topotecan


EMA46



General information:


Withdrawn ID: EMA46
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): L01XX17
Molecular Formula: C23H23N3O5
Molweight: 421.446



Withdrawal information:


Withdrawn due to drug safety reasons:No



Side-effects:

Total reported cases (submitted by medical professionals) with topotecan as primary suspect: 1738


Reported final outcomes:
Hospitalization (initial or prolonged): 865
Death: 447
Life-Threatening condition: 100
Disability: 53
Intervention required to prevent permanent impairment/damage: 9
Congenital anomaly: 2


Reported side-effects:

Side-effect Case number
ANAEMIA283
Nausea175
WHITE BLOOD CELL COUNT DECREASED171
PLATELET COUNT DECREASED156
THROMBOCYTOPENIA154
PYREXIA153
DISEASE PROGRESSION140
Neutrophil count decreased133
VOMITING132
NEUTROPENIA132
FEBRILE NEUTROPENIA130
FATIGUE119
DYSPNOEA118
DEATH102
DIARRHOEA98
Red blood cell count decreased84
PANCYTOPENIA84
MALIGNANT NEOPLASM PROGRESSION81
DECREASED APPETITE79
HAEMOGLOBIN DECREASED75
DEHYDRATION75
GENERAL PHYSICAL HEALTH DETERIORATION70
LEUKOPENIA67
PNEUMONIA66
ASTHENIA64
Product use in unapproved indication63
ABDOMINAL PAIN55
CONFUSIONAL STATE49
SEPSIS43
HYPOTENSION41
RESPIRATORY FAILURE39
Off label use39
FEBRILE BONE MARROW APLASIA38
DIZZINESS37
CONDITION AGGRAVATED36
HYPONATRAEMIA35
COUGH34
CONSTIPATION34
HEADACHE33
INTERSTITIAL LUNG DISEASE31
RENAL FAILURE30
PULMONARY EMBOLISM29
PLEURAL EFFUSION29
BLOOD CREATININE INCREASED29
ASCITES29
BONE MARROW FAILURE28
PAIN27
WEIGHT DECREASED26
NEOPLASM PROGRESSION26
ILEUS26
ALANINE AMINOTRANSFERASE INCREASED26
MALAISE25
BLOOD LACTATE DEHYDROGENASE INCREASED25
ASPARTATE AMINOTRANSFERASE INCREASED25
TACHYCARDIA24
HAEMATOTOXICITY24
EPISTAXIS24
CHEST PAIN24
C-REACTIVE PROTEIN INCREASED24
LYMPHOPENIA23
ANOREXIA23
Product use issue22
HYPOKALAEMIA22
SEPTIC SHOCK21
OEDEMA PERIPHERAL21
FALL21
URINARY TRACT INFECTION20
TOXICITY TO VARIOUS AGENTS20
RASH20
DRUG INEFFECTIVE20
BLOOD UREA INCREASED20
HAEMATURIA19
MUCOSAL INFLAMMATION18
METASTASES TO CENTRAL NERVOUS SYSTEM18
ABDOMINAL PAIN UPPER18
Abdominal distension18
VITREOUS HAEMORRHAGE17
SMALL CELL LUNG CANCER STAGE UNSPECIFIED17
PROTEIN TOTAL DECREASED17
HYPERTENSION17
BLOOD SODIUM DECREASED17
Alopecia17
RENAL FAILURE ACUTE16
CHILLS16
BACK PAIN16
LETHARGY15
HYPOXIA15
DRUG TOXICITY15
DEPRESSED LEVEL OF CONSCIOUSNESS15
BLOOD ALKALINE PHOSPHATASE INCREASED15
MENTAL STATUS CHANGES14
Iris atrophy14
Chorioretinal atrophy14
SYNCOPE13
SOMNOLENCE13
LUNG NEOPLASM MALIGNANT13
INFECTION13
HEPATIC FAILURE13
COLITIS13
BLOOD BILIRUBIN INCREASED13
PRURITUS12
LYMPHOCYTE COUNT DECREASED12
HYDRONEPHROSIS12
HAEMORRHAGE12
HAEMATOCRIT DECREASED12
DISORIENTATION12
DEEP VEIN THROMBOSIS12
SUBILEUS11
PNEUMONITIS11
NEUTROPENIC SEPSIS11
NEUROPATHY PERIPHERAL11
MUSCULAR WEAKNESS11
Genotoxicity11
CARDIAC ARREST11
BLOOD POTASSIUM DECREASED11
ACUTE RESPIRATORY DISTRESS SYNDROME11
RESPIRATORY DISTRESS10
PAIN IN EXTREMITY10
MULTI-ORGAN FAILURE10
HYPERSENSITIVITY10
GASTROINTESTINAL HAEMORRHAGE10
CONVULSION10
CIRCULATORY COLLAPSE10
Choroidal dystrophy10
Cerebral cyst10
BLOOD CHLORIDE DECREASED10
BLOOD ALBUMIN DECREASED10
Acute febrile neutrophilic dermatosis10
VAGINAL HAEMORRHAGE9
TREATMENT FAILURE9
PARAESTHESIA9
OEDEMA9
METASTASES TO BONE9
INTESTINAL PERFORATION9
HYPOCALCAEMIA9
HERPES ZOSTER9
HEPATOTOXICITY9
HEPATIC FUNCTION ABNORMAL9
HAEMATEMESIS9
GAIT DISTURBANCE9
ERYTHEMA9
Drug resistance9
Diplopia9
Acute kidney injury9
WHITE BLOOD CELL COUNT INCREASED8
VERTIGO8
TREMOR8
Therapeutic response decreased8
STOMATITIS8
POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME8
PLATELET COUNT INCREASED8
PALLOR8
LOSS OF CONSCIOUSNESS8
HYPOPROTEINAEMIA8
HYPOALBUMINAEMIA8
HEART RATE INCREASED8
EATING DISORDER8
Drug interaction8
CHOLESTASIS8
CARDIAC FAILURE8
BODY TEMPERATURE INCREASED8
BLOOD POTASSIUM INCREASED8
ATRIAL FIBRILLATION8
TACHYPNOEA7
SINUS TACHYCARDIA7
Retinopathy7
PYELONEPHRITIS7
PULMONARY HAEMORRHAGE7
PRODUCTIVE COUGH7
OXYGEN SATURATION DECREASED7
OCULAR TOXICITY7
LUNG DISORDER7
LARGE INTESTINE PERFORATION7
Iris adhesions7
ILL-DEFINED DISORDER7
HYPERKALAEMIA7
Heterochromia iridis7
HEPATIC ENZYME INCREASED7
FLUSHING7
FEELING ABNORMAL7
Enophthalmos7
DYSGEUSIA7
COGNITIVE DISORDER7
CELLULITIS7
BONE MARROW DEPRESSION7
BLOOD CULTURE POSITIVE7
ACUTE MYELOID LEUKAEMIA7
VISUAL ACUITY REDUCED6
VISION BLURRED6
Transfusion6
SMALL INTESTINAL OBSTRUCTION6
Small cell lung cancer6
SKIN LESION6
Seizure6
Scleritis6
Pulmonary toxicity6
PROTEIN URINE PRESENT6
MYOCARDIAL INFARCTION6
Multiple organ dysfunction syndrome6
METASTASES TO LIVER6
LIVER DISORDER6
INTESTINAL OBSTRUCTION6
HYPOTONIA6
HYPOMAGNESAEMIA6
HYPERGLYCAEMIA6
HYPERBILIRUBINAEMIA6
GASTROINTESTINAL PERFORATION6
GAMMA-GLUTAMYLTRANSFERASE INCREASED6
FAECALOMA6
EYELID OEDEMA6
ENCEPHALITIS6
Disease recurrence6
DIARRHOEA HAEMORRHAGIC6
DEVICE RELATED INFECTION6
Cyst6
CONJUNCTIVAL HYPERAEMIA6
Conjunctival haemorrhage6
Clostridium colitis6
CHRONIC OBSTRUCTIVE PULMONARY DISEASE6
CEREBROVASCULAR ACCIDENT6
BLOOD CALCIUM DECREASED6
Atelectasis6
APHASIA6
ANAPHYLACTIC REACTION6
AMNESIA6
AGRANULOCYTOSIS6
VENOOCCLUSIVE DISEASE5
URINARY RETENTION5
THROMBOSIS5
SUDDEN DEATH5
STAPHYLOCOCCAL INFECTION5
Rhinovirus infection5
Retinal detachment5
RENAL IMPAIRMENT5
PNEUMOTHORAX5
Platelet transfusion5
PETECHIAE5
PERITONITIS5
PERFORMANCE STATUS DECREASED5
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME5
Neuroblastoma recurrent5
MONOCYTE COUNT DECREASED5
METABOLIC ACIDOSIS5
LYMPHOCYTE COUNT INCREASED5
LYMPHADENOPATHY5
LUNG INFILTRATION5
Lenticular opacities5
INSOMNIA5
INFLAMMATION5
HYPOPHAGIA5
HEMIPARESIS5
FUNGAL INFECTION5
FULL BLOOD COUNT DECREASED5
FLANK PAIN5
FAILURE TO THRIVE5
EMBOLISM5
DYSPNOEA EXACERBATED5
DYSPHAGIA5
Dry eye5
DISCOMFORT5
Dermatitis5
Conjunctivitis5
Cataract subcapsular5
CARDIO-RESPIRATORY ARREST5
CARDIAC FAILURE CONGESTIVE5
BRONCHITIS5
Brain stem glioma5
BLOOD PRESSURE DECREASED5
BLOOD GLUCOSE INCREASED5
BLOOD ELECTROLYTES ABNORMAL5
BACTERIAL INFECTION5
ARTHRALGIA5
ADVERSE DRUG REACTION5
ACCIDENTAL OVERDOSE5
WHEEZING4
VISUAL IMPAIRMENT4
VENTRICULAR TACHYCARDIA4
Venous thrombosis4
VENOOCCLUSIVE LIVER DISEASE4
URTICARIA4
UPPER RESPIRATORY TRACT INFECTION4
THROMBOCYTOSIS4
THROMBOCYTHAEMIA4
THERAPY NON-RESPONDER4
STEM CELL TRANSPLANT4
SHOCK HAEMORRHAGIC4
SHOCK4
RESPIRATORY ARREST4
RECTAL HAEMORRHAGE4
RASH VESICULAR4
Rash papular4
RADIATION PNEUMONITIS4
Post transplant lymphoproliferative disorder4
PNEUMONIA ASPIRATION4
PHOTOPSIA4
Peripheral swelling4
PERIPHERAL SENSORY NEUROPATHY4
Papule4
OVARIAN CANCER4
ORTHOSTATIC HYPOTENSION4
Oropharyngeal pain4
NEUTROPHIL COUNT ABNORMAL4
NERVOUS SYSTEM DISORDER4
Nephroblastoma4
NEOPLASM RECURRENCE4
Musculoskeletal pain4
METASTATIC NEOPLASM4
METASTASES TO MENINGES4
LUNG INFECTION4
LIPASE INCREASED4
Lactic acidosis4
INFUSION RELATED REACTION4
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION4
ILEUS PARALYTIC4
HYDROCEPHALUS4
Hospitalisation4
Hospice care4
HERPES SIMPLEX4
HAEMOPTYSIS4
GLUCOSE URINE PRESENT4
GASTRITIS4
FACIAL PALSY4
Eye irritation4
EOSINOPHIL COUNT DECREASED4
ENCEPHALOPATHY4
DYSURIA4
DYSPNOEA EXERTIONAL4
DRUG HYPERSENSITIVITY4
DELIRIUM4
CONJUNCTIVAL OEDEMA4
CHEST DISCOMFORT4
CEREBELLAR SYNDROME4
CARDIAC DISORDER4
BREATH SOUNDS ABNORMAL4
BLISTER4
Autonomic neuropathy4
ATRIAL FLUTTER4
ANXIETY4
Alveolar soft part sarcoma4
ACUTE RESPIRATORY FAILURE4
ABDOMINAL PAIN LOWER4
WHITE BLOOD CELLS URINE POSITIVE3
WHITE BLOOD CELL COUNT ABNORMAL3
VIth nerve paralysis3
VENOUS THROMBOSIS LIMB3
VENA CAVA THROMBOSIS3
URINE OUTPUT DECREASED3
TRANSIENT ISCHAEMIC ATTACK3
Transaminases increased3
Systemic infection3
Staphylococcal sepsis3
SKIN ULCER3
Second primary malignancy3
SCOTOMA3
RHINORRHOEA3
Retinal ischaemia3
RETINAL HAEMORRHAGE3
RESPIRATORY TRACT INFECTION3
RENAL DISORDER3
Rash pustular3
RASH MACULAR3
RASH ERYTHEMATOUS3
PURPURA3
PULMONARY OEDEMA3
PULMONARY MASS3
PULMONARY FIBROSIS3
Proteus test positive3
Proteinuria3
POLYNEUROPATHY3
PHARYNGOLARYNGEAL PAIN3
PERIPHERAL COLDNESS3
Periorbital oedema3
Parainfluenzae virus infection3
PANCREATITIS3
PALPITATIONS3
PAINFUL RESPIRATION3
OVERDOSE3
Ovarian cancer recurrent3
OVARIAN CANCER METASTATIC3
ORAL FUNGAL INFECTION3
OPTIC NEURITIS3
Optic ischaemic neuropathy3
Ocular vascular disorder3
OCULAR HYPERAEMIA3
NEUTROPHIL COUNT INCREASED3
NEUROTOXICITY3
Neuroblastoma3
Myelodysplastic syndrome3
MUSCLE SPASMS3
MONOCYTE COUNT INCREASED3
METASTASES TO PLEURA3
METASTASES TO PERITONEUM3
Metastases to lymph nodes3
Metapneumovirus infection3
MEDICATION ERROR3
MALIGNANT ASCITES3
LUNG CANCER METASTATIC3
Leukocoria3
Lacrimation increased3
ISCHAEMIC STROKE3
ISCHAEMIA3
Injection site reaction3
IMPAIRED GASTRIC EMPTYING3
HYPOVOLAEMIA3
HYPOGLYCAEMIA3
HYPERTHERMIA3
HYPERHIDROSIS3
Hyperamylasaemia3
HYPERAMMONAEMIA3
HEART RATE DECREASED3
HALLUCINATION, VISUAL3
Haemodialysis3
Genital haemorrhage3
FLATULENCE3
FISTULA3
FEMALE GENITAL TRACT FISTULA3
ESCHERICHIA URINARY TRACT INFECTION3
ESCHERICHIA INFECTION3
Erythema multiforme3
ENTEROVESICAL FISTULA3
Drug effect incomplete3
DIZZINESS POSTURAL3
DISTURBANCE IN ATTENTION3
DISSEMINATED INTRAVASCULAR COAGULATION3
DIFFERENTIAL WHITE BLOOD CELL COUNT ABNORMAL3
Desmoplastic small round cell tumour3
DEPRESSION3
Deafness neurosensory3
Cytopenia3
Cystitis haemorrhagic3
Cystitis escherichia3
CYANOSIS3
CONTUSION3
COMA3
CLOSTRIDIAL INFECTION3
Chorioretinal disorder3
CEREBRAL INFARCTION3
CEREBRAL HAEMORRHAGE3
CEREBRAL DISORDER3
CARDIOVASCULAR DISORDER3
Cardiac dysfunction3
CARBOHYDRATE ANTIGEN 125 INCREASED3
Candida infection3
CANCER PAIN3
CACHEXIA3
BRAIN OEDEMA3
BONE MARROW DISORDER3
BLOOD PHOSPHORUS INCREASED3
BLOOD MAGNESIUM DECREASED3
Blood lactic acid increased3
BLOOD CREATINE INCREASED3
BLOOD COUNT ABNORMAL3
Bladder obstruction3
BASOPHIL COUNT DECREASED3
BALANCE DISORDER3
Arteriosclerotic retinopathy3
ANGINA PECTORIS3
ANAPHYLACTIC SHOCK3
AGITATION3
Acute interstitial pneumonitis3
ABDOMINAL DISCOMFORT3
WOUND2
WHITE BLOOD CELL DISORDER2
VITREOUS FLOATERS2
VIRAL INFECTION2
VESTIBULAR DISORDER2
VASCULITIS2
UROBILIN URINE PRESENT2
URINE ODOUR ABNORMAL2
URINARY TRACT DISORDER2
UPPER GASTROINTESTINAL HAEMORRHAGE2
Unresponsive to stimuli2
UNEVALUABLE EVENT2
TUMOUR MARKER INCREASED2
TOXIC SKIN ERUPTION2
Thrombotic microangiopathy2
Therapy cessation2
Therapeutic response changed2
TACHYARRHYTHMIA2
SYSTEMIC CANDIDA2
Swelling of eyelid2
Supraventricular tachycardia2
Subretinal fibrosis2
STATUS EPILEPTICUS2
Spinal cord infection2
SMALL CELL LUNG CANCER METASTATIC2
Sleep apnoea syndrome2
SENSORY DISTURBANCE2
SCAB2
SARCOMA2
Rhonchi2
RHINITIS2
RESPIRATORY ALKALOSIS2
Renal tubular disorder2
Recall phenomenon2
RASH PRURITIC2
RASH MACULO-PAPULAR2
PULMONARY THROMBOSIS2
Pulmonary hypertension2
Pulmonary hilum mass2
PSYCHOTIC DISORDER2
Product storage error2
Proctalgia2
POST PROCEDURAL VOMITING2
POST PROCEDURAL NAUSEA2
POLYURIA2
PO2 DECREASED2
Pneumonia fungal2
PLATELET COUNT2
Pinealoblastoma2
PHARYNGITIS2
Pharyngeal oedema2
PERITONEAL NEOPLASM2
Peritoneal haemorrhage2
Periorbital swelling2
PERICARDIAL EFFUSION2
PELVIC PAIN2
PARANEOPLASTIC SYNDROME2
PANCREATITIS ACUTE2
Packed red blood cell transfusion2
Ovarian neoplasm2
Orthopnoea2
Orbital oedema2
Oral pain2
ORAL CANDIDIASIS2
Optic atrophy2
Oligodipsia2
OESOPHAGITIS2
NEUROLOGICAL SYMPTOM2
NEURALGIA2
NEPHROPATHY TOXIC2
NEOPLASM MALIGNANT2
Necrotising retinitis2
Necrosis2
MYOCARDIAL ISCHAEMIA2
Myalgia2
MUSCLE TWITCHING2
MOVEMENT DISORDER2
Mouth ulceration2
MOTOR DYSFUNCTION2
Metastases to spine2
METASTASES TO ABDOMINAL CAVITY2
MENTAL DISORDER DUE TO A GENERAL MEDICAL CONDITION2
MENINGITIS2
MALNUTRITION2
MALIGNANT PLEURAL EFFUSION2
Laryngeal oedema2
JAUNDICE2
Iridocyclitis2
INTRACARDIAC THROMBUS2
Intestinal ischaemia2
INTERNATIONAL NORMALISED RATIO INCREASED2
INCREASED UPPER AIRWAY SECRETION2
INCORRECT PRODUCT STORAGE2
HYPOCHLORAEMIA2
Hypoaesthesia2
HYPOACUSIS2
HYPERTENSIVE CRISIS2
HYPERPYREXIA2
HYPERCALCAEMIA2
HOT FLUSH2
HICCUPS2
HEPATITIS TOXIC2
HEMIPLEGIA2
Haemorrhoids2
HAEMOLYTIC URAEMIC SYNDROME2
HAEMOGLOBIN ABNORMAL2
Haematochezia2
GRANULOCYTE COUNT DECREASED2
GRAND MAL CONVULSION2
Generalised tonic-clonic seizure2
GASTROINTESTINAL MOTILITY DISORDER2
GASTROENTERITIS2
GASTRIC HAEMORRHAGE2
GASTRIC DISORDER2
FEELING HOT2
EYE SWELLING2
EYE EXCISION2
EXFOLIATIVE RASH2
EPILEPSY2
Enterovirus infection2
ENTEROCUTANEOUS FISTULA2
ELECTROLYTE IMBALANCE2
ELECTROCARDIOGRAM T WAVE INVERSION2
EJECTION FRACTION DECREASED2
Eastern Cooperative Oncology Group performance status worsened2
DYSPHONIA2
DYSPEPSIA2
DYSARTHRIA2
Drug effect decreased2
Drug dose omission2
DRUG ADMINISTRATION ERROR2
Drug administered to patient of inappropriate age2
DERMATITIS BULLOUS2
DEAFNESS2
CYSTITIS2
CSF GLUCOSE INCREASED2
COMA SCALE ABNORMAL2
Colloid brain cyst2
Clostridium difficile colitis2
Choroidal infarction2
Chondrocalcinosis pyrophosphate2
CHOLECYSTITIS2
Chloroma2
CHEST X-RAY ABNORMAL2
Cerebral mass effect2
Catheter site infection2
CARDIOTOXICITY2
CARDIOPULMONARY FAILURE2
BURNING SENSATION2
BRONCHIAL OBSTRUCTION2
BRAIN CANCER METASTATIC2
BLOOD URINE PRESENT2
BLOOD TEST ABNORMAL2
BLOOD PRESSURE INCREASED2
BLOOD CREATININE ABNORMAL2
BLOOD AMYLASE INCREASED2
BLINDNESS2
BACTERIAL TEST POSITIVE2
Bacteraemia2
Atrioventricular block second degree2
ASPIRATION2
ASPERGILLOSIS2
Arterial thrombosis2
AREFLEXIA2
Appendicitis2
APLASIA2
Aortitis2
AMAUROSIS2
ALTERED STATE OF CONSCIOUSNESS2
ACUTE PULMONARY OEDEMA2
ACUTE MYOCARDIAL INFARCTION2
ACUTE CORONARY SYNDROME2
Acidosis2
Abdominal adhesions2
Wrong technique in product usage process1
Wrong schedule1
Wound infection staphylococcal1
White matter lesion1
White blood cell count1
Wheelchair user1
Weight increased1
Vulvovaginal pruritus1
VULVOVAGINAL PAIN1
Vitreous disorder1
VITREOUS DETACHMENT1
VISUAL DISTURBANCE1
VIIth nerve paralysis1
VERTIGO POSITIONAL1
VENTRICULAR EXTRASYSTOLES1
Vasogenic cerebral oedema1
VASCULITIS NECROTISING1
VASCULAR NEOPLASM1
Varicella zoster virus infection1
Vaginal inflammation1
VAGINAL DISCHARGE1
UROSEPSIS1
URINARY TRACT INFECTION ENTEROCOCCAL1
URINARY SEDIMENT PRESENT1
Urinary incontinence1
Urinary bladder sarcoma1
URINARY BLADDER HAEMORRHAGE1
URETHRITIS1
URETERIC OBSTRUCTION1
Type IV hypersensitivity reaction1
TYPE 2 DIABETES MELLITUS1
TUMOUR NECROSIS1
TUMOUR LYSIS SYNDROME1
Tumour invasion1
TUMOUR HAEMORRHAGE1
TUBERCULOSIS1
Troponin increased1
TRICHOSPORON INFECTION1
TREATMENT NONCOMPLIANCE1
Traumatic lung injury1
TRANSFUSION REACTION1
Transcription medication error1
Tracheobronchitis1
Toxic optic neuropathy1
TOOTHACHE1
TONSILLITIS1
Tongue necrosis1
Tongue coated1
TONGUE BITING1
Tinnitus1
Thymus enlargement1
Thrombocytopenic purpura1
Thirst1
Therapy interrupted1
Therapy change1
Therapeutic response unexpected1
Therapeutic product ineffective1
TETANY1
Terminal state1
Tenderness1
Taste disorder1
T-cell lymphoma1
Systemic mycosis1
SYSTEMIC LUPUS ERYTHEMATOSUS1
Swollen tongue1
Suprapubic pain1
Superior vena cava syndrome1
Sudden cardiac death1
SUBDURAL HAEMATOMA1
Subclavian artery thrombosis1
Subclavian artery embolism1
STUPOR1
Stridor1
STREPTOCOCCAL INFECTION1
STREPTOCOCCAL BACTERAEMIA1
Stoma site reaction1
STENT OCCLUSION1
Staphylococcus test positive1
STAPHYLOCOCCAL BACTERAEMIA1
Squamous cell carcinoma of skin1
SPUTUM PURULENT1
SPUTUM DISCOLOURED1
SPLENIC HAEMORRHAGE1
Spinal pain1
Spinal compression fracture1
SPIDER NAEVUS1
SPEECH DISORDER1
Small cell lung cancer recurrent1
Small cell carcinoma1
SLEEP DISORDER1
Skin toxicity1
Skin reaction1
SKIN OEDEMA1
Skin necrosis1
Skin mass1
SKIN EXFOLIATION1
Skin erosion1
Skin disorder1
Skin candida1
SINUSITIS1
SINUS RHYTHM1
SINUS HEADACHE1
SINUS CONGESTION1
SINUS ARRHYTHMIA1
SENSORY LOSS1
Selective eating disorder1
Sarcoma metastatic1
RIGHT VENTRICULAR FAILURE1
Right ventricular dilatation1
Rhabdomyosarcoma recurrent1
Rhabdomyolysis1
REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME1
RETROPERITONEAL HAEMATOMA1
RETROGRADE AMNESIA1
Retinal vein thrombosis1
Retinal vein occlusion1
Retinal toxicity1
Retinal artery thrombosis1
Retinal artery occlusion1
RETICULOCYTE COUNT DECREASED1
RESUSCITATION1
RESTLESSNESS1
Respiratory tract infection viral1
RESPIRATORY TRACT HAEMORRHAGE1
RESPIRATORY DISORDER1
RESPIRATORY DEPTH DECREASED1
Respiration abnormal1
Renal tubular injury1
RENAL SALT-WASTING SYNDROME1
RENAL PAIN1
RENAL INFARCT1
Renal colic1
Refractory anaemia with an excess of blasts1
Red cell distribution width decreased1
RED BLOOD CELLS URINE POSITIVE1
Recurrent cancer1
RECTAL ULCER1
Rectal perforation1
Rectal cancer stage IV1
Recalled product administered1
Rash maculovesicular1
RASH GENERALISED1
Rales1
RADIATION OESOPHAGITIS1
RADIATION INJURY1
PURULENT DISCHARGE1
Pulmonary haematoma1
Pulmonary congestion1
Psychomotor retardation1
PSEUDOPHAKIA1
PSEUDOMONAL BACTERAEMIA1
Prurigo1
PROTHROMBIN TIME PROLONGED1
PROTEIN TOTAL INCREASED1
PRODUCT QUALITY ISSUE1
Product dose omission issue1
Product dispensing error1
Product availability issue1
PROCTITIS1
PROCEDURAL COMPLICATION1
PRE-EXISTING DISEASE1
Potentiating drug interaction1
POSTOPERATIVE WOUND INFECTION1
POST PROCEDURAL HAEMORRHAGE1
Poor quality product administered1
Polydipsia1
POLLAKIURIA1
PNEUMOTHORAX TRAUMATIC1
Pneumoperitoneum1
PNEUMONIA VIRAL1
PNEUMONIA PRIMARY ATYPICAL1
Pneumonia legionella1
PNEUMONIA KLEBSIELLA1
PNEUMONIA CYTOMEGALOVIRAL1
Pneumocystis jirovecii pneumonia1
PNEUMOCYSTIS JIROVECI PNEUMONIA1
PNEUMOCYSTIS CARINII PNEUMONIA1
PNEUMOCOCCAL INFECTION1
Pleural mesothelioma malignant1
Pleural mass1
PLATELET DISORDER1
PLATELET COUNT ABNORMAL1
PHOTOPHOBIA1
PHLEBOTHROMBOSIS1
Peripheral artery occlusion1
PERICARDITIS1
PELVIC MASS1
PARESIS1
PARANASAL SINUS HYPERSECRETION1
Paradoxical drug reaction1
Pancreatic neuroendocrine tumour metastatic1
Pancreatic neuroendocrine tumour1
Pain of skin1
Ovarian epithelial cancer recurrent1
Ovarian epithelial cancer1
Ovarian cancer stage IV1
Otitis media acute1
Organising pneumonia1
ORAL INTAKE REDUCED1
Oral discomfort1
OPTIC NEUROPATHY1
Optic disc disorder1
Ophthalmic herpes zoster1
Oliguria1
Oesophageal infection1
OESOPHAGEAL CANCER METASTATIC1
Ocular neoplasm1
OBSTRUCTIVE UROPATHY1
Obstructive airways disorder1
NUTRITIONAL CONDITION ABNORMAL1
Normochromic normocytic anaemia1
Non-renal cell carcinoma of kidney1
Non-cardiac chest pain1
Nodule1
NO THERAPEUTIC RESPONSE1
NO ADVERSE EVENT1
Night sweats1
Neutrophilic dermatosis1
NEUTROPHIL TOXIC GRANULATION PRESENT1
NEUTROPHIL COUNT1
NEUTROPENIC INFECTION1
Neutropenic colitis1
Neurosis1
NEUROPATHY1
Neuroendocrine tumour1
NEUROENDOCRINE CARCINOMA OF THE SKIN1
Neuroendocrine carcinoma1
NEPHROPATHY1
Neoplasm1
Nasopharyngitis1
NAIL DISORDER1
Myocardial necrosis marker increased1
Myelodysplastic syndrome transformation1
Myelitis transverse1
MUSCULOSKELETAL CHEST PAIN1
Muscle spasticity1
MUSCLE CRAMP1
MUSCLE CONTRACTIONS INVOLUNTARY1
MUCOSAL ULCERATION1
Mouth haemorrhage1
MONOPLEGIA1
MOBILITY DECREASED1
MOANING1
MIXED LIVER INJURY1
Mixed deafness1
MICROLITHIASIS1
MICROANGIOPATHY1
METASTATIC UTERINE CANCER1
METASTASIS1
Metastases to vagina1
Metastases to thyroid1
Metastases to the mediastinum1
METASTASES TO SPLEEN1
Metastases to pituitary gland1
METASTASES TO PERINEUM1
Metastases to pancreas1
Metastases to lung1
MENINGEAL NEOPLASM1
MEMORY IMPAIRMENT1
Melaena1
Medulloblastoma1
Mechanical ileus1
Mean cell haemoglobin decreased1
Mass1
MARKEDLY REDUCED DIETARY INTAKE1
Macule1
Macular scar1
LYMPHOMA1
LYMPHOEDEMA1
LYMPHOCYTOSIS1
LYMPHOCYTE PERCENTAGE DECREASED1
LYMPHANGIOSIS CARCINOMATOSA1
Lymph node palpable1
LYMPH NODE PAIN1
LUNG NEOPLASM1
Lung adenocarcinoma1
LUMBAR SPINAL STENOSIS1
LOW DENSITY LIPOPROTEIN INCREASED1
LOCALISED OEDEMA1
Lobar pneumonia1
Liver function test increased1
LIVER FUNCTION TEST ABNORMAL1
LIPIDS INCREASED1
Lip haemorrhage1
LEUKOENCEPHALOPATHY1
LEUKOCYTOSIS1
Leukaemia1
LEFT VENTRICULAR HYPERTROPHY1
Left ventricular dysfunction1
LARGE INTESTINE CARCINOMA1
Large cell lung cancer1
LAPAROTOMY1
LABILE BLOOD PRESSURE1
KLEBSIELLA INFECTION1
Kidney infection1
Karnofsky scale worsened1
Kaposi's sarcoma1
JOINT SWELLING1
Jejunal perforation1
Jaundice cholestatic1
IRON DEFICIENCY1
Investigation1
Intracranial tumour haemorrhage1
Intestinal ulcer1
INTESTINAL FISTULA1
Intertrigo1
INTERCEPTED MEDICATION ERROR1
INJECTION SITE PAIN1
INJECTION SITE INDURATION1
Injection site erythema1
INFREQUENT BOWEL MOVEMENTS1
Influenza like illness1
Influenza A virus test positive1
Infarction1
INCORRECT DOSE ADMINISTERED1
Incontinence1
INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION1
Impetigo1
IMPAIRED SELF-CARE1
Immunodeficiency1
Illness1
Ileal perforation1
HYPOTHERMIA1
Hyporesponsive to stimuli1
HYPOPHOSPHATAEMIA1
Hypogeusia1
Hypertriglyceridaemia1
Hypersomnia1
Hypersensitivity vasculitis1
Hyperleukocytosis1
Hunger1
Hilar lymphadenopathy1
HIGH DENSITY LIPOPROTEIN INCREASED1
HIGH DENSITY LIPOPROTEIN DECREASED1
Hiatus hernia1
Herpes virus infection1
Hepatosplenomegaly1
HEPATOCELLULAR INJURY1
HEPATOCELLULAR DAMAGE1
HEPATITIS1
Hepatic necrosis1
Hepatic mass1
HEPATIC LESION1
HEPATIC CYST1
HEPATIC CANCER METASTATIC1
HEAD INJURY1
HAEMORRHAGIC STROKE1
HAEMORRHAGIC ANAEMIA1
HAEMORRHAGE URINARY TRACT1
Haemorrhage subcutaneous1
Haemoglobinaemia1
HAEMOGLOBIN1
Haemodynamic instability1
HAEMATOMA1
Haematological malignancy1
GROIN PAIN1
GRANULOCYTOPENIA1
GRANULOCYTES ABNORMAL1
GLYCOPEPTIDE ANTIBIOTIC RESISTANT ENTEROCOCCAL INFECTION1
Glossitis1
GERSTMANN'S SYNDROME1
GENITAL BURNING SENSATION1
GENERALISED OEDEMA1
GENERAL SYMPTOM1
Gene mutation1
GASTROOESOPHAGEAL REFLUX DISEASE1
GASTROINTESTINAL TOXICITY1
GASTROINTESTINAL SOUNDS ABNORMAL1
GASTROINTESTINAL FUNGAL INFECTION1
GASTROINTESTINAL DISORDER1
GASTROINTESTINAL CARCINOMA1
GASTROENTERITIS VIRAL1
Gastritis haemorrhagic1
GASTRIC ULCER HAEMORRHAGE1
GASTRIC ULCER1
GANGRENE1
Ganglioglioma1
GAMMA-GLUTAMYLTRANSFERASE ABNORMAL1
GALLBLADDER PERFORATION1
Gait inability1
FUNGAL OESOPHAGITIS1
FREQUENT BOWEL MOVEMENTS1
FOOD INTOLERANCE1
FLUID RETENTION1
FLUID OVERLOAD1
FIBULA FRACTURE1
Fibrin D dimer increased1
FEELING HOT AND COLD1
Feeding disorder1
FEBRILE INFECTION1
Faeces discoloured1
FAECALURIA1
FAECAL INCONTINENCE1
Facial pain1
FACE OEDEMA1
Eyelid rash1
EYELID FUNCTION DISORDER1
EYE PAIN1
Exposure to radiation1
EXPIRED DRUG ADMINISTERED1
EXANTHEM1
ESCHERICHIA SEPSIS1
Erythema of eyelid1
ERYSIPELAS1
Epstein-Barr virus associated lymphoproliferative disorder1
Epiglottic oedema1
EOSINOPHIL COUNT INCREASED1
ENTEROCOLITIS VIRAL1
ENTEROCOLITIS INFECTIOUS1
ENTEROCOLITIS1
ENTEROCOCCAL INFECTION1
ENTEROCOCCAL BACTERAEMIA1
ENTEROBACTER INFECTION1
ENTERITIS1
ENDOPHTHALMITIS1
Endocrine disorder1
EMPYEMA1
Emotional distress1
Embolism arterial1
ELECTROMECHANICAL DISSOCIATION1
ELECTROENCEPHALOGRAM ABNORMAL1
ELECTROCARDIOGRAM ST SEGMENT ELEVATION1
Eczema1
Ear pain1
EAR DISCOMFORT1
DYSTONIA1
DYSSTASIA1
DYSPHASIA1
DYSAESTHESIA1
DUODENITIS1
Duodenal obstruction1
Dry mouth1
Drug intolerance1
DRUG ERUPTION1
Drug effective for unapproved indication1
DROP ATTACKS1
Dizziness exertional1
DIVERTICULUM1
DIVERTICULITIS1
DISEASE COMPLICATION1
DIPLEGIA1
DILATATION ATRIAL1
DIFFICULTY IN WALKING1
Diaphragmatic disorder1
Diaphragm muscle weakness1
DIABETIC KETOACIDOSIS1
DIABETIC COMA1
DIABETES MELLITUS INADEQUATE CONTROL1
DEVELOPMENTAL DELAY1
DERMATOMYOSITIS1
Dermatitis psoriasiform1
DERMATITIS EXFOLIATIVE1
DERMATITIS ALLERGIC1
DEMENTIA1
Decreased immune responsiveness1
Decreased activity1
Cytomegalovirus viraemia1
Cytomegalovirus chorioretinitis1
Cutaneous lupus erythematosus1
CULTURE STOOL POSITIVE1
COVID-191
CORONARY ARTERY STENOSIS1
CORONARY ARTERY ATHEROSCLEROSIS1
Corona virus infection1
Corneal epithelium defect1
Corneal defect1
Conjunctival pallor1
CONDUCTION DISORDER1
COMPUTERISED TOMOGRAM ABNORMAL1
COLOSTOMY1
COLONIC POLYP1
COLONIC OBSTRUCTION1
COLON CANCER METASTATIC1
COLITIS ISCHAEMIC1
Clostridium test positive1
Clostridium difficile infection1
Clostridial sepsis1
Chromosome analysis abnormal1
Cholinergic syndrome1
CHOLELITHIASIS1
CHOKING1
CERVIX CARCINOMA RECURRENT1
Cervix carcinoma1
Cerebral vasoconstriction1
CEREBRAL ISCHAEMIA1
Central nervous system lesion1
Cellulitis orbital1
CATHETER RELATED INFECTION1
CATATONIA1
CATARACT1
CARDIOVASCULAR INSUFFICIENCY1
CARDIAC TAMPONADE1
CARDIAC MURMUR1
CARDIAC ENZYMES INCREASED1
CARCINOMA1
CANDIDIASIS1
Candida test positive1
CAECITIS1
C1 ESTERASE INHIBITOR DECREASED1
Burkitt's lymphoma refractory1
Burkitt's leukaemia1
BRONCHOSPASM1
BRONCHOPNEUMONIA1
Bronchiectasis1
BRONCHIAL SECRETION RETENTION1
Breast cancer metastatic1
BREAST CANCER1
BRAIN STEM SYNDROME1
BRADYCARDIA1
Bone sarcoma1
Bone pain1
BONE NEOPLASM MALIGNANT1
BONE MARROW TRANSPLANT1
Bone marrow toxicity1
Bone disorder1
Body temperature decreased1
BLOOD URIC ACID INCREASED1
BLOOD UREA DECREASED1
Blood urea1
BLOOD TRIGLYCERIDES INCREASED1
BLOOD SODIUM INCREASED1
BLOOD PRESSURE IMMEASURABLE1
BLOOD PRESSURE ABNORMAL1
BLOOD PHOSPHORUS1
Blood lactic acid decreased1
BLOOD LACTATE DEHYDROGENASE DECREASED1
Blood gases abnormal1
Blood fibrinogen increased1
Blood creatinine1
BLOOD CREATINE PHOSPHOKINASE MB INCREASED1
BLOOD CHOLESTEROL INCREASED1
BLOOD CHLORIDE INCREASED1
BLOOD CALCIUM INCREASED1
Blood blister1
BLOOD BILIRUBIN DECREASED1
BLOOD ALKALINE PHOSPHATASE DECREASED1
BLOOD ALBUMIN INCREASED1
BK virus infection1
Biopsy adrenal gland1
Bicytopenia1
BEDRIDDEN1
BASOPHIL COUNT INCREASED1
BACTERIURIA1
BACTERIAL SEPSIS1
BACTERIA URINE IDENTIFIED1
BACK INJURY1
Autonomic nervous system imbalance1
AURICULAR SWELLING1
ATTENTION DEFICIT/HYPERACTIVITY DISORDER1
ATRIOVENTRICULAR BLOCK COMPLETE1
Astrocytoma1
ASPIRATION PLEURAL CAVITY1
ASPARTATE AMINOTRANSFERASE DECREASED1
ASPARTATE AMINOTRANSFERASE ABNORMAL1
Arterial stenosis1
Arterial occlusive disease1
Application site pruritus1
Appetite disorder1
APPENDICITIS PERFORATED1
Aplastic anaemia1
AORTIC THROMBOSIS1
Anuria1
Antithrombin III decreased1
ANGIOGRAM PULMONARY ABNORMAL1
ANGIOEDEMA1
Anaplastic lymphoma kinase gene mutation1
Anal incontinence1
ANAL HAEMORRHAGE1
Anal fissure1
ANAL DISCOMFORT1
Anal abscess1
Anaemia macrocytic1
Amylase decreased1
AMAUROSIS FUGAX1
ALVEOLITIS1
Alpha haemolytic streptococcal infection1
ALANINE AMINOTRANSFERASE DECREASED1
ALANINE AMINOTRANSFERASE ABNORMAL1
AGGRESSION1
ADVERSE EVENT1
Adrenal insufficiency1
Administration related reaction1
ADENOCARCINOMA1
Acute myeloid leukaemia recurrent1
Acute leukaemia1
ACQUIRED OESOPHAGEAL WEB1
ACCIDENTAL POISONING1
Accident1
ABSCESS INTESTINAL1
ABSCESS1
ABDOMINAL WALL ABSCESS1
ABDOMINAL SYMPTOM1
ABDOMINAL MASS1
Abdominal infection1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P11387 21 DNA topoisomerase 1 TOP1_HUMAN
Q16665 12 Hypoxia-inducible factor 1-alpha HIF1A_HUMAN
Q86VL8 8600 Multidrug and toxin extrusion protein 2 S47A2_HUMAN
Q96FL8 1300 Multidrug and toxin extrusion protein 1 S47A1_HUMAN



Toxicity information:

Toxicity class: 3
Toxicity type: N/A
LD50: 50.1 mg/kg



External links:

ChEBML: CHEMBL84
DrugBank: DB01030