rivastigmine


EMA36



General information:


Withdrawn ID: EMA36
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N06DA03
Molecular Formula: C14H22N2O2
Molweight: 250.337



Withdrawal information:


Withdrawn due to drug safety reasons:No



Side-effects:

Total reported cases (submitted by medical professionals) with rivastigmine as primary suspect: 5635


Reported final outcomes:
Hospitalization (initial or prolonged): 1977
Death: 1299
Life-Threatening condition: 200
Disability: 98


Reported side-effects:

Side-effect Case number
DEATH673
FALL388
VOMITING359
NAUSEA315
CONFUSIONAL STATE313
MALAISE293
PRODUCT ADHESION ISSUE234
PNEUMONIA227
DIZZINESS227
APPLICATION SITE ERYTHEMA212
DIARRHOEA207
AGITATION198
HALLUCINATION185
ASTHENIA180
DRUG INEFFECTIVE177
DECREASED APPETITE172
AGGRESSION169
DEMENTIA ALZHEIMER'S TYPE167
CONDITION AGGRAVATED167
BRADYCARDIA164
WEIGHT DECREASED162
CEREBROVASCULAR ACCIDENT159
SYNCOPE158
MEMORY IMPAIRMENT150
DEMENTIA150
APPLICATION SITE PRURITUS149
LOSS OF CONSCIOUSNESS147
GENERAL PHYSICAL HEALTH DETERIORATION141
SOMNOLENCE135
DISORIENTATION128
GAIT DISTURBANCE124
ABNORMAL BEHAVIOUR122
PRURITUS116
TREMOR115
URINARY TRACT INFECTION114
RASH113
PYREXIA111
DYSPNOEA107
DYSPHAGIA103
Wrong technique in product usage process100
DRUG ADMINISTRATION ERROR99
DEHYDRATION98
ERYTHEMA96
INSOMNIA91
Product use issue89
HEADACHE87
FEELING ABNORMAL87
APPLICATION SITE RASH87
PARKINSON'S DISEASE86
HYPOTENSION86
SPEECH DISORDER84
DELIRIUM84
ANXIETY84
RESTLESSNESS83
PNEUMONIA ASPIRATION82
COGNITIVE DISORDER81
FEMUR FRACTURE80
FATIGUE80
HYPERTENSION78
HYPERHIDROSIS78
DEPRESSION78
MYOCARDIAL INFARCTION72
CARDIAC FAILURE72
ARRHYTHMIA69
DRUG INTOLERANCE68
DEPRESSED LEVEL OF CONSCIOUSNESS68
BLOOD PRESSURE INCREASED68
INCORRECT DOSE ADMINISTERED67
ABDOMINAL PAIN65
DRUG INTERACTION64
CARDIAC ARREST63
WRONG TECHNIQUE IN DRUG USAGE PROCESS62
Overdose61
BALANCE DISORDER61
HALLUCINATION, VISUAL57
ABASIA57
FRACTURE56
BLOOD PRESSURE DECREASED56
SKIN IRRITATION55
RENAL FAILURE55
Product use in unapproved indication54
ATRIAL FIBRILLATION53
ANAEMIA52
PAIN51
CONVULSION51
APPLICATION SITE IRRITATION49
INFECTION47
HYPERSENSITIVITY47
CARDIAC DISORDER47
GASTROINTESTINAL DISORDER46
AMNESIA45
CONSTIPATION44
MOBILITY DECREASED43
HEART RATE DECREASED43
CHEST PAIN43
URINARY INCONTINENCE42
EATING DISORDER42
APHASIA41
Seizure40
CONCOMITANT DISEASE AGGRAVATED40
BLOOD CHOLINESTERASE DECREASED40
ABDOMINAL DISCOMFORT40
Incorrect drug administration duration39
DISEASE PROGRESSION39
URINARY RETENTION38
UNRESPONSIVE TO STIMULI38
SKIN REACTION38
SEPSIS38
DYSKINESIA38
TRANSIENT ISCHAEMIC ATTACK37
Inappropriate schedule of drug administration37
DIABETES MELLITUS37
MUSCULAR WEAKNESS36
HAEMOGLOBIN DECREASED36
COMA36
APPLICATION SITE REACTION36
PSYCHOTIC DISORDER35
IRRITABILITY35
DERMATITIS CONTACT35
BLISTER35
APPLICATION SITE HYPERSENSITIVITY35
MEDICATION ERROR34
GASTROINTESTINAL HAEMORRHAGE34
CIRCULATORY COLLAPSE34
BLOOD CREATININE INCREASED34
ABDOMINAL PAIN UPPER34
NERVOUSNESS32
MOVEMENT DISORDER32
LETHARGY32
HAEMATEMESIS32
DYSSTASIA32
MARASMUS31
DRUG PRESCRIBING ERROR31
DELUSION31
RESPIRATORY FAILURE30
PAIN IN EXTREMITY30
EXTRAPYRAMIDAL DISORDER30
EPILEPSY30
ELECTROCARDIOGRAM QT PROLONGED30
ORTHOSTATIC HYPOTENSION29
NEOPLASM MALIGNANT29
HYPONATRAEMIA29
COUGH29
CARDIO-RESPIRATORY ARREST29
C-REACTIVE PROTEIN INCREASED29
APPLICATION SITE DISCOLOURATION29
NIGHTMARE28
MUSCULOSKELETAL STIFFNESS28
HYPOKINESIA28
URTICARIA27
SLEEP DISORDER27
PALLOR27
OEDEMA PERIPHERAL27
CEREBRAL INFARCTION27
ALTERED STATE OF CONSCIOUSNESS27
VERTIGO26
RENAL IMPAIRMENT26
PARANOIA26
PANCREATITIS26
LUNG DISORDER26
ASPARTATE AMINOTRANSFERASE INCREASED26
WHITE BLOOD CELL COUNT INCREASED25
TACHYCARDIA25
SALIVARY HYPERSECRETION25
PSYCHOMOTOR HYPERACTIVITY25
HEAD INJURY25
FEMORAL NECK FRACTURE25
CEREBRAL HAEMORRHAGE25
BLOOD UREA INCREASED25
BLOOD GLUCOSE INCREASED25
BLOOD ALKALINE PHOSPHATASE INCREASED25
APATHY25
ALANINE AMINOTRANSFERASE INCREASED25
WEIGHT INCREASED24
SINUS BRADYCARDIA24
RENAL FAILURE ACUTE24
PLEURAL EFFUSION24
MENTAL DISORDER24
THROMBOSIS23
PARKINSONISM23
DYSARTHRIA23
CONCOMITANT DISEASE PROGRESSION23
APPLICATION SITE VESICLES23
APPLICATION SITE PAIN23
Off label use22
MUSCLE RIGIDITY22
HYPOPHAGIA22
DISTURBANCE IN ATTENTION22
DEPRESSED MOOD22
ANGER22
PALPITATIONS21
NASOPHARYNGITIS21
MENTAL IMPAIRMENT21
HEART RATE INCREASED21
Feeding disorder21
ECZEMA21
DYSTONIA21
CRYING21
CHOKING21
Body height decreased21
SUICIDAL IDEATION20
SCRATCH20
MENTAL STATUS CHANGES20
HYPERTENSIVE CRISIS20
GASTRITIS20
CHOLINERGIC SYNDROME20
VISUAL IMPAIRMENT19
Toxicity to various agents19
THROMBOCYTOPENIA19
GAMMA-GLUTAMYLTRANSFERASE INCREASED19
CEREBRAL ATROPHY19
ATRIOVENTRICULAR BLOCK19
SKIN EXFOLIATION18
RECTAL HAEMORRHAGE18
MUSCLE SPASMS18
MOTOR DYSFUNCTION18
LEUKOCYTOSIS18
JAUNDICE18
HIP FRACTURE18
GASTRIC DISORDER18
ELECTROCARDIOGRAM ABNORMAL18
DERMATITIS ALLERGIC18
CHRONIC OBSTRUCTIVE PULMONARY DISEASE18
CHEST DISCOMFORT18
CARDIAC FAILURE CONGESTIVE18
BACK PAIN18
RETCHING17
PULMONARY OEDEMA17
Product administration interrupted17
PRESYNCOPE17
OXYGEN SATURATION DECREASED17
Multiple organ dysfunction syndrome17
MOOD ALTERED17
INFLUENZA17
INCOHERENT17
HEMIPLEGIA17
DERMATITIS BULLOUS17
APPLICATION SITE SWELLING17
APPARENT DEATH17
ANGINA PECTORIS17
PULMONARY EMBOLISM16
POLLAKIURIA16
Peripheral swelling16
PEMPHIGOID16
NERVOUS SYSTEM DISORDER16
MYOCLONUS16
MIOSIS16
MELAENA16
LUNG NEOPLASM MALIGNANT16
CONTUSION16
Blood sodium decreased16
ACCIDENTAL OVERDOSE16
ABDOMINAL DISTENSION16
SUBDURAL HAEMATOMA15
Skin disorder15
RIB FRACTURE15
RESPIRATORY DISORDER15
RENAL DISORDER15
HEART RATE IRREGULAR15
HAEMORRHAGE15
HAEMATOCRIT DECREASED15
HAEMATOCHEZIA15
Gait inability15
DEMENTIA WITH LEWY BODIES15
ATRIOVENTRICULAR BLOCK COMPLETE15
ASTHMA15
ASPIRATION15
APPLICATION SITE DERMATITIS15
Underdose14
SEDATION14
SCREAMING14
RED BLOOD CELL COUNT DECREASED14
Product prescribing error14
MINI MENTAL STATUS EXAMINATION ABNORMAL14
INTERNATIONAL NORMALISED RATIO INCREASED14
HYPOKALAEMIA14
HYPOAESTHESIA14
HALLUCINATION, AUDITORY14
FEAR14
ELECTROLYTE IMBALANCE14
DRUG ADMINISTERED AT INAPPROPRIATE SITE14
COLON CANCER14
COLD SWEAT14
CHOLELITHIASIS14
CHILLS14
BUNDLE BRANCH BLOCK LEFT14
BRADYKINESIA14
BLOOD PRESSURE SYSTOLIC INCREASED14
ATRIOVENTRICULAR BLOCK SECOND DEGREE14
Acute kidney injury14
ACTIVITIES OF DAILY LIVING IMPAIRED14
ABNORMAL DREAMS14
SWELLING13
SUDDEN DEATH13
STATUS EPILEPTICUS13
SEPTIC SHOCK13
RASH GENERALISED13
PRODUCT SUBSTITUTION ISSUE13
PLATELET COUNT DECREASED13
NEUROLEPTIC MALIGNANT SYNDROME13
MANIA13
MALNUTRITION13
LIVER DISORDER13
Lack of application site rotation13
HYPOGLYCAEMIA13
FAECAL INCONTINENCE13
EPISTAXIS13
DYSPEPSIA13
DRUG ERUPTION13
BLOOD POTASSIUM DECREASED13
BLOOD CREATINE PHOSPHOKINASE INCREASED13
ACUTE MYOCARDIAL INFARCTION13
VASCULAR DEMENTIA12
SKIN LESION12
SKIN DISCOLOURATION12
RHABDOMYOLYSIS12
PRODUCT QUALITY ISSUE12
PLEUROTHOTONUS12
INJURY12
INCONTINENCE12
Ileus12
HYPOACUSIS12
Hepatic function abnormal12
HEMIPARESIS12
DECUBITUS ULCER12
CHOLESTASIS12
BRONCHITIS12
BRADYARRHYTHMIA12
BLOOD PRESSURE FLUCTUATION12
BLINDNESS12
AKINESIA12
Wound11
WHEEZING11
VENTRICULAR EXTRASYSTOLES11
TOXIC SKIN ERUPTION11
SHOCK11
RESPIRATORY ARREST11
OEDEMA11
MACULAR DEGENERATION11
HYDROCEPHALUS11
HERPES ZOSTER11
HEPATITIS11
HEPATIC ENZYME INCREASED11
DYSENTERY11
DERMATITIS11
Deafness11
CATATONIA11
CARDIAC PACEMAKER INSERTION11
BLOOD LACTATE DEHYDROGENASE INCREASED11
BLOOD ALBUMIN DECREASED11
SWELLING FACE10
RASH PRURITIC10
RASH MACULAR10
Product dose omission issue10
POSTURE ABNORMAL10
PARAESTHESIA10
LOWER LIMB FRACTURE10
LIVER FUNCTION TEST ABNORMAL10
LIPASE INCREASED10
Labelled drug-drug interaction medication error10
INFLAMMATION10
HYPERKALAEMIA10
HYPERGLYCAEMIA10
GASTROENTERITIS10
FEELING COLD10
FAECES DISCOLOURED10
DYSURIA10
DRY SKIN10
DECREASED ACTIVITY10
CYTOLYTIC HEPATITIS10
COMMUNICATION DISORDER10
CELLULITIS10
ANOREXIA10
ANGIOEDEMA10
Accident10
UPPER GASTROINTESTINAL HAEMORRHAGE9
TORSADE DE POINTES9
STRESS9
RESPIRATORY DISTRESS9
PRURITUS GENERALISED9
PANCREATITIS ACUTE9
OSTEOARTHRITIS9
NEUTROPHIL COUNT INCREASED9
MUSCLE CONTRACTIONS INVOLUNTARY9
MULTI-ORGAN FAILURE9
LUNG INFECTION9
Impulsive behaviour9
HYPOXIA9
GRAND MAL CONVULSION9
GASTRIC ULCER9
EXCORIATION9
EMPHYSEMA9
Drug-induced liver injury9
DRUG HYPERSENSITIVITY9
DRUG DISPENSING ERROR9
CARDIOVASCULAR DISORDER9
CARDIOMYOPATHY9
CARDIOMEGALY9
ARTHRALGIA9
APPLICATION SITE INFLAMMATION9
Anal incontinence9
Accidental exposure to product9
VENTRICULAR TACHYCARDIA8
SUICIDE ATTEMPT8
SKIN HAEMORRHAGE8
SICK SINUS SYNDROME8
SENILE DEMENTIA8
RESPIRATORY TRACT INFECTION8
RASH PAPULAR8
PRODUCTIVE COUGH8
Product administration error8
PETIT MAL EPILEPSY8
PARALYSIS8
PANIC ATTACK8
MITRAL VALVE INCOMPETENCE8
LOWER RESPIRATORY TRACT INFECTION8
LOGORRHOEA8
INTESTINAL OBSTRUCTION8
Inguinal hernia8
INFARCTION8
HYPOTONIA8
HYPERSOMNIA8
HYPERNATRAEMIA8
HAEMORRHAGIC STROKE8
HAEMATURIA8
FEELING HOT8
FAECALOMA8
EOSINOPHILIA8
ENCEPHALOPATHY8
Drug dependence8
DIABETES MELLITUS INADEQUATE CONTROL8
CYANOSIS8
CREATININE RENAL CLEARANCE DECREASED8
COORDINATION ABNORMAL8
BREAST CANCER8
BRAIN OEDEMA8
BEHAVIOURAL AND PSYCHIATRIC SYMPTOMS OF DEMENTIA8
ATRIOVENTRICULAR BLOCK FIRST DEGREE8
ASPIRATION BRONCHIAL8
APHAGIA8
Acute respiratory failure8
UPPER LIMB FRACTURE7
TRANSAMINASES INCREASED7
TORTICOLLIS7
Therapy cessation7
SURGERY7
STUPOR7
SPINAL COMPRESSION FRACTURE7
SKIN EROSION7
SINUS ARREST7
RASH ERYTHEMATOUS7
PYELONEPHRITIS7
Psychotic symptom7
PSYCHIATRIC SYMPTOM7
PORIOMANIA7
PERIPHERAL COLDNESS7
PANCREATIC CARCINOMA7
Osteoporosis7
NO ADVERSE EVENT7
MYALGIA7
MUSCLE TWITCHING7
MIDDLE INSOMNIA7
LACRIMATION INCREASED7
JOINT SWELLING7
ISCHAEMIC STROKE7
HYPOTHERMIA7
Hepatocellular injury7
Head discomfort7
HALLUCINATIONS, MIXED7
HAEMATOMA7
Glaucoma7
GASTRITIS EROSIVE7
FLUID RETENTION7
EYE DISORDER7
EOSINOPHIL COUNT INCREASED7
EMOTIONAL DISORDER7
DYSPHONIA7
COLITIS7
CARDIOPULMONARY FAILURE7
CACHEXIA7
BLOOD GLUCOSE DECREASED7
BLOOD BILIRUBIN INCREASED7
BEDRIDDEN7
AUTONOMIC NERVOUS SYSTEM IMBALANCE7
ATELECTASIS7
APPLICATION SITE URTICARIA7
UPPER RESPIRATORY TRACT INFECTION6
TOOTH LOSS6
TINNITUS6
THINKING ABNORMAL6
Terminal state6
TACHYPNOEA6
SUBILEUS6
STEVENS-JOHNSON SYNDROME6
SKIN PLAQUE6
SKIN BURNING SENSATION6
ROAD TRAFFIC ACCIDENT6
PURPURA6
PERSONALITY CHANGE6
PARESIS6
OESOPHAGITIS6
OESOPHAGEAL ULCER6
OESOPHAGEAL DILATATION6
Nosocomial infection6
Neurodegenerative disorder6
MYOCARDIAL ISCHAEMIA6
LYMPHOCYTE COUNT DECREASED6
LIMB INJURY6
LIMB DISCOMFORT6
LACUNAR INFARCTION6
JOINT INJURY6
Ischaemia6
Inappropriate schedule of product administration6
HYPERTONIA6
HEPATITIS CHOLESTATIC6
GENERALISED ERYTHEMA6
GASTROOESOPHAGEAL REFLUX DISEASE6
GASTROINTESTINAL SOUNDS ABNORMAL6
GASTROINTESTINAL INFECTION6
GASTRIC CANCER6
FACIAL BONES FRACTURE6
EYE MOVEMENT DISORDER6
EXTRASYSTOLES6
Expired product administered6
ERYSIPELAS6
DUODENAL ULCER6
DROOLING6
DIVERTICULITIS6
DISSEMINATED INTRAVASCULAR COAGULATION6
DISCOMFORT6
DIET REFUSAL6
Cystitis6
CORONARY ARTERY DISEASE6
CEREBRAL ISCHAEMIA6
BUNDLE BRANCH BLOCK RIGHT6
BLOOD POTASSIUM INCREASED6
BENIGN PROSTATIC HYPERPLASIA6
APPLICATION SITE BURN6
ACCIDENTAL EXPOSURE6
VISUAL ACUITY REDUCED5
VISION BLURRED5
VIRAL INFECTION5
VAGINAL HAEMORRHAGE5
Urosepsis5
Underweight5
ULCER5
THERAPEUTIC RESPONSE UNEXPECTED5
SWOLLEN TONGUE5
SUPRAVENTRICULAR EXTRASYSTOLES5
SUBARACHNOID HAEMORRHAGE5
STAPHYLOCOCCAL INFECTION5
SOPOR5
SOCIAL AVOIDANT BEHAVIOUR5
SLOW RESPONSE TO STIMULI5
Skin swelling5
Skin cancer5
SINUS TACHYCARDIA5
SCHIZOPHRENIA5
Resting tremor5
RENAL FAILURE CHRONIC5
RASH MACULO-PAPULAR5
RALES5
PULMONARY FIBROSIS5
PROSTATE CANCER5
POOR QUALITY SLEEP5
PIGMENTATION DISORDER5
PARKINSONIAN GAIT5
PAPULE5
NEPHROLITHIASIS5
NEGATIVISM5
NECK PAIN5
MYDRIASIS5
Mood swings5
MICTURITION URGENCY5
Lymphoma5
LIP SWELLING5
Labyrinthitis5
INTERSTITIAL LUNG DISEASE5
INCORRECT ROUTE OF DRUG ADMINISTRATION5
ILLUSION5
HYPOTHYROIDISM5
HYPOREFLEXIA5
HICCUPS5
HIATUS HERNIA5
Hernia5
Hand fracture5
Generalised tonic-clonic seizure5
GASTROINTESTINAL PAIN5
Frontotemporal dementia5
Facial paralysis5
ERYTHEMA MULTIFORME5
DUODENITIS5
DRY MOUTH5
DRUG WITHDRAWAL SYNDROME5
DRUG TOXICITY5
DRUG LEVEL INCREASED5
COLITIS ULCERATIVE5
Chronic kidney disease5
CHROMATURIA5
CATARACT5
Cardiac failure acute5
BRONCHOPNEUMONIA5
BRONCHIAL OBSTRUCTION5
BODY TEMPERATURE INCREASED5
BLOOD PRESSURE ABNORMAL5
BLOOD CHOLESTEROL INCREASED5
BLOOD CALCIUM DECREASED5
Bladder disorder5
BLADDER CANCER5
ATRIAL FLUTTER5
ARTERIOSCLEROSIS5
Application site mass5
Application site haemorrhage5
APPLICATION SITE EXFOLIATION5
APNOEA5
ALOPECIA5
AGNOSIA5
Accessory cardiac pathway5
WRIST FRACTURE4
VASCULITIS4
URINE OUTPUT DECREASED4
Unmasking of previously unidentified disease4
TREATMENT NONCOMPLIANCE4
TARDIVE DYSKINESIA4
SPUTUM RETENTION4
SOMNAMBULISM4
SLUGGISHNESS4
SKIN ULCER4
Skin atrophy4
RHINORRHOEA4
RESPIRATORY RATE INCREASED4
RESPIRATORY RATE DECREASED4
RESPIRATORY DEPRESSION4
RENAL CYST4
Renal cancer4
PULSE ABSENT4
PULMONARY CONGESTION4
Product packaging issue4
PHARYNGITIS4
PERIPHERAL ARTERIAL OCCLUSIVE DISEASE4
PEMPHIGUS4
PARTIAL SEIZURES4
Organ failure4
On and off phenomenon4
OLIGURIA4
NECROSIS4
Musculoskeletal pain4
MUSCULOSKELETAL DISCOMFORT4
Muscle tightness4
Muscle atrophy4
MOANING4
METASTATIC NEOPLASM4
METASTASIS4
METASTASES TO LIVER4
LUNG CONSOLIDATION4
Lumbar vertebral fracture4
LEUKOPENIA4
LEUKAEMIA4
LEFT VENTRICULAR HYPERTROPHY4
Laziness4
KIDNEY INFECTION4
INCREASED BRONCHIAL SECRETION4
Incorrect product administration duration4
Immune thrombocytopenic purpura4
IMMOBILE4
Illness4
ILL-DEFINED DISORDER4
HYPOALBUMINAEMIA4
HYPERSEXUALITY4
HYPERCALCAEMIA4
HUMERUS FRACTURE4
HEPATOTOXICITY4
HEPATIC FAILURE4
HEPATIC ENCEPHALOPATHY4
HEAT ILLNESS4
Hearing impaired4
Haemoptysis4
GENERAL PHYSICAL CONDITION ABNORMAL4
GASTROENTERITIS VIRAL4
GASTRIC ULCER HAEMORRHAGE4
GALLBLADDER DISORDER4
Functional gastrointestinal disorder4
FREEZING PHENOMENON4
Foot fracture4
FOAMING AT MOUTH4
FLUSHING4
Fluid intake reduced4
FLATULENCE4
FLANK PAIN4
ESCHERICHIA URINARY TRACT INFECTION4
ELECTROCARDIOGRAM PR PROLONGATION4
EJECTION FRACTION DECREASED4
ECCHYMOSIS4
DYSGEUSIA4
DIPLOPIA4
DIASTOLIC DYSFUNCTION4
DERMATITIS EXFOLIATIVE4
DELUSIONAL DISORDER, UNSPECIFIED TYPE4
DECREASED INTEREST4
CUTANEOUS LUPUS ERYTHEMATOSUS4
CRANIOCEREBRAL INJURY4
Compression fracture4
COMPLETED SUICIDE4
COMA SCALE ABNORMAL4
COLITIS ISCHAEMIC4
CLONUS4
CHOLECYSTITIS4
Chikungunya virus infection4
CEREBROVASCULAR DISORDER4
CEREBRAL THROMBOSIS4
Cerebral disorder4
CARDIOVERSION4
CARDIAC VALVE DISEASE4
CARDIAC MURMUR4
BURNING SENSATION4
BRONCHOSPASM4
BRAIN NEOPLASM4
BODY TEMPERATURE DECREASED4
BLOOD TRIGLYCERIDES INCREASED4
BLOOD PRESSURE DIASTOLIC DECREASED4
BLOOD GLUCOSE FLUCTUATION4
BILE DUCT OBSTRUCTION4
BARRETT'S OESOPHAGUS4
ASPHYXIA4
ASCITES4
ANAPHYLACTIC SHOCK4
ANAPHYLACTIC REACTION4
AGEUSIA4
Affect lability4
ACUTE PULMONARY OEDEMA4
ABNORMAL FAECES4
Wrong patient received product3
Withdrawal syndrome3
White blood cell count decreased3
Vitamin D deficiency3
VITAMIN B12 DEFICIENCY3
VISUAL DISTURBANCE3
VENTRICULAR FIBRILLATION3
VASCULAR FRAGILITY3
Varices oesophageal3
URINARY TRACT DISORDER3
UMBILICAL HERNIA3
Tuberculosis3
TROPONIN INCREASED3
TRAUMATIC HAEMATOMA3
THROMBOPHLEBITIS3
TENSION3
SUPRAVENTRICULAR TACHYCARDIA3
Stubbornness3
Staring3
SPUTUM INCREASED3
SPINAL OSTEOARTHRITIS3
Spinal fracture3
Spinal deformity3
Snoring3
SNEEZING3
SLEEP APNOEA SYNDROME3
SKULL FRACTURE3
Skin wound3
SKIN WARM3
SKIN NECROSIS3
SINUS ARRHYTHMIA3
Sexually inappropriate behaviour3
SERUM FERRITIN INCREASED3
SENSORY LOSS3
Scoliosis3
Scintillating scotoma3
SCAR3
REGURGITATION3
Reduced facial expression3
RED CELL DISTRIBUTION WIDTH INCREASED3
PULSELESS ELECTRICAL ACTIVITY3
PULMONARY TUBERCULOSIS3
PROTHROMBIN TIME PROLONGED3
PROSTATIC OPERATION3
PROSTATIC DISORDER3
Product supply issue3
Product residue present3
Product measured potency issue3
Poisoning3
PLATELET COUNT INCREASED3
Plasma cell myeloma3
Physical deconditioning3
PHLEBITIS3
PERSONALITY DISORDER3
Peripheral vascular disorder3
Pelvic fracture3
PANCREATITIS NECROTISING3
OXYGEN SATURATION ABNORMAL3
ORAL PAIN3
NYSTAGMUS3
NIGHT SWEATS3
NEUTROPHILIA3
Neuropsychiatric symptoms3
NEOPLASM PROGRESSION3
Negative thoughts3
NECK INJURY3
NASAL CONGESTION3
MYELODYSPLASTIC SYNDROME3
MONOCYTE COUNT INCREASED3
Migraine with aura3
MICTURITION DISORDER3
Metastases to lung3
Metabolic acidosis3
Mastication disorder3
MASKED FACIES3
MALLORY-WEISS SYNDROME3
MAJOR DEPRESSION3
Lymphocyte stimulation test positive3
LUNG INFILTRATION3
LOSS OF CONTROL OF LEGS3
Local swelling3
LISTLESS3
Ligament sprain3
Large intestine polyp3
Intentional product misuse3
INTENTIONAL OVERDOSE3
INFLUENZA LIKE ILLNESS3
Increased appetite3
HYPOVOLAEMIA3
HYPERVENTILATION3
HYPERTHERMIA3
HOT FLUSH3
Homicidal ideation3
Hepatic cirrhosis3
HAEMORRHAGE SUBCUTANEOUS3
HAEMORRHAGE INTRACRANIAL3
HAEMODIALYSIS3
GASTRIC HAEMORRHAGE3
Frustration tolerance decreased3
FREQUENT BOWEL MOVEMENTS3
FAILURE TO THRIVE3
Faeces soft3
Face oedema3
EYELID OEDEMA3
Eye swelling3
EYE INJURY3
EUPHORIC MOOD3
ENDOTRACHEAL INTUBATION3
ELECTROENCEPHALOGRAM ABNORMAL3
DYSPHEMIA3
DYSGRAPHIA3
Dry eye3
DRUG EFFECT DECREASED3
DIVERTICULUM3
DISTURBANCE IN SOCIAL BEHAVIOUR3
Distractibility3
DIASTOLIC HYPERTENSION3
DIARRHOEA HAEMORRHAGIC3
Device adhesion issue3
DEEP VEIN THROMBOSIS3
CORONARY ARTERY STENOSIS3
CORONARY ARTERY OCCLUSION3
COMPUTERISED TOMOGRAM ABNORMAL3
COGNITIVE DETERIORATION3
CHOLECYSTITIS ACUTE3
CHOLECYSTECTOMY3
CHEST X-RAY ABNORMAL3
CEREBRAL ARTERY EMBOLISM3
Central nervous system lesion3
CARDIOVASCULAR INSUFFICIENCY3
CARDIAC HYPERTROPHY3
Cardiac failure chronic3
CARDIAC ENZYMES INCREASED3
BUNDLE BRANCH BLOCK3
BRAIN NATRIURETIC PEPTIDE INCREASED3
BRAIN INJURY3
Bradyphrenia3
BONE PAIN3
BLOOD SODIUM INCREASED3
BLOOD PRESSURE SYSTOLIC DECREASED3
Blood glucose abnormal3
BLOOD AMYLASE INCREASED3
BLADDER OBSTRUCTION3
BLADDER CATHETERISATION3
Bipolar disorder3
Bile duct cancer3
Behaviour disorder3
BACTERIAL INFECTION3
BACK INJURY3
Atrophy3
ARTHRITIS3
ARTERIOSCLEROSIS CORONARY ARTERY3
APPLICATION SITE SCAR3
Application site scab3
APPLICATION SITE OEDEMA3
Application site injury3
APPLICATION SITE EROSION3
APPLICATION SITE DISCOMFORT3
APPLICATION SITE BLEEDING3
AORTIC VALVE INCOMPETENCE3
Anuria3
ANTICHOLINERGIC SYNDROME3
ANGIOPATHY3
AMMONIA INCREASED3
ALCOHOLISM3
AKATHISIA3
ADRENAL INSUFFICIENCY3
ACUTE PSYCHOSIS3
ACUTE CORONARY SYNDROME3
Abdominal tenderness3
Wrong patient received medication2
WOUND SECRETION2
Weight abnormal2
Waldenstrom's macroglobulinaemia2
VOMITING PROJECTILE2
Ventricular tachyarrhythmia2
VENOUS THROMBOSIS LIMB2
VENOUS THROMBOSIS2
VENOUS OCCLUSION2
VASCULAR OCCLUSION2
Vascular encephalopathy2
URINE ODOUR ABNORMAL2
URINARY TRACT OBSTRUCTION2
URINARY HESITATION2
UNEVALUABLE EVENT2
ULCER HAEMORRHAGE2
TRIGEMINAL NEURALGIA2
TRICUSPID VALVE INCOMPETENCE2
TOXIC ENCEPHALOPATHY2
TOOTH DISORDER2
Tonic convulsion2
Tongue disorder2
TIC2
Throat tightness2
Thoracic vertebral fracture2
THIRST2
Therapy non-responder2
Therapeutic response shortened2
Therapeutic response increased2
Thalamus haemorrhage2
TEARFULNESS2
SYSTEMIC INFLAMMATORY RESPONSE SYNDROME2
Systemic infection2
SYNCOPE VASOVAGAL2
SUTURE INSERTION2
SUSPICIOUSNESS2
SUDDEN CARDIAC DEATH2
Substance-induced psychotic disorder2
SUBDURAL HAEMORRHAGE2
SUBCUTANEOUS ABSCESS2
Spondylolisthesis2
Spinal pain2
SPINAL DISORDER2
SPINAL COLUMN INJURY2
SLEEP TALKING2
Skin sensitisation2
SKIN OEDEMA2
SKIN LACERATION2
Skin abrasion2
SINUSITIS2
Sinus node dysfunction2
SINOATRIAL BLOCK2
SIGMOIDITIS2
Shock haemorrhagic2
SEROTONIN SYNDROME2
Secretion discharge2
Seborrhoea2
Sciatica2
SCAB2
SALIVA ALTERED2
RESUSCITATION2
RESPIRATORY ALKALOSIS2
REPETITIVE SPEECH2
RED CELL DISTRIBUTION WIDTH DECREASED2
RED BLOOD CELL SEDIMENTATION RATE INCREASED2
RECTAL CANCER2
Reading disorder2
RASH MORBILLIFORM2
RAPID EYE MOVEMENTS SLEEP ABNORMAL2
RADIUS FRACTURE2
Quality of life decreased2
QUADRIPLEGIA2
Pyelonephritis acute2
PUPIL FIXED2
Pulmonary sepsis2
Pulmonary hypertension2
PULMONARY ARTERIAL PRESSURE INCREASED2
Psychotic behaviour2
PSYCHOMOTOR RETARDATION2
PSORIASIS2
Prurigo2
PROTEIN TOTAL DECREASED2
Prostatomegaly2
Product used for unknown indication2
Product colour issue2
Product administered at inappropriate site2
POSTICTAL STATE2
Portal vein occlusion2
POLYP2
POLYNEUROPATHY2
PATELLA FRACTURE2
PAROXYSMAL ARRHYTHMIA2
PARKINSONIAN REST TREMOR2
PARAPLEGIA2
PARAMNESIA2
Paraesthesia oral2
Paradoxical drug reaction2
PANIC REACTION2
PANIC DISORDER2
Pancytopenia2
Pain of skin2
Overweight2
Osteomyelitis2
Orthopnoea2
ORAL MUCOSA EROSION2
Oral discomfort2
OESOPHAGITIS ULCERATIVE2
OEDEMA MUCOSAL2
Obstruction gastric2
OBSESSIVE-COMPULSIVE DISORDER2
Obesity2
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL2
NORMAL PRESSURE HYDROCEPHALUS2
Nocturia2
NO THERAPEUTIC RESPONSE2
NEUTROPHIL COUNT DECREASED2
NEUTROPENIA2
NEUROLOGICAL DECOMPENSATION2
NEUROGENIC BLADDER2
Neoplasm2
MYOGLOBIN BLOOD INCREASED2
Myoclonic epilepsy2
MUTISM2
Musculoskeletal chest pain2
MUSCLE SPASTICITY2
Muscle injury2
MUSCLE DISORDER2
Muscle contracture2
Multi-organ disorder2
MONOPLEGIA2
Migraine2
METASTASES TO LYMPH NODES2
METABOLIC ENCEPHALOPATHY2
Medication residue present2
MECHANICAL VENTILATION2
Mass2
Malignant neoplasm progression2
Lower gastrointestinal haemorrhage2
Localised infection2
Liver injury2
LIMB DEFORMITY2
LICHEN PLANUS2
LIBIDO INCREASED2
LEFT VENTRICULAR DYSFUNCTION2
LARYNGEAL OEDEMA2
LACK OF SPONTANEOUS SPEECH2
Laceration2
KNEE OPERATION2
KLEBSIELLA INFECTION2
JOINT DISLOCATION2
Jaundice cholestatic2
ISCHAEMIC CARDIOMYOPATHY2
INTRAOCULAR PRESSURE INCREASED2
INTRACRANIAL PRESSURE INCREASED2
INTRACARDIAC THROMBUS2
INTESTINAL ISCHAEMIA2
INTESTINAL HAEMORRHAGE2
INTERVERTEBRAL DISC DISORDER2
Intentional self-injury2
Intentional product use issue2
INITIAL INSOMNIA2
INFREQUENT BOWEL MOVEMENTS2
Incorrect product dosage form administered2
INCORRECT DRUG ADMINISTRATION RATE2
Incorrect dose administered by product2
IMPULSE-CONTROL DISORDER2
IMPAIRED SELF-CARE2
Ileus paralytic2
HYPOXIC-ISCHAEMIC ENCEPHALOPATHY2
Hypotonic-hyporesponsive episode2
Hyporesponsive to stimuli2
Hypopnoea2
HYPOMAGNESAEMIA2
HYPERVIGILANCE2
Hypersensitivity vasculitis2
Hyperkinesia2
Hyperkeratosis2
HYPERCAPNIA2
HYPERAMMONAEMIA2
Hyperaesthesia2
Hospitalisation2
HIP ARTHROPLASTY2
HEPATOMEGALY2
Hepatocellular carcinoma2
HEPATITIS ACUTE2
HEPATIC STEATOSIS2
HEPATIC NEOPLASM2
Hepatic infection2
Hepatic cancer2
HELICOBACTER GASTRITIS2
Hand deformity2
HAIR GROWTH ABNORMAL2
HAEMORRHOIDS2
HAEMORRHAGE URINARY TRACT2
HAEMODYNAMIC INSTABILITY2
GRIMACING2
Glomerular filtration rate increased2
GLOMERULAR FILTRATION RATE DECREASED2
GAZE PALSY2
GASTROINTESTINAL TUBE INSERTION2
GASTROINTESTINAL NECROSIS2
GASTROINTESTINAL HYPOMOTILITY2
Gait apraxia2
Food poisoning2
FOLATE DEFICIENCY2
FIBROMYALGIA2
FIBRIN D DIMER INCREASED2
FEELING JITTERY2
FEAR OF DEATH2
FAECES PALE2
FACIAL SPASM2
FACIAL PALSY2
FACE INJURY2
EYELID PTOSIS2
Eye pruritus2
EYE PAIN2
Eye infection2
EYE HAEMORRHAGE2
EROSIVE OESOPHAGITIS2
Epigastric discomfort2
Embolism2
ELEVATED MOOD2
ELECTROCARDIOGRAM T WAVE AMPLITUDE DECREASED2
ELECTROCARDIOGRAM QRS COMPLEX SHORTENED2
Electrocardiogram PR shortened2
Dyspnoea exertional2
Dysphoria2
DYSLALIA2
Duodenitis haemorrhagic2
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS2
Drug ineffective for unapproved indication2
Drug effect incomplete2
DRUG DOSE OMISSION2
Drug dispensed to wrong patient2
DIZZINESS POSTURAL2
Diverticulum intestinal haemorrhagic2
Diverticulum intestinal2
DISSOCIATIVE FUGUE2
Disinhibition2
Disease complication2
Diplegia2
DILATATION VENTRICULAR2
Diabetic ketoacidosis2
Diabetic coma2
DEPENDENCE2
Dengue fever2
Decreased immune responsiveness2
Daydreaming2
CYST2
Cutaneous symptom2
COVID-192
Coronary artery embolism2
Contraindicated product administered2
CONJUNCTIVITIS2
CONCUSSION2
COLONOSCOPY2
Colitis microscopic2
COAGULOPATHY2
Clavicle fracture2
CIRCADIAN RHYTHM SLEEP DISORDER2
Cholangitis acute2
Cholangitis2
Cervical vertebral fracture2
CEREBRAL VENTRICLE DILATATION2
Cerebral palsy2
CEREBRAL ARTERY OCCLUSION2
Catarrh2
CAROTID ARTERY OCCLUSION2
Cardiac output decreased2
CARDIAC FIBRILLATION2
BRONCHOPNEUMOPATHY2
BRONCHIAL DISORDER2
BOWEL MOVEMENT IRREGULARITY2
BONE DISORDER2
Bone cancer2
Blood urine present2
BLOOD URINE2
BLOOD POTASSIUM ABNORMAL2
BLOOD PH DECREASED2
Blood immunoglobulin G increased2
BLOOD IMMUNOGLOBULIN E INCREASED2
BLOOD FIBRINOGEN INCREASED2
BLOOD CREATINE PHOSPHOKINASE DECREASED2
BLOOD CREATINE INCREASED2
Blood cholesterol abnormal2
BLOOD CHLORIDE DECREASED2
BLINDNESS UNILATERAL2
Bladder neoplasm2
Bladder dysfunction2
BILIARY DILATATION2
Basal ganglion degeneration2
Basal cell carcinoma2
Azotaemia2
ATAXIA2
ASPERGILLUS TEST POSITIVE2
Arthropod bite2
ARTHROPATHY2
APRAXIA2
Application site laceration2
APPLICATION SITE INFECTION2
APPLICATION SITE ECZEMA2
Application site acne2
APPETITE DISORDER2
AORTIC CALCIFICATION2
AORTIC ANEURYSM2
ANOSMIA2
ACUTE RESPIRATORY DISTRESS SYNDROME2
ACUTE PRERENAL FAILURE2
Acne2
Abortion spontaneous2
ABDOMINAL PAIN LOWER2
Zika virus infection1
Yawning1
X-RAY ABNORMAL1
Wrong technique in device usage process1
Wrong drug administered1
Wound infection1
Wound haemorrhage1
Wound complication1
White blood cell count abnormal1
WHEELCHAIR USER1
WEIGHT LOSS POOR1
WAXY FLEXIBILITY1
WALKING DISABILITY1
WALKING AID USER1
Volvulus1
Vocal cord disorder1
Vitreous haemorrhage1
Vitamin D decreased1
VITAMIN B12 DECREASED1
Vitamin B1 deficiency1
Viral diarrhoea1
Victim of abuse1
VESTIBULAR NEURONITIS1
VESTIBULAR DISORDER1
Vertigo positional1
Vertebrobasilar insufficiency1
Vertebral wedging1
VERTEBRAL INJURY1
VERBAL ABUSE1
VENTRICULAR HYPERTROPHY1
VENTRICULAR ASYSTOLE1
Venous injury1
VENA CAVA FILTER INSERTION1
Vein disorder1
Vasospasm1
VASOGENIC CEREBRAL OEDEMA1
VASODILATATION1
Vascular resistance systemic increased1
VASCULAR CALCIFICATION1
Varicose vein ruptured1
Varicose vein1
VAGINAL INFECTION1
UTERINE LEIOMYOMA1
Uterine cancer1
URINE PROTEIN/CREATININE RATIO INCREASED1
Urine oxalate1
Urine output increased1
URINE COLOUR ABNORMAL1
URINE ANALYSIS ABNORMAL1
URINE AMYLASE INCREASED1
Urinary tract pain1
URINARY TRACT OPERATION1
URINARY TRACT INFECTION STAPHYLOCOCCAL1
Urinary tract infection bacterial1
URINARY BLADDER POLYP1
Urge incontinence1
Urethritis1
Urethral stenosis1
Urethral obstruction1
Urethral discharge1
Urethral dilatation1
UNRESPONSIVE TO PAIN STIMULI1
Type I hypersensitivity1
Type 2 diabetes mellitus1
Tumour marker increased1
Troponin T increased1
Troponin I increased1
Trismus1
Trichotillomania1
TRAUMATIC INTRACRANIAL HAEMORRHAGE1
TRAUMATIC BRAIN INJURY1
TRANSFUSION1
TRANSFERRIN SATURATION INCREASED1
TRANSFERRIN DECREASED1
Trance1
Tracheobronchitis1
Toxic epidermal necrolysis1
Tourette's disorder1
TOTAL CHOLESTEROL/HDL RATIO ABNORMAL1
Tooth infection1
Tooth fracture1
Tooth discolouration1
Tongue movement disturbance1
TONGUE HAEMORRHAGE1
Tongue coated1
TONGUE BITING1
Tinea pedis1
Thyroid function test abnormal1
Thyroid disorder1
THROMBOTIC CEREBRAL INFARCTION1
THROMBIN TIME ABNORMAL1
Thought blocking1
THORACIC CAVITY DRAINAGE1
Thermal burn1
Therapeutic response decreased1
Therapeutic response changed1
Therapeutic product effect incomplete1
THERAPEUTIC PRODUCT CONTAMINATION1
Therapeutic drug monitoring analysis not performed1
TESTICULAR SWELLING1
Testicular pain1
Tendon rupture1
TACITURNITY1
Tachyarrhythmia1
Superinfection bacterial1
SUPERINFECTION1
Superficial injury of eye1
SUNBURN1
Suffocation feeling1
SUDDEN ONSET OF SLEEP1
Substance abuse1
Subcutaneous emphysema1
STRIDOR1
Stress fracture1
Stress cardiomyopathy1
Streptococcal infection1
STOMACH DISCOMFORT1
Stoma site reaction1
Stoma site pain1
Stoma site irritation1
Stoma site infection1
Stoma site extravasation1
Stoma site erythema1
Stoma site discomfort1
Stoma site discharge1
Still's disease1
Sternal fracture1
Squamous cell carcinoma1
SPONDYLITIS1
Splenomegaly1
SPLENITIS1
Splenic rupture1
SPLENIC CALCIFICATION1
SPLEEN DISORDER1
Spinal cord disorder1
Spinal column stenosis1
Soliloquy1
Soft tissue mass1
SMOOTH MUSCLE ANTIBODY1
SLEEP TERROR1
Sleep inertia1
Skin papilloma1
SKIN NEOPLASM EXCISION1
Skin hypertrophy1
Skin hyperpigmentation1
Skin fragility1
Skin fissures1
Skin adhesion1
Sjogren's syndrome1
Sinus headache1
SINUS DISORDER1
SINUS CONGESTION1
SEXUAL DYSFUNCTION1
Seronegative arthritis1
Sensory disturbance1
Sensitivity to weather change1
Sensitisation1
SENSE OF OPPRESSION1
SENSATION OF PRESSURE1
SENSATION OF HEAVINESS1
Self-injurious ideation1
SELF INJURIOUS BEHAVIOUR1
Seborrhoeic dermatitis1
SCAPULA FRACTURE1
Rubber sensitivity1
Right ventricular systolic pressure increased1
Rhonchi1
RHINITIS ALLERGIC1
Rhinitis1
RHEUMATOID ARTHRITIS1
RETROPERITONEAL HAEMATOMA1
RETRACTED NIPPLE1
Retinal detachment1
RESTLESS LEGS SYNDROME1
Respiratory tract congestion1
Respiratory acidosis1
RESIDUAL URINE VOLUME1
Renal tubular necrosis1
Renal pain1
RENAL INFARCT1
RENAL COLIC1
REFLUX GASTRITIS1
RED BLOOD CELLS URINE POSITIVE1
Red blood cell count increased1
Red blood cell count abnormal1
RECTAL TENESMUS1
Rectal discharge1
Reaction to drug excipients1
Rash pustular1
RADIOISOTOPE SCAN1
PYRAMIDAL TRACT SYNDROME1
Pus in stool1
PURULENT DISCHARGE1
PUPILLARY REFLEX IMPAIRED1
Pulse waveform abnormal1
PULSE ABNORMAL1
PULMONARY VALVE INCOMPETENCE1
Pulmonary thrombosis1
Pulmonary mass1
Pulmonary haemorrhage1
PULMONARY FUNCTION CHALLENGE TEST ABNORMAL1
Pubis fracture1
PSYCHOTIC DISORDER DUE TO A GENERAL MEDICAL CONDITION1
PSYCHOTHERAPY1
PSYCHOSEXUAL DISORDER1
Psychomotor skills impaired1
Psychomotor seizures1
PSYCHOGENIC PAIN DISORDER1
PSYCHIATRIC DECOMPENSATION1
PSEUDARTHROSIS1
PROTHROMBIN TIME RATIO DECREASED1
PROTEINURIA1
PROTEIN URINE PRESENT1
Protein total increased1
Protein total abnormal1
PROSTATIC OBSTRUCTION1
PROSTATIC MASS1
Prostate infection1
Prostate cancer metastatic1
Prosopagnosia1
PROGESTERONE RECEPTOR ASSAY POSITIVE1
Product taste abnormal1
Product size issue1
Product prescribing issue1
Product monitoring error1
Product lot number issue1
Product label counterfeit1
Product dispensing error1
Product difficult to swallow1
Product design issue1
Product confusion1
Product complaint1
Product communication issue1
Procedural haemorrhage1
Prinzmetal angina1
Pregnancy test positive1
POVERTY OF SPEECH1
Postoperative wound infection1
Postoperative wound complication1
Postoperative delirium1
Posterior reversible encephalopathy syndrome1
POST-TRAUMATIC EPILEPSY1
POST PROCEDURAL PULMONARY EMBOLISM1
POST PROCEDURAL HYPOTHYROIDISM1
POSITIVE ROMBERGISM1
Poor venous access1
Poor peripheral circulation1
POLYURIA1
POLYPECTOMY1
POLYMORPHIC LIGHT ERUPTION1
Polycythaemia1
PO2 decreased1
Pneumothorax1
Pneumonia staphylococcal1
Pneumonia bacterial1
Pneumocephalus1
PLEURISY1
PLEURAL FIBROSIS1
PLEURAL DISORDER1
PLATELET PRODUCTION DECREASED1
Plasmacytoma1
PHOBIA1
PHARYNGOLARYNGEAL PAIN1
PHARYNGEAL ULCERATION1
Pharyngeal disorder1
Phantom pain1
PETECHIAE1
PERTUSSIS1
Pernicious anaemia1
PERIVASCULAR DERMATITIS1
Peritonitis1
Peritoneal hernia1
Peripheral venous disease1
PERIPHERAL REVASCULARISATION1
Peripheral ischaemia1
Periorbital haematoma1
PERICARDITIS1
PERICARDIAL EFFUSION1
Performance status decreased1
PERFORATED ULCER1
PERCUTANEOUS CORONARY INTERVENTION1
Peptic ulcer1
Penile infection1
Pelvic pain1
Pelvic cyst1
PCO2 increased1
Patient-device incompatibility1
Pathological fracture1
Parkinsonian crisis1
Parkinson's disease psychosis1
PARASOMNIA1
PARANEOPLASTIC SYNDROME1
PANNICULITIS1
Pancreatolithiasis1
PANCREATITIS HAEMORRHAGIC1
Pancreatitis chronic1
Pancreatic steatosis1
PANCREATIC ENZYMES INCREASED1
Pancreatic disorder1
Pancreatic carcinoma metastatic1
Palatal oedema1
PAIN MANAGEMENT1
PAIN IN JAW1
Packaging design issue1
Oxygen consumption decreased1
Ovarian cancer1
Osteopenia1
OSTEONECROSIS1
Osteitis deformans1
OROPHARYNGEAL PAIN1
ORGASM ABNORMAL1
Oral infection1
Oral fungal infection1
Oral discharge1
ORAL CANDIDIASIS1
Oral administration complication1
OPTIC DISC HAEMORRHAGE1
OPISTHOTONUS1
Open fracture1
ONCOLOGIC COMPLICATION1
OESTROGEN RECEPTOR ASSAY POSITIVE1
OESOPHAGITIS HAEMORRHAGIC1
OESOPHAGEAL VARICES HAEMORRHAGE1
Oesophageal rupture1
OESOPHAGEAL PERFORATION1
OESOPHAGEAL OBSTRUCTION1
OESOPHAGEAL FOOD IMPACTION1
OESOPHAGEAL DISORDER1
Oesophageal carcinoma recurrent1
OESOPHAGEAL CARCINOMA1
Oesophageal achalasia1
OCULAR ICTERUS1
Ocular hyperaemia1
OBSTRUCTIVE UROPATHY1
OBSTRUCTIVE AIRWAYS DISORDER1
Obsessive thoughts1
Nutritional condition abnormal1
NUCHAL RIGIDITY1
Normocytic anaemia1
NORMOCHROMIC NORMOCYTIC ANAEMIA1
Normochromic anaemia1
NORMAL TENSION GLAUCOMA1
Nonspecific reaction1
Non-Hodgkin's lymphoma1
Non-24-hour sleep-wake disorder1
Nocturnal fear1
NIKOLSKY'S SIGN1
Neurosyphilis1
NEUROSURGERY1
Neuropsychiatric lupus1
NEUROPATHY PERIPHERAL1
Neuromuscular blockade1
NEURODERMATITIS1
Neuralgia1
Nephrotic syndrome1
NEPHROSTOMY1
NEPHROPATHY TOXIC1
Nephropathy1
NEPHROGENIC ANAEMIA1
NEPHRITIS INTERSTITIAL1
NEPHRITIS1
Neoplasm prostate1
Neck mass1
NASAL NEOPLASM1
Nasal injury1
Nail discolouration1
MYXOEDEMA1
Myositis1
MYOCARDITIS1
Myocardial rupture1
Myocardial necrosis marker increased1
Myocardial necrosis1
MYASTHENIC SYNDROME1
MYASTHENIA GRAVIS1
Musculoskeletal disorder1
MUSCLE RUPTURE1
MUSCLE HAEMORRHAGE1
MUSCLE CRAMP1
MULTIPLE SYSTEM ATROPHY1
MUCOSAL EROSION1
MUCOCUTANEOUS RASH1
MOUTH ULCERATION1
MOUTH HAEMORRHAGE1
Motion sickness1
MORGANELLA INFECTION1
Monoparesis1
MIXED LIVER INJURY1
Mixed dementia1
MITRAL VALVE DISEASE1
Miliaria1
MICTURITION FREQUENCY DECREASED1
MICROCYTIC ANAEMIA1
Microangiopathy1
Metastatic uterine cancer1
Metastases to ovary1
Metastases to kidney1
METASTASES TO BONE1
METABOLIC FUNCTION TEST1
METABOLIC DISORDER1
MENTAL DISORDER DUE TO A GENERAL MEDICAL CONDITION1
MENINGITIS VIRAL1
MENINGITIS1
MENIERE'S DISEASE1
Melanocytic naevus1
Medical device site irritation1
Medical device site injury1
MEDICAL DEVICE COMPLICATION1
Mechanical ileus1
Mean platelet volume increased1
MEAN CELL VOLUME ABNORMAL1
MEAN CELL HAEMOGLOBIN DECREASED1
Maternal exposure during pregnancy1
Malignant palate neoplasm1
Malignant melanoma1
MALIGNANT HYPERTENSION1
MALABSORPTION1
Macule1
LYMPHOPENIA1
LYMPHOCYTIC INFILTRATION1
LYMPHOCYTE PERCENTAGE DECREASED1
Lymphocyte count increased1
LYMPHADENOPATHY MEDIASTINAL1
Lung perforation1
Lung opacity1
Lung infection pseudomonal1
Lumbar puncture1
Lower respiratory tract inflammation1
Lower respiratory tract infection bacterial1
LOW DENSITY LIPOPROTEIN INCREASED1
Low density lipoprotein decreased1
Locomotive syndrome1
Locked-in syndrome1
LIVIDITY1
LIP INJURY1
LIFE SUPPORT1
LIDDLE'S SYNDROME1
Leukoencephalopathy1
LEFT VENTRICULAR FAILURE1
Left atrial dilatation1
Learning disorder1
Laryngitis1
Laryngeal disorder1
LARGE INTESTINE CARCINOMA1
LARGE INTESTINAL OBSTRUCTION1
Language disorder1
Lactic acidosis1
Labelled drug-disease interaction medication error1
Kyphosis1
Korsakoff's syndrome1
KNEE ARTHROPLASTY1
Klebsiella sepsis1
Ketoacidosis1
JUDGEMENT IMPAIRED1
JOINT STIFFNESS1
JOINT EFFUSION1
JOINT ARTHROPLASTY1
Jaw fracture1
Irregular sleep wake rhythm disorder1
Iron deficiency anaemia1
Iron deficiency1
IRON BINDING CAPACITY TOTAL DECREASED1
INTRAOCULAR PRESSURE TEST ABNORMAL1
Intracranial haematoma1
Intracranial aneurysm1
INTRA-ABDOMINAL HAEMORRHAGE1
INTESTINAL MASS1
INTESTINAL DILATATION1
INTESTINAL ANGINA1
INTERVERTEBRAL DISC OPERATION1
Intervertebral disc degeneration1
INTERNATIONAL NORMALISED RATIO DECREASED1
Intermittent claudication1
Intercepted product dispensing error1
Intentional removal of drug delivery system by patient1
Intentional medical device removal by patient1
Intellectual disability1
Inner ear disorder1
INJURY ASPHYXIATION1
Inflammatory carcinoma of the breast1
Infectious pleural effusion1
INFECTIOUS PERITONITIS1
INDURATION1
INCREASED UPPER AIRWAY SECRETION1
INCREASED TENDENCY TO BRUISE1
Incorrect product storage1
Incorrect dosage administered1
INAPPROPRIATE AFFECT1
Inadequate diet1
IMPAIRED HEALING1
IMPAIRED GASTRIC EMPTYING1
IMPAIRED DRIVING ABILITY1
Immunodeficiency1
Immune system disorder1
ILLOGICAL THINKING1
IIIRD NERVE PARALYSIS1
Hypovitaminosis1
Hypoventilation1
HYPOPROTEINAEMIA1
HYPOGLYCAEMIC COMA1
Hypervolaemia1
HYPERTROPHIC CARDIOMYOPATHY1
HYPERTENSIVE NEPHROPATHY1
Hypertensive heart disease1
HYPERTENSIVE CARDIOMYOPATHY1
Hypersplenism1
HYPERPYREXIA1
HYPERPLASIA1
Hyperosmolar state1
Hyperlipidaemia1
HYPERLIPASAEMIA1
HYPERCHLORAEMIA1
Hyperbilirubinaemia1
HYPERADRENALISM1
HYDROTHORAX1
Hydrophobia1
HYDRONEPHROSIS1
Hyaluronic acid increased1
HIP SURGERY1
HIGH DENSITY LIPOPROTEIN DECREASED1
HERPES VIRUS INFECTION1
Herpes simplex meningoencephalitis1
Hernia pain1
HERNIA OBSTRUCTIVE1
HEPATITIS TOXIC1
HEPATITIS FULMINANT1
HEPATITIS A1
HEPATIC NEOPLASM MALIGNANT NON-RESECTABLE1
HEPATIC NEOPLASM MALIGNANT1
HEPATIC LESION1
HEPATIC FIBROSIS1
Hepatic cancer metastatic1
HEPATIC CALCIFICATION1
HENOCH-SCHONLEIN PURPURA1
HEMICEPHALALGIA1
HEMIANOPIA HOMONYMOUS1
Helplessness1
Heat stroke1
HEART SOUNDS ABNORMAL1
Heart rate abnormal1
Head banging1
HALLUCINATION, TACTILE1
Hallucination, olfactory1
Haemothorax1
HAEMORRHOID OPERATION1
HAEMORRHAGIC ASCITES1
Haemorrhagic anaemia1
HAEMOGLOBIN INCREASED1
Haematoma infection1
HAEMATOMA EVACUATION1
GYNAECOMASTIA1
GROWTH OF EYELASHES1
Grip strength decreased1
GRANULOMA1
Gout1
Glucose-6-phosphate dehydrogenase deficiency1
GLOSSODYNIA1
Glioblastoma1
GLASGOW COMA SCALE ABNORMAL1
GLARE1
Gingival pain1
GENITOURINARY TRACT NEOPLASM1
Genitourinary symptom1
General physical condition decreased1
GASTROINTESTINAL ULCER1
Gastrointestinal motility disorder1
GASTROINTESTINAL ISCHAEMIA1
GASTROINTESTINAL HYPERMOTILITY1
Gastroenteritis norovirus1
GASTROENTERITIS CLOSTRIDIAL1
GASTRODUODENITIS1
GASTRITIS HAEMORRHAGIC1
Gastritis atrophic1
Gastric ulcer perforation1
GASTRIC LAVAGE1
GASTRIC HYPERMOTILITY1
Gastric fistula1
GASTRIC ADENOMA1
Gangrene1
Gallbladder hypofunction1
GAIT DEVIATION1
Fungal infection1
FULL BLOOD COUNT ABNORMAL1
Frostbite1
FRACTURED COCCYX1
Fracture pain1
FORMICATION1
FOOD CRAVING1
FOOD AVERSION1
FLIGHT OF IDEAS1
Fixed drug eruption1
FIBROSIS1
Fibroma1
FIBRIN DEGRADATION PRODUCTS INCREASED1
Femoral hernia, obstructive1
Female genital tract fistula1
FEELINGS OF WORTHLESSNESS1
Feeling of despair1
FEBRILE NEUTROPENIA1
False positive investigation result1
Faecal volume increased1
FACIAL PARESIS1
Facial neuralgia1
Facial nerve disorder1
Eyelid irritation1
Eyelid disorder1
EYEBALL RUPTURE1
Eye contusion1
Extremity necrosis1
EXTRADURAL HAEMATOMA1
Extra dose administered1
Exposure during pregnancy1
EUTHANASIA1
Escherichia test positive1
Eructation1
EROSIVE DUODENITIS1
EPIDERMOLYSIS1
EPIDERMAL GROWTH FACTOR RECEPTOR INCREASED1
Ephelides1
EOSINOPHILIC PNEUMONIA1
Enuresis1
ENTEROCOLITIS1
Enterococcal infection1
Energy increased1
ENDOSCOPY UPPER GASTROINTESTINAL TRACT1
ENDOSCOPY1
ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY1
EMPYEMA1
EMOTIONAL DISTRESS1
EMBOLISM ARTERIAL1
Embolic stroke1
Electrocardiogram T wave inversion1
Electrocardiogram T wave abnormal1
Electrocardiogram ST-T change1
Electrocardiogram ST segment elevation1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION1
Electrocardiogram ST segment abnormal1
Electrocardiogram repolarisation abnormality1
ELECTROCARDIOGRAM QT CORRECTED INTERVAL PROLONGED1
ELECTROCARDIOGRAM PQ INTERVAL PROLONGED1
ELECTROCARDIOGRAM CHANGE1
EFFUSION1
ECZEMA WEEPING1
ECTROPION1
EAR PAIN1
Ear haemorrhage1
DYSPNOEA AT REST1
DYSPHASIA1
Dyslipidaemia1
Dyschezia1
Duodenal ulcer perforation1
Duodenal stenosis1
Duodenal papillitis1
Dry throat1
Drug tolerance1
Drug resistance1
DRUG LEVEL BELOW THERAPEUTIC1
Drug label confusion1
Drug effect delayed1
Drug abuse1
Dropped head syndrome1
DROP ATTACKS1
DIVERTICULUM GASTRIC1
Dislocation of vertebra1
DiGeorge's syndrome1
DIFFICULTY IN WALKING1
Differential white blood cell count abnormal1
DIABETIC NEPHROPATHY1
Diabetic hyperglycaemic coma1
DIABETES INSIPIDUS1
DEVICE RELATED INFECTION1
Device leakage1
DERMATITIS ATOPIC1
DEPRESSIVE SYMPTOM1
Depression suicidal1
Depersonalisation/derealisation disorder1
Dependent personality disorder1
Dental caries1
DELUSIONAL DISORDER, PERSECUTORY TYPE1
DELUSION OF GRANDEUR1
DELIRIUM TREMENS1
Deformity1
DEFAECATION URGENCY1
DANDRUFF1
CYTOMEGALOVIRUS ANTIBODY POSITIVE1
CYSTOSTOMY1
CYSTOSCOPY1
CYSTITIS KLEBSIELLA1
CUTIS LAXA1
Cutaneous vasculitis1
CULTURE URINE POSITIVE1
CSF PROTEIN INCREASED1
CRYPTOGENIC CIRRHOSIS1
CROHN'S DISEASE1
Creutzfeldt-Jakob disease1
CRANIOTOMY1
Cranial nerve paralysis1
Cow's milk intolerance1
Cough decreased1
Costochondritis1
Coronavirus infection1
Coronary artery insufficiency1
CORONARY ARTERIAL STENT INSERTION1
CORONARY ANGIOPLASTY1
Conversion disorder1
Consciousness fluctuating1
CONJUNCTIVAL PALLOR1
CONJUNCTIVAL HYPERAEMIA1
CONJUNCTIVAL HAEMORRHAGE1
Confabulation1
Complication associated with device1
COMPLEX PARTIAL SEIZURES1
COLOSTOMY1
COLORECTAL CANCER METASTATIC1
COLONOSCOPY ABNORMAL1
COLONIC PSEUDO-OBSTRUCTION1
COLONIC POLYP1
COLON CANCER RECURRENT1
COLITIS COLLAGENOUS1
COGWHEEL RIGIDITY1
Coating in mouth1
COAGULATION TEST ABNORMAL1
COAGULATION FACTOR DECREASED1
CLUSTER HEADACHE1
Clumsiness1
Clostridium difficile infection1
CLOSTRIDIUM DIFFICILE COLITIS1
Clonic convulsion1
Chronic respiratory failure1
Chronic myeloid leukaemia1
Chronic gastritis1
Chorea1
CHOLECYSTITIS INFECTIVE1
CHOLECYSTITIS CHRONIC1
Chemical injury1
Cervix carcinoma1
Cervicobrachial syndrome1
CEREBRAL SMALL VESSEL ISCHAEMIC DISEASE1
Cerebral hypoperfusion1
CEREBRAL HAEMATOMA1
Cerebral cyst1
Cerebral calcification1
CEREBRAL ARTERY STENOSIS1
CEREBRAL ARTERIOSCLEROSIS1
CEREBRAL AMYLOID ANGIOPATHY1
CEREBELLAR SYNDROME1
CEREBELLAR INFARCTION1
Cerebellar ataxia1
Central nervous system infection1
Cell marker increased1
CELL DEATH1
CATHETERISATION CARDIAC1
Catheter site haemorrhage1
CAROTID SINUS SYNDROME1
CAROTID ARTERY STENOSIS1
Carotid artery disease1
CAROTID ARTERY ATHEROMA1
Carotid artery aneurysm1
CARDIOGENIC SHOCK1
CARDIO-RESPIRATORY DISTRESS1
CARDIAC VALVE SCLEROSIS1
CARDIAC TAMPONADE1
CARDIAC PACEMAKER MALFUNCTION1
CARDIAC OPERATION1
CARDIAC MONITORING1
CARDIAC MASSAGE1
Cardiac index abnormal1
CARDIAC FLUTTER1
CARDIAC ELECTROPHYSIOLOGIC STUDY ABNORMAL1
Cardiac dysfunction1
CARDIAC DEATH1
Cardiac asthma1
CARBON DIOXIDE DECREASED1
CANDIDIASIS1
Candida test positive1
Candida pneumonia1
Camptocormia1
Calculus bladder1
BURNS SECOND DEGREE1
Bronchopulmonary aspergillosis1
Bronchitis chronic1
BRONCHIAL CARCINOMA1
BREAST OPERATION1
BREAST OEDEMA1
BREAST NEOPLASM1
BREAST ENLARGEMENT1
BREAST CANCER RECURRENT1
Breast cancer metastatic1
BRAIN STEM INFARCTION1
BRAIN SCAN ABNORMAL1
BRAIN HYPOXIA1
Brain death1
Brain contusion1
BRAIN COMPRESSION1
BRAIN CANCER METASTATIC1
BRADYPNOEA1
Bowen's disease1
Bone sarcoma1
BONE NEOPLASM MALIGNANT1
Bone neoplasm1
Bone marrow granuloma1
Bone density decreased1
BODY TEMPERATURE FLUCTUATION1
Body surface area decreased1
Body height abnormal1
Body fat disorder1
Blood uric acid decreased1
BLOOD UREA DECREASED1
Blood urea abnormal1
BLOOD THYROID STIMULATING HORMONE DECREASED1
BLOOD TEST ABNORMAL1
BLOOD SODIUM ABNORMAL1
Blood prolactin increased1
Blood pressure immeasurable1
Blood phosphorus decreased1
BLOOD OSMOLARITY INCREASED1
BLOOD OSMOLARITY DECREASED1
BLOOD IRON DECREASED1
BLOOD IMMUNOGLOBULIN A INCREASED1
BLOOD ELECTROLYTES ABNORMAL1
Blood disorder1
Blood creatinine abnormal1
Blood cholinesterase increased1
Blood cholesterol1
BLOOD CHLORIDE INCREASED1
Blood catecholamines increased1
Blood calcium increased1
BLOOD BILIRUBIN DECREASED1
Blood bicarbonate increased1
Blood beta-D-glucan increased1
Blood albumin increased1
Blister infected1
Blepharospasm1
Blepharitis1
Bleeding varicose vein1
BLADDER SPHINCTER ATONY1
BLADDER MASS1
BLADDER CATHETER PERMANENT1
BLADDER ADENOCARCINOMA STAGE UNSPECIFIED1
BIOPSY LIVER ABNORMAL1
BILIRUBIN CONJUGATED INCREASED1
BILIARY DYSKINESIA1
BILE OUTPUT DECREASED1
Bile duct stone1
Bile duct stenosis1
Beta-N-acetyl-D-glucosaminidase1
BETA 2 MICROGLOBULIN INCREASED1
BENIGN NEOPLASM1
Belligerence1
BASOPHIL PERCENTAGE DECREASED1
BAND NEUTROPHIL PERCENTAGE INCREASED1
BALLISMUS1
Bacterial test positive1
Back disorder1
B-cell lymphoma1
Axillary pain1
AV DISSOCIATION1
AUTOIMMUNE HEPATITIS1
Atypical mycobacterial pneumonia1
ATTENTION DEFICIT/HYPERACTIVITY DISORDER1
Atrophic glossitis1
ATRIOVENTRICULAR EXTRASYSTOLES1
Atrioventricular conduction time shortened1
ATRIAL TACHYCARDIA1
Atrial enlargement1
Athetosis1
ATHEROSCLEROSIS1
Asthmatic crisis1
Aspergillus infection1
ASPARTATE AMINOTRANSFERASE DECREASED1
ARTERIOSCLEROSIS OBLITERANS1
ARTERIAL STENT INSERTION1
ARTERIAL INJURY1
Arterial disorder1
ARRHYTHMIA SUPRAVENTRICULAR1
APTYALISM1
Application site wound1
APPLICATION SITE WARMTH1
Application site ulcer1
Application site telangiectasia1
Application site streaking1
Application site plaque1
APPLICATION SITE PAPULES1
Application site hypoaesthesia1
Application site dryness1
APPLICATION SITE DISCHARGE1
APPARENT LIFE THREATENING EVENT1
Aphonia1
AORTIC STENOSIS1
AORTIC DISSECTION1
AORTIC DILATATION1
AORTIC ARTERIOSCLEROSIS1
AORTIC ANEURYSM REPAIR1
ANXIETY DISORDER1
Antipsychotic drug level above therapeutic1
Antiphospholipid syndrome1
ANTICONVULSANT DRUG LEVEL INCREASED1
ANTIBODY TEST ABNORMAL1
ANOXIC ENCEPHALOPATHY1
Anorexia nervosa1
Ankle fracture1
Animal bite1
ANGIONEUROTIC OEDEMA1
ANGINA UNSTABLE1
Aneurysm ruptured1
ANEURYSM1
Anaphylactoid reaction1
ANAL SPHINCTER ATONY1
ANAL ABSCESS1
Anaesthetic complication1
Anaemia megaloblastic1
Anaemia haemolytic autoimmune1
AMYOTROPHIC LATERAL SCLEROSIS1
Amyloidosis1
Amylase increased1
Amino acid level increased1
AMAUROSIS1
Allergy to arthropod sting1
Albumin globulin ratio decreased1
AGRANULOCYTOSIS1
Age-related macular degeneration1
AFFECTIVE DISORDER1
ADVERSE EVENT1
ADRENAL MASS1
ADRENAL ADENOMA1
Administration site pain1
ACUTE VESTIBULAR SYNDROME1
Acute myeloid leukaemia1
ACUTE ABDOMEN1
ACTIVATED PARTIAL THROMBOPLASTIN TIME SHORTENED1
ACTIVATED PARTIAL THROMBOPLASTIN TIME1
Accidental exposure to product by child1
ACCIDENTAL DRUG INTAKE BY CHILD1
ABSCESS DRAINAGE1
Abscess1
Abnormal loss of weight1
ABDOMINAL WALL HAEMORRHAGE1
Abdominal wall haematoma1
ABDOMINAL SEPSIS1
ABDOMINAL NEOPLASM1
ABDOMINAL MASS1
ABDOMINAL INJURY1
Abdominal infection1
Abdominal hernia1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P06276 14.3 Cholinesterase CHLE_HUMAN
P22303 37 Acetylcholinesterase ACES_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 1000 mg/kg



External links:

ChEBML: CHEMBL636
DrugBank: DB00989