Clioquinol
General information:
| Withdrawn ID: | w109 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | D09AA10 |
| G01AC02 | |
| P01AA02 | |
| S02AA05 | |
| Molecular Formula: | C9H5ClINO |
| Molweight: | 305.5 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1970 |
| First withdrawn: | 1970 |
| Last withdrawn: | 1990 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/25758465 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O75604 | 1584.9 | Ubiquitin carboxyl-terminal hydrolase 2 | UBP2_HUMAN |
| P02545 | 100 | Prelamin-A/C | LMNA_HUMAN |
| P04637 | 5011.9 | Cellular tumor antigen p53 | P53_HUMAN |
| P05067 | 9800 | Amyloid-beta precursor protein | A4_HUMAN |
| P16050 | 1258.9 | Polyunsaturated fatty acid lipoxygenase ALOX15 | LOX15_HUMAN |
| P18054 | 707.9 | Polyunsaturated fatty acid lipoxygenase ALOX12 | LOX12_HUMAN |
| P41145 | 5790 | Kappa-type opioid receptor | OPRK_HUMAN |
| P42858 | 10000 | Huntingtin | HD_HUMAN |
| Q16637 | 5623.4 | Survival motor neuron protein | SMN_HUMAN |
| Q16665 | 39.8 | Hypoxia-inducible factor 1-alpha | HIF1A_HUMAN |
| Q9NUW8 | 631 | Tyrosyl-DNA phosphodiesterase 1 | TYDP1_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | neurological |
| LD50: | 3000 mg/kg |
External links:
| ChEBML: | CHEMBL497 |
|---|---|
| DrugBank: | DB04815 |