Amphetamine


w147



General information:


Withdrawn ID: w147
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N06BA01
Molecular Formula: C9H13N
Molweight: 135.206



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1955
First withdrawn: 2005
Last withdrawn: 2005
Reference: https://www.ncbi.nlm.nih.gov/pubmed/21842255



Side-effects:

Total reported cases (submitted by medical professionals) with Amphetamine as primary suspect: 1322


Reported final outcomes:
Death: 383
Hospitalization (initial or prolonged): 117
Life-Threatening condition: 20
Disability: 8
Intervention required to prevent permanent impairment/damage: 2
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
Drug abuse340
DRUG INEFFECTIVE338
TOXICITY TO VARIOUS AGENTS324
Prescribed overdose125
Completed suicide107
PRODUCT QUALITY ISSUE86
Off label use82
CARDIO-RESPIRATORY ARREST76
FEELING ABNORMAL70
No adverse event69
Inappropriate schedule of drug administration68
HEADACHE64
Disturbance in attention62
INSOMNIA60
Product availability issue59
PRODUCT SUBSTITUTION ISSUE58
FATIGUE57
ANXIETY56
Product physical issue50
Poisoning49
Cardiac arrest49
Product use issue42
Nausea40
Respiratory arrest38
Condition aggravated38
AGITATION37
Somnolence36
Inappropriate schedule of product administration36
ABNORMAL BEHAVIOUR36
AGGRESSION35
Depression34
Drug effect decreased31
Decreased appetite29
Exposure via ingestion28
Unevaluable event26
Product dispensing error26
IRRITABILITY26
DIZZINESS25
ANGER24
Palpitations23
Malaise22
HEART RATE INCREASED22
DRY MOUTH22
OVERDOSE21
Weight decreased20
TIC20
Therapeutic response shortened20
HYPERHIDROSIS20
Asthenia20
Rash19
PSYCHOMOTOR HYPERACTIVITY19
Pain19
Intentional product misuse19
Drug interaction18
Vomiting17
MOOD ALTERED17
Incorrect dose administered17
Inability to afford medication17
HYPERTENSION17
Feeling jittery17
Depressed mood17
DEATH17
Adverse drug reaction17
Wrong technique in product usage process16
Suicidal ideation16
SLEEP DISORDER16
Weight increased15
Urticaria15
TACHYCARDIA15
Seizure15
Insurance issue15
Impulsive behaviour15
FALL15
Drug intolerance15
Drug dose omission15
Adverse event15
WITHDRAWAL SYNDROME14
Tremor14
NERVOUSNESS14
Memory impairment14
MEDICATION ERROR14
Loss of consciousness14
DYSTONIA14
Dyspnoea14
Therapeutic product effect decreased13
Stress cardiomyopathy13
Blood pressure increased13
VISION BLURRED12
Therapeutic response unexpected12
Mood swings12
Crying12
Cardiogenic shock12
Abdominal pain upper12
Rhabdomyolysis11
Prescription drug used without a prescription11
Drug hypersensitivity11
Drug dispensing error11
DRUG DEPENDENCE11
PSYCHOTIC DISORDER10
Paranoia10
Migraine10
Internal injury10
Hypersensitivity10
Hallucination10
Drug effect variable10
Diarrhoea10
Confusional state10
Coma10
Chest pain10
Cardiomyopathy10
Suicide attempt9
Speech disorder9
Loss of personal independence in daily activities9
Lethargy9
Intentional overdose9
Hypoaesthesia9
Amphetamines positive9
Paraesthesia8
Metabolic acidosis8
MANIA8
Intestinal ischaemia8
Increased appetite8
IMPAIRED WORK ABILITY8
Erythema8
Dyskinesia8
Drug prescribing error8
Drug effect increased8
Cardiac failure8
VISUAL IMPAIRMENT7
Thinking abnormal7
Therapy interrupted7
Therapeutic product effect incomplete7
Product tampering7
Product dose omission issue7
Pain in extremity7
MENTAL DISORDER7
Intentional product use issue7
Ill-defined disorder7
HYPOTENSION7
Hallucination, auditory7
Exposure during pregnancy7
ENCEPHALOPATHY7
Educational problem7
Delusion7
Acute kidney injury7
Abdominal pain7
Abdominal discomfort7
Transcription medication error6
Therapeutic response decreased6
Swelling6
Road traffic accident6
Pruritus6
Personality change6
NERVOUS SYSTEM DISORDER6
Mydriasis6
Muscle spasms6
Maternal exposure during pregnancy6
Frustration tolerance decreased6
EUPHORIC MOOD6
Dyspepsia6
Drug diversion6
Drug administered to patient of inappropriate age6
Disturbance in social behaviour6
Arthralgia6
Apathy6
Treatment noncompliance5
Thrombocytopenia5
Therapeutic response changed5
Therapeutic product effect variable5
Tachyphrenia5
Substance use5
Raynaud's phenomenon5
Product taste abnormal5
Product storage error5
Product packaging quantity issue5
Product dose omission5
Panic attack5
Logorrhoea5
Intentional self-injury5
Illness5
Hypersomnia5
Hyperreflexia5
Hyperphagia5
Heart rate decreased5
Gait disturbance5
Feeling hot5
Fear5
Energy increased5
Emotional disorder5
Drug use disorder5
Drug effect less than expected5
Drug effect delayed5
Dermatillomania5
Depressed level of consciousness5
Delirium5
Dehydration5
Cerebrovascular accident5
Cerebral haemorrhage5
Brain oedema5
BLOOD CREATINE PHOSPHOKINASE INCREASED5
Alopecia5
Activities of daily living impaired5
Ventricular fibrillation4
Unresponsive to stimuli4
Therapy non-responder4
Therapy change4
Syncope4
Sluggishness4
Skin discolouration4
RESTLESSNESS4
Respiratory failure4
Pyrexia4
Product prescribing error4
Product label issue4
Potentiating drug interaction4
Pneumonia aspiration4
Peripheral ischaemia4
Paralysis4
Negativism4
Myalgia4
Mental impairment4
Impaired driving ability4
HYPERTHERMIA4
Hypersexuality4
Generalised tonic-clonic seizure4
Gastrointestinal disorder4
Electrocardiogram QT prolonged4
Dysstasia4
Dysphagia4
Dysarthria4
Drug withdrawal syndrome4
Drug tolerance4
Drug screen positive4
Drug effect incomplete4
COVID-194
Cough4
Coronary artery dissection4
Chest discomfort4
Change in sustained attention4
Bruxism4
Attention deficit/hyperactivity disorder4
Amphetamines negative4
Amnesia4
Affect lability4
Wrong product administered3
Visual acuity reduced3
Urine amphetamine positive3
Urinary incontinence3
Underdose3
Treatment failure3
Tongue disorder3
Tardive dyskinesia3
Swollen tongue3
Substance-induced psychotic disorder3
Substance abuse3
Stress3
Somatic delusion3
Skin ulcer3
Respiratory depression3
Product use in unapproved indication3
Product supply issue3
Product formulation issue3
Pregnancy3
Posterior reversible encephalopathy syndrome3
Post-traumatic stress disorder3
Physical assault3
Performance status decreased3
Penis disorder3
Pallor3
Nonspecific reaction3
No therapeutic response3
Neuralgia3
Neck pain3
Myocardial ischaemia3
Muscular weakness3
Muscle disorder3
Movement disorder3
Malabsorption3
Left ventricular dysfunction3
Intercepted product dispensing error3
Intentional drug misuse3
Hypoxia3
Hypophagia3
Hypoglycaemia3
Hospitalisation3
Hormone level abnormal3
Hepatotoxicity3
Gangrene3
FRUSTRATION3
Food allergy3
Fibromyalgia3
Feeling cold3
Feeding disorder3
EYE DISORDER3
Excessive masturbation3
Ear discomfort3
Dysgeusia3
Distractibility3
DISCOMFORT3
Dependence3
Dental caries3
Counterfeit product administered3
Coronary artery occlusion3
Coronary artery disease3
Constipation3
Congestive cardiomyopathy3
Colitis ischaemic3
Coeliac disease3
Cerebral disorder3
Central nervous system necrosis3
CARDIOVASCULAR DISORDER3
Cardiac disorder3
BRAIN INJURY3
Brain death3
Bladder disorder3
Atrial fibrillation3
Aortic dissection3
Alcohol interaction3
Affective disorder3
Accidental exposure to product by child3
Abdominal distension3
Yawning2
Wrong technique in drug usage process2
Wrong patient received product2
Wheezing2
Weight fluctuation2
Violence-related symptom2
Vertigo2
Vertebral artery dissection2
Vasodilatation2
Vasoconstriction2
Vascular pseudoaneurysm2
Vaginal haemorrhage2
Urine odour abnormal2
Troponin increased2
Tricuspid valve incompetence2
Thyrotoxic crisis2
Therapeutic response unexpected with drug substitution2
Therapeutic product effect prolonged2
Systemic lupus erythematosus2
Suspected suicide2
Spinal osteoarthritis2
Sleep deficit2
Skin disorder2
Sinusitis2
Sexual dysfunction2
Screaming2
Schizophrenia2
Retching2
Renal ischaemia2
Renal impairment2
RENAL FAILURE2
Rash macular2
Pupillary reflex impaired2
Pulse abnormal2
Pulmonary oedema2
Pulmonary arterial hypertension2
Pruritus generalised2
Product use complaint2
Product prescribing issue2
Product label confusion2
Product distribution issue2
Product colour issue2
Premature separation of placenta2
Premature baby2
Poor quality sleep2
Poor quality product administered2
Pollakiuria2
Pneumonitis chemical2
Physical product label issue2
Peripheral swelling2
Peripheral coldness2
Penile vein thrombosis2
Penile size reduced2
Penile abscess2
Parkinsonism2
Oropharyngeal pain2
Oral disorder2
Oral discomfort2
Oral administration complication2
Oppositional defiant disorder2
Oedema2
Ocular hyperaemia2
Obsessive-compulsive disorder2
Obsessive thoughts2
Nightmare2
Nicotine dependence2
Neuropathy peripheral2
Neurological symptom2
Necrosis2
Nasopharyngitis2
Myocardial infarction2
Multiple sclerosis2
Multiple organ dysfunction syndrome2
Multi-organ failure2
MENOPAUSE2
Maternal drugs affecting foetus2
Low birth weight baby2
Limb discomfort2
Libido increased2
Leukocytosis2
Laziness2
Joint injury2
Intercepted product prescribing error2
Initial insomnia2
Incorrect dosage administered2
Incoherent2
IMPRISONMENT2
Implantable defibrillator insertion2
Impaired quality of life2
Hyperthyroidism2
Hypermetabolism2
Homicidal ideation2
Hepatic steatosis2
Hepatic failure2
Heart rate abnormal2
Head discomfort2
Hallucination, visual2
Haematuria2
General physical health deterioration2
Gait inability2
Formication2
Foetal hypokinesia2
Foetal growth restriction2
Foetal exposure during pregnancy2
Eye irritation2
Extra dose administered2
Erection increased2
Erectile dysfunction2
Epistaxis2
Emotional distress2
Electrocardiogram QRS complex prolonged2
ECONOMIC PROBLEM2
Dysuria2
Dysphemia2
Drug withdrawal syndrome neonatal2
Drug titration error2
Drug effect prolonged2
Dissociation2
Disseminated intravascular coagulation2
Disability2
Dermatophagia2
Daydreaming2
Craniocerebral injury2
Coronary artery thrombosis2
Coordination abnormal2
Contusion2
Congenital central hypoventilation syndrome2
Compulsive sexual behaviour2
Cold sweat2
Cognitive disorder2
COAGULOPATHY2
Clonus2
Chromaturia2
Choreoathetosis2
Choking sensation2
Cerebral infarction2
Cerebellar infarction2
Cardiomegaly2
Cardiac failure congestive2
Cardiac failure acute2
Caesarean section2
Bronchopneumonia2
BLOOD PRESSURE DECREASED2
Blood pressure abnormal2
BLOOD POTASSIUM DECREASED2
Blood cholesterol increased2
Blister2
Bladder dilatation2
Bipolar disorder2
Behaviour disorder2
Bedridden2
Balance disorder2
Bacterial infection2
Back pain2
Autoscopy2
Asphyxia2
Appetite disorder2
Apnoea2
Aphthous ulcer2
Anion gap2
Anaemia2
Allergic reaction to excipient2
Akathisia2
Ageusia2
Adverse reaction2
Acute myocardial infarction2
Acute lung injury2
Acute hepatic failure2
Acne2
Accidental overdose2
Abnormal loss of weight2
Wrong dosage form1
Wound infection staphylococcal1
Wound1
White blood cell disorder1
White blood cell count increased1
Weight gain poor1
Vulvovaginal mycotic infection1
Vulvovaginal dryness1
Vulvovaginal discomfort1
Vitamin C deficiency1
Viral infection1
Victim of sexual abuse1
Victim of crime1
Victim of abuse1
Ventricular tachycardia1
Ventricular extrasystoles1
Ventricular dysfunction1
Uveitis1
Uterine prolapse1
Urine output decreased1
Urine flow decreased1
Urine abnormality1
Urinary tract infection1
Urinary tract discomfort1
Urinary retention1
Urinary hesitation1
Urethral injury1
Ureteric fistula1
Upper respiratory tract infection1
Tumour pain1
Transient ischaemic attack1
Transaminases increased1
Toxic leukoencephalopathy1
Tourette's disorder1
Toothache1
TOOTH INJURY1
Tooth fracture1
Tooth discolouration1
Tinnitus1
Tinea infection1
Thyroid disorder1
Throat tightness1
Thirst1
Thermal burn1
Therapy cessation1
Therapeutic product effect increased1
Theft1
Testicular swelling1
Testicular pain1
Tension1
Tearfulness1
Syringe issue1
Swelling face1
Suspiciousness1
Suspected suicide attempt1
Suspected product tampering1
Suspected counterfeit product1
Suicidal behaviour1
Sudden death1
Substance-induced mood disorder1
Subdural haematoma1
Stress fracture1
Stress at work1
Stevens-Johnson syndrome1
Squamous cell carcinoma1
Spontaneous penile erection1
Splenic rupture1
Spinal pain1
Spinal fracture1
Spinal cord injury cervical1
Spinal cord injury1
Spinal column stenosis1
Somnambulism1
Somatic symptom disorder1
Social anxiety disorder1
Slow speech1
Sleep apnoea syndrome1
Skin odour abnormal1
Skin lesion1
Skin abrasion1
Sinus disorder1
Serotonin syndrome1
Septic shock1
Sensation of foreign body1
Self-induced vomiting1
Self esteem decreased1
Seasonal allergy1
Scratch1
Scar1
Scab1
Saliva altered1
Romberg test positive1
Rhinorrhoea1
Restless legs syndrome1
Respiratory paralysis1
Respiratory disorder1
Respiratory acidosis1
Repetitive speech1
Regurgitation1
Rebound effect1
READING DISORDER1
Reaction to sweetener1
Rash pruritic1
Rash generalised1
Pupils unequal1
Pupillary disorder1
Pulmonary hypertension1
Pulmonary congestion1
Psychiatric symptom1
Psoriatic arthropathy1
Prolactinoma1
Progesterone increased1
Product temperature excursion issue1
Product solubility abnormal1
Product selection error1
Product preparation error1
Product dosage form issue1
Product dispensing issue1
Product design issue1
Product deposit1
Procedural haemorrhage1
Priapism1
Presyncope1
Pressure of speech1
Premature delivery1
Poor peripheral circulation1
Polydipsia1
Pneumothorax1
Pneumonia1
Placenta praevia1
PHARMACEUTICAL PRODUCT COMPLAINT1
pH body fluid decreased1
Personal relationship issue1
Peripheral arterial occlusive disease1
Perinatal HIV infection1
Pericardial haemorrhage1
Penile oedema1
Penile necrosis1
PARTNER STRESS1
Paraphilia1
Papilloma viral infection1
Panic reaction1
Panic disorder1
Pancytopenia1
Pancreatitis relapsing1
Painful respiration1
Oxygen saturation decreased1
Osteoarthritis1
Osmolar gap1
Orthostatic hypotension1
Orthopnoea1
Orchitis1
Oral mucosal discolouration1
Optic nerve disorder1
Onychophagia1
Nystagmus1
NEUTROPHIL PERCENTAGE INCREASED1
Neutropenia1
Neuropathic muscular atrophy1
Neuromuscular blockade1
Neuroleptic malignant syndrome1
Nerve compression1
Nephrolithiasis1
Negative thoughts1
Necrotising fasciitis1
Near death experience1
Nasal dryness1
Narcolepsy1
Narcissistic personality disorder1
Myxoedema coma1
Myofascial pain syndrome1
Myocarditis1
Myelopathy1
Mutism1
Musculoskeletal stiffness1
Musculoskeletal pain1
Musculoskeletal discomfort1
Muscle twitching1
Muscle tightness1
Muscle rigidity1
Multiple sclerosis relapse1
Motor dysfunction1
Mobility decreased1
Mitral valve prolapse1
Miosis1
Metabolic disorder1
Mental status changes1
Mental disability1
Menstruation irregular1
Menstrual disorder1
Menopausal symptoms1
Meningitis cryptococcal1
Mass1
Marchiafava-Bignami disease1
Major depression1
Lymphadenopathy1
Lupus-like syndrome1
Lower gastrointestinal haemorrhage1
Low density lipoprotein increased1
Loss of libido1
Loss of employment1
Liver injury1
Liver function test abnormal1
Liver disorder1
Liquid product physical issue1
Lip swelling1
Lacrimation increased1
Laceration1
Joint swelling1
Joint hyperextension1
Job dissatisfaction1
Jaw disorder1
JAUNDICE1
Ischaemic limb pain1
Ischaemic hepatitis1
Iron deficiency anaemia1
Investigation abnormal1
Intrusive thoughts1
Intracranial artery dissection1
Intracranial aneurysm1
Intracardiac thrombus1
Intervertebral disc protrusion1
Intervertebral disc degeneration1
Internal haemorrhage1
Intercepted product selection error1
Intercepted drug dispensing error1
Intentional underdose1
Intentional dose omission1
Insulin-like growth factor decreased1
Influenza like illness1
Influenza1
Infectious mononucleosis1
Infection parasitic1
Infection1
Incorrect route of product administration1
Incorrect route of drug administration1
Incorrect product storage1
Incorrect drug administration rate1
Incorrect disposal of product1
INCONTINENCE1
Impulse-control disorder1
Imperception1
Impatience1
Impaired healing1
Impaired gastric emptying1
Immune system disorder1
Hypoxic-ischaemic encephalopathy1
Hyponatraemia1
Hypokinesia1
Hypoaesthesia oral1
Hypervigilance1
Hypertrophy of tongue papillae1
Hypertensive crisis1
Hyperpyrexia1
Hyperproteinaemia1
Hyperkinesia1
Hyperacusis1
Hypercalcaemia1
Hunger1
Humerus fracture1
Hot flush1
Hostility1
Homeless1
Herpes virus infection1
Hearing disability1
Head injury1
Hangover1
Hallucinations, mixed1
Hallucination, tactile1
Hair texture abnormal1
Haemorrhage urinary tract1
Haemorrhage1
Haematochezia1
Gynaecomastia1
Gun shot wound1
GRAND MAL CONVULSION1
Glucose tolerance impaired1
General symptom1
Gastrooesophageal reflux disease1
Gastrointestinal tract irritation1
Gastroenteritis1
Gallbladder disorder1
Fungal infection1
Foreign body1
Food craving1
Flushing1
Fluid retention1
Flatulence1
Flat affect1
Fistula1
Feeling of relaxation1
Feeding disorder neonatal1
Fat tissue increased1
Family stress1
Facial pain1
FACIAL BONES FRACTURE1
Eye allergy1
Exsanguination1
Exposure to unspecified agent1
Exercise tolerance decreased1
Exercise electrocardiogram abnormal1
Excoriation1
Excessive ocular convergence1
Eosinophilia1
Environmental exposure1
Endometriosis1
Endocrine ophthalmopathy1
Encephalomalacia1
Encephalitis viral1
Embolism1
Electrocardiogram T wave inversion1
Electrocardiogram ST segment depression1
Ejection fraction decreased1
Ejaculation disorder1
Eating disorder1
Ear pain1
Ear disorder1
Dyspnoea exertional1
Dysphonia1
Dysaesthesia1
Duodenal perforation1
Dry skin1
Dry eye1
Drug tolerance decreased1
Drug screen negative1
Drug screen false positive1
Drug level increased1
Drug level below therapeutic1
Drug ineffective for unapproved indication1
Drug dose titration not performed1
Drug dispensed to wrong patient1
Drug administration error1
Drowning1
Drooling1
Disruptive mood dysregulation disorder1
Disorientation1
Disease recurrence1
Discharge1
Diplopia1
Diarrhoea haemorrhagic1
DIALYSIS1
Device issue1
Device dispensing error1
Dermatitis atopic1
Depressive symptom1
Demyelination1
Dementia1
Decreased interest1
Decreased eye contact1
Decreased activity1
Cyst1
CYP2D6 polymorphism1
Cyanosis1
Cushing's syndrome1
CROHN'S DISEASE1
Crime1
COVID-19 immunisation1
Congenital naevus1
Conduct disorder1
Concussion1
Compulsive cheek biting1
Compartment syndrome1
Coma scale abnormal1
Clavicle fracture1
Claustrophobia1
Circulatory collapse1
Chronic obstructive pulmonary disease1
Chronic fatigue syndrome1
Chorioretinopathy1
Chordae tendinae rupture1
Cholelithiasis1
Cerebral ischaemia1
Cerebral artery occlusion1
Cerebellar ataxia1
Central nervous system lesion1
Central nervous system infection1
Carotid artery dissection1
Cardioversion1
Calculus ureteric1
Calculus bladder1
C-reactive protein increased1
Burning sensation1
Burning mouth syndrome1
Bundle branch block right1
Bronchitis1
Breast atrophy1
Brain stem infarction1
Brain neoplasm1
Brain herniation1
Brain fog1
Bradycardia1
Body temperature increased1
Body mass index increased1
Body mass index abnormal1
Body height increased1
Body height decreased1
Blood urine present1
Blood testosterone increased1
Blood pressure normal1
Blood lactic acid increased1
Blood glucose increased1
Blood creatinine increased1
Blood creatine phosphokinase abnormal1
Blood cholesterol abnormal1
BLINDNESS1
Bladder irritation1
Bladder discomfort1
Bipolar II disorder1
Back injury1
Back disorder1
Auditory disorder1
Attention deficit hyperactivity disorder1
Atrioventricular block first degree1
Ataxia1
Asthma exercise induced1
Aspartate aminotransferase increased1
Aspartate aminotransferase abnormal1
Ascites1
Artificial menopause1
Arthropathy1
Arthritis1
Arteriospasm coronary1
Arrhythmia1
Apparent death1
Aphonia1
Aphasia1
Aortic valve replacement1
Aortic dilatation1
Anxiety disorder1
Antisocial behaviour1
Anosmia1
ANOREXIA1
Angioedema1
Anaphylactic reaction1
Anal incontinence1
Amenorrhoea1
Alcoholism1
ALCOHOL USE1
ALCOHOL POISONING1
Alcohol abuse1
Alanine aminotransferase increased1
Alanine aminotransferase abnormal1
Agraphia1
Adulterated product1
Adrenal atrophy1
Acute respiratory failure1
Acute respiratory distress syndrome1
Acute pulmonary oedema1
Acute psychosis1
Acute coronary syndrome1
Acne cystic1
Acidosis1
ACCIDENTAL EXPOSURE1
Accidental death1
Accident1
Abnormal weight gain1
Abdominal pain lower1





Toxicity information:

Toxicity class: 2
Toxicity type: cardiovascular
LD50: 21 mg/kg



External links:

ChEBML: CHEMBL405
DrugBank: DB00182