Aminoglutethimide
General information:
| Withdrawn ID: | w124 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | L02BG01 |
| Molecular Formula: | C13H16N2O2 |
| Molweight: | 232.278 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1960 |
| First withdrawn: | 1966 |
| Last withdrawn: | 1966 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/12378031 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Aminoglutethimide as primary suspect: | 3 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 2 |
|---|
Reported side-effects:
| Side-effect | Case number |
|---|---|
| SOMNOLENCE | 2 |
| PYREXIA | 2 |
| HEPATECTOMY | 1 |
| BILIARY TRACT DISORDER | 1 |
| BLOOD CORTISOL INCREASED | 1 |
| CHEST X-RAY ABNORMAL | 1 |
| COMPUTERISED TOMOGRAM ABNORMAL | 1 |
| CONFUSIONAL STATE | 1 |
| DYSARTHRIA | 1 |
| EOSINOPHILIA | 1 |
| EOSINOPHILIC PNEUMONIA ACUTE | 1 |
| WHITE BLOOD CELL COUNT INCREASED | 1 |
| PROCEDURAL SITE REACTION | 1 |
| PRURITUS | 1 |
| RASH | 1 |
| RED BLOOD CELL SEDIMENTATION RATE INCREASED | 1 |
| RESTRICTIVE PULMONARY DISEASE | 1 |
| URTICARIA | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P11511 | 5.2 | Aromatase | CP19A_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | multiple |
| LD50: | 630 mg/kg |
External links:
| ChEBML: | CHEMBL488 |
|---|---|
| DrugBank: | DB00357 |