Encainide
General information:
| Withdrawn ID: | w106 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | C01BC08 |
| Molecular Formula: | C22H28N2O2 |
| Molweight: | 352.47 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1986 |
| First withdrawn: | 1991 |
| Last withdrawn: | 1991 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/8046314 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Encainide as primary suspect: | 35 |
|---|
Reported final outcomes:
| Death: | 32 |
|---|---|
| Hospitalization (initial or prolonged): | 5 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| DEATH | 21 |
| CEREBROVASCULAR ACCIDENT | 2 |
| ISCHAEMIC CARDIOMYOPATHY | 1 |
| CARDIAC ARREST | 1 |
| CHRONIC OBSTRUCTIVE AIRWAYS DISEASE | 1 |
| COLON CANCER METASTATIC | 1 |
| COLORECTAL CANCER | 1 |
| COMPLETED SUICIDE | 1 |
| CONGESTIVE CARDIOMYOPATHY | 1 |
| DIVERTICULITIS | 1 |
| ELECTROCARDIOGRAM QT PROLONGED | 1 |
| GANGRENE | 1 |
| VENTRICULAR TACHYCARDIA | 1 |
| LEUKAEMIA | 1 |
| LUNG CANCER METASTATIC | 1 |
| MULTI-ORGAN FAILURE | 1 |
| PNEUMONIA | 1 |
| PULMONARY FIBROSIS | 1 |
| RESPIRATORY FAILURE | 1 |
| RESTRICTIVE PULMONARY DISEASE | 1 |
| SEPSIS | 1 |
| SUPRAVENTRICULAR TACHYCARDIA | 1 |
| SYNCOPE | 1 |
Toxicity information:
| Toxicity class: | 3 |
|---|---|
| Toxicity type: | cardiovascular |
| LD50: | 57 mg/kg |
External links:
| ChEBML: | CHEMBL315838 |
|---|---|
| DrugBank: | DB01228 |