 |
| Streptococcal infection | 1 |
| Stevens-Johnson syndrome | 1 |
| Staphylococcal infection | 1 |
| Skin ulcer | 1 |
| Skin plaque | 1 |
| Skin necrosis | 1 |
| Skin lesion | 1 |
| Skin induration | 1 |
| Skin graft detachment | 1 |
| Skin fissures | 1 |
| Skin degenerative disorder | 1 |
| Liver injury | 1 |
| Scar | 1 |
| Scab | 1 |
| Renal disorder | 1 |
| Rash erythematous | 1 |
| Rash | 1 |
| Purpura | 1 |
| Pneumonia | 1 |
| Pain of skin | 1 |
| Pain in extremity | 1 |
| Overdose | 1 |
| Oral mucosa erosion | 1 |
| Oliguria | 1 |
| Nikolsky's sign | 1 |
| Melaena | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P00352 | 1122 | Retinal dehydrogenase 1 | AL1A1_HUMAN |
| P02545 | 10 | Prelamin-A/C | LMNA_HUMAN |
| P54132 | 0.3 | Bloom syndrome protein | BLM_HUMAN |
| Q16637 | 1584.9 | Survival motor neuron protein | SMN_HUMAN |
| Q6W5P4 | 316.2 | Neuropeptide S receptor | NPSR1_HUMAN |
| Q6XQN6 | 0.1 | Nicotinate phosphoribosyltransferase | PNCB_HUMAN |
| Q99714 | 3162.3 | 3-hydroxyacyl-CoA dehydrogenase type-2 | HCD2_HUMAN |
| Q9NUW8 | 891.3 | Tyrosyl-DNA phosphodiesterase 1 | TYDP1_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | hematological |
| LD50: | 727 mg/kg |
External links:
| ChEBML: | CHEMBL101 |
|---|---|
| DrugBank: | DB08343, DB00812 |