Diethylstilbestrol
General information:
| Withdrawn ID: | w119 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | G03CB02 |
| L02AA01 | |
| Molecular Formula: | C18H20O2 |
| Molweight: | 268.356 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1973 |
| First withdrawn: | 1973 |
| Last withdrawn: | 1983 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/25935922 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P03372 | 0.007 | Estrogen receptor | ESR1_HUMAN |
| P23219 | 5600 | Prostaglandin G/H synthase 1 | PGH1_HUMAN |
| P24557 | 4359 | Thromboxane-A synthase | THAS_HUMAN |
| P28482 | 316.2 | Mitogen-activated protein kinase 1 | MK01_HUMAN |
| P62508 | 630 | Estrogen-related receptor gamma | ERR3_HUMAN |
| Q03164 | 10000 | Histone-lysine N-methyltransferase 2A | KMT2A_HUMAN |
| Q92731 | 0.63 | Estrogen receptor beta | ESR2_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | reproductive |
| LD50: | 2830 mg/kg |
External links:
| ChEBML: | CHEMBL411 |
|---|---|
| DrugBank: | DB00255 |