posaconazole


EMA33



General information:


Withdrawn ID: EMA33
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): J02AC04
Molecular Formula: C37H42F2N8O4
Molweight: 700.777



Withdrawal information:


Withdrawn due to drug safety reasons:No



Side-effects:

Total reported cases (submitted by medical professionals) with posaconazole as primary suspect: 1415


Reported final outcomes:
Hospitalization (initial or prolonged): 435
Death: 325
Life-Threatening condition: 103
Disability: 29
Intervention required to prevent permanent impairment/damage: 2
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
DRUG INEFFECTIVE175
Product use in unapproved indication127
Off label use108
DRUG INTERACTION100
DEATH93
PYREXIA51
Drug level below therapeutic47
DIARRHOEA47
Adverse event45
HYPOKALAEMIA44
Product use issue40
NAUSEA40
FUNGAL INFECTION40
FEBRILE NEUTROPENIA38
No adverse event37
PNEUMONIA36
VOMITING33
BRONCHOPULMONARY ASPERGILLOSIS31
SEPSIS30
HYPERTENSION30
Antibiotic level below therapeutic29
CONDITION AGGRAVATED28
RASH27
ELECTROCARDIOGRAM QT PROLONGED27
RESPIRATORY FAILURE26
HEPATOTOXICITY26
Hepatocellular injury26
NEUTROPENIA25
THROMBOCYTOPENIA24
RENAL FAILURE24
CHOLESTASIS24
ASPARTATE AMINOTRANSFERASE INCREASED21
Acute kidney injury21
INFECTION20
DISEASE PROGRESSION20
SYSTEMIC MYCOSIS19
CARDIAC ARREST19
Aspergillus infection19
SEPTIC SHOCK18
PANCYTOPENIA18
HYPONATRAEMIA18
DYSPNOEA18
ALANINE AMINOTRANSFERASE INCREASED18
ABDOMINAL PAIN18
OVERDOSE17
HEADACHE17
CONSTIPATION17
ACUTE MYELOID LEUKAEMIA17
Wrong technique in product usage process16
TREATMENT FAILURE16
PATHOGEN RESISTANCE16
LIVER FUNCTION TEST ABNORMAL16
CARDIAC FAILURE16
ASTHENIA16
TRANSAMINASES INCREASED15
PNEUMONIA FUNGAL15
NEUROPATHY PERIPHERAL15
GRAFT VERSUS HOST DISEASE15
GENERAL PHYSICAL HEALTH DETERIORATION15
FATIGUE15
HEPATIC ENZYME INCREASED14
PLEURAL EFFUSION13
MUCORMYCOSIS13
INCORRECT DOSE ADMINISTERED13
HAEMOGLOBIN DECREASED13
FUSARIUM INFECTION13
PLATELET COUNT DECREASED12
NEUROTOXICITY12
MULTI-ORGAN FAILURE12
HYPOMAGNESAEMIA12
Drug-induced liver injury12
DRUG LEVEL DECREASED12
DECREASED APPETITE12
COUGH12
CONVULSION12
BRADYCARDIA12
BLOOD ALKALINE PHOSPHATASE INCREASED12
ATRIAL FIBRILLATION12
ASPERGILLOSIS12
OEDEMA PERIPHERAL11
HYPOTENSION11
HYPERBILIRUBINAEMIA11
Drug dose omission11
VENTRICULAR TACHYCARDIA10
TOXICITY TO VARIOUS AGENTS10
TORSADE DE POINTES10
PRURITUS10
Product quality issue10
Pancreatitis acute10
HYPOPHOSPHATAEMIA10
HEPATIC FUNCTION ABNORMAL10
GASTROINTESTINAL HAEMORRHAGE10
Dysphagia10
DRUG INTOLERANCE10
DIZZINESS10
BLOOD BILIRUBIN INCREASED10
ANAEMIA10
TREMOR9
TOXIC SKIN ERUPTION9
SYSTEMIC CANDIDA9
RHABDOMYOLYSIS9
RENAL FAILURE ACUTE9
Product dose omission issue9
PAIN9
MUSCULAR WEAKNESS9
MALAISE9
LUNG INFILTRATION9
LEUKOPENIA9
LEUKAEMIA9
Incorrect route of product administration9
Inappropriate schedule of drug administration9
HEPATIC FAILURE9
GAMMA-GLUTAMYLTRANSFERASE INCREASED9
Epistaxis9
ENCEPHALOPATHY9
DRUG RESISTANCE9
DISEASE RECURRENCE9
CONFUSIONAL STATE9
CHEST PAIN9
ACUTE MYELOID LEUKAEMIA RECURRENT9
ZYGOMYCOSIS8
URTICARIA8
PULMONARY EMBOLISM8
Product administered to patient of inappropriate age8
PAIN IN EXTREMITY8
Myelodysplastic syndrome8
MYALGIA8
MALABSORPTION8
LUNG INFECTION8
INSOMNIA8
INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION8
HYPERKALAEMIA8
HALLUCINATION8
HAEMORRHAGE8
FACE OEDEMA8
Drug level increased8
Drug eruption8
Drug administered to patient of inappropriate age8
DEHYDRATION8
BLOOD CREATININE INCREASED8
VENTRICULAR FIBRILLATION7
TUMOUR LYSIS SYNDROME7
THERAPEUTIC RESPONSE DECREASED7
STEM CELL TRANSPLANT7
Rash maculo-papular7
PULMONARY OEDEMA7
POLYNEUROPATHY7
PARAESTHESIA7
NO THERAPEUTIC RESPONSE7
MYOCARDIAL INFARCTION7
LOSS OF CONSCIOUSNESS7
LIVER DISORDER7
INTERSTITIAL LUNG DISEASE7
ILEUS PARALYTIC7
ILEUS7
CHILLS7
CARDIAC FAILURE CONGESTIVE7
ACUTE GRAFT VERSUS HOST DISEASE IN SKIN7
ACUTE GRAFT VERSUS HOST DISEASE IN INTESTINE7
ABDOMINAL PAIN UPPER7
ABDOMINAL DISTENSION7
WHITE BLOOD CELL COUNT DECREASED6
STOMATITIS6
RENAL IMPAIRMENT6
PULMONARY MASS6
Pseudoaldosteronism6
Product deposit6
Neutrophil count decreased6
Multiple organ dysfunction syndrome6
MOUTH ULCERATION6
LYMPHADENOPATHY6
LONG QT SYNDROME6
Liver injury6
Incorrect drug dosage form administered6
Hepatic cytolysis6
HALLUCINATION, VISUAL6
HAEMOPTYSIS6
HAEMATURIA6
Gastrointestinal tube insertion6
GASTROINTESTINAL DISORDER6
FALL6
DRUG TOXICITY6
COMA6
CATARACT6
BLOOD POTASSIUM DECREASED6
BLOOD LACTATE DEHYDROGENASE INCREASED6
ARTHRALGIA6
ANXIETY6
ADRENAL INSUFFICIENCY6
WEIGHT DECREASED5
SINUS BRADYCARDIA5
Seizure5
Peripheral swelling5
PANCREATITIS5
ORAL HERPES5
MUSCULOSKELETAL PAIN5
MENTAL STATUS CHANGES5
MEDICATION ERROR5
MALIGNANT NEOPLASM PROGRESSION5
Liver function test increased5
LEUKAEMIA RECURRENT5
Jaundice5
Inappropriate schedule of product administration5
HYPERGLYCAEMIA5
Generalised tonic-clonic seizure5
Generalised oedema5
GAIT DISTURBANCE5
FLUID OVERLOAD5
Feeling abnormal5
ERYTHEMA5
Drug ineffective for unapproved indication5
Drug effective for unapproved indication5
Drug administration error5
Dermatitis exfoliative5
CYTOMEGALOVIRUS INFECTION5
CEREBRAL ASPERGILLOSIS5
CARDIO-RESPIRATORY ARREST5
BONE MARROW TRANSPLANT5
BONE MARROW FAILURE5
Bacterial infection5
Back pain5
ASCITES5
ARRHYTHMIA5
APLASIA5
ACUTE RESPIRATORY FAILURE5
ACUTE RESPIRATORY DISTRESS SYNDROME5
VISUAL IMPAIRMENT4
Ventricular arrhythmia4
TREATMENT NONCOMPLIANCE4
Thrombotic microangiopathy4
Tendonitis4
TACHYCARDIA4
STAPHYLOCOCCAL INFECTION4
SQUAMOUS CELL CARCINOMA4
SOMNOLENCE4
SINUSITIS4
Renal tubular disorder4
RED BLOOD CELL COUNT DECREASED4
PULMONARY HAEMORRHAGE4
PSEUDOMONAS INFECTION4
PRODUCTIVE COUGH4
POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME4
PNEUMONIA BACTERIAL4
Pericardial effusion4
PALPITATIONS4
NERVOUS SYSTEM DISORDER4
MUCOSAL INFLAMMATION4
LUNG NEOPLASM4
LETHARGY4
Labelled drug-drug interaction issue4
Incorrect product formulation administered4
HYPOCALCAEMIA4
HYPOAESTHESIA4
Hospitalisation4
Hospice care4
Hepatitis cholestatic4
HAEMATOCRIT DECREASED4
GINGIVAL BLEEDING4
FUNGAL SEPSIS4
Fungaemia4
Enterococcal bacteraemia4
ENCEPHALITIS4
Electrolyte imbalance4
DYSPEPSIA4
DYSGEUSIA4
DISSEMINATED INTRAVASCULAR COAGULATION4
Contraindicated product administered4
CHOLELITHIASIS4
Cholecystitis acute4
Cellulitis4
CELL DEATH4
CANDIDIASIS4
BRONCHITIS4
Blood uric acid decreased4
Blood sodium decreased4
BLOOD CULTURE POSITIVE4
BLOOD ALBUMIN DECREASED4
BILIRUBIN CONJUGATED INCREASED4
BACTERAEMIA4
Azotaemia4
AREFLEXIA4
Alopecia4
ACUTE GRAFT VERSUS HOST DISEASE IN LIVER4
WOUND INFECTION3
VISUAL DISTURBANCE3
VISION BLURRED3
URINARY TRACT INFECTION3
Underdose3
Tubulointerstitial nephritis3
TRANSPLANT3
Toxic epidermal necrolysis3
TOXIC ENCEPHALOPATHY3
Therapy responder3
Therapy cessation3
SYNCOPE3
Staphylococcal sepsis3
Squamous cell carcinoma of skin3
SKIN LESION3
SKIN EXFOLIATION3
SKIN DISORDER3
SHOCK3
SCEDOSPORIUM INFECTION3
RENAL DISORDER3
REFUSAL OF TREATMENT BY PATIENT3
RASH PRURITIC3
Rash morbilliform3
Rash erythematous3
PURPURA3
PULMONARY MYCOSIS3
PSYCHOTIC DISORDER3
PROTHROMBIN TIME PROLONGED3
PROTEINURIA3
PROTEIN TOTAL DECREASED3
Primary adrenal insufficiency3
Prescribed overdose3
PHOTOSENSITIVITY REACTION3
Peripheral sensory neuropathy3
PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME3
Oesophagitis3
OEDEMA3
Neutropenic colitis3
NEPHROPATHY TOXIC3
NEOPLASM MALIGNANT3
MYOSITIS3
MYOCLONUS3
MUSCLE ATROPHY3
METABOLIC ENCEPHALOPATHY3
METABOLIC ACIDOSIS3
MEMORY IMPAIRMENT3
MELAENA3
MALNUTRITION3
LABORATORY TEST ABNORMAL3
Labelled drug-drug interaction medication error3
INTESTINAL OBSTRUCTION3
INFLAMMATION3
Incorrect product storage3
Immunosuppressant drug level increased3
Hypoxia3
HYPOACUSIS3
HEPATOCELLULAR DAMAGE3
HEPATITIS ACUTE3
Hepatitis3
HEPATIC FIBROSIS3
HEART RATE INCREASED3
HAEMOLYTIC ANAEMIA3
GRAFT VERSUS HOST DISEASE IN SKIN3
Graft versus host disease in gastrointestinal tract3
GASTROINTESTINAL TOXICITY3
FLUID RETENTION3
Ejection fraction decreased3
Eczema3
Dysuria3
Dry mouth3
Drug reaction with eosinophilia and systemic symptoms3
Drug hypersensitivity3
Drug effect incomplete3
DISTURBANCE IN ATTENTION3
Differentiation syndrome3
DIALYSIS3
Cytopenia3
CYTOLYTIC HEPATITIS3
Conjunctival haemorrhage3
COLITIS3
COGNITIVE DISORDER3
Circumstance or information capable of leading to medication error3
CEREBRAL DISORDER3
CARDIOACTIVE DRUG LEVEL INCREASED3
CARDIAC DISORDER3
Candida infection3
C-reactive protein increased3
BRAIN OEDEMA3
Brain abscess3
Blood magnesium decreased3
Blood glucose increased3
BLOOD CHOLINESTERASE DECREASED3
Blood calcium decreased3
AXONAL NEUROPATHY3
Arthritis3
ARRHYTHMIA SUPRAVENTRICULAR3
ALTERED STATE OF CONSCIOUSNESS3
Agranulocytosis3
AGITATION3
ADVERSE DRUG REACTION3
ACUTE PULMONARY OEDEMA3
Acute myocardial infarction3
ACUTE LYMPHOCYTIC LEUKAEMIA RECURRENT3
ACUTE LYMPHOCYTIC LEUKAEMIA3
Accidental overdose3
ABASIA3
White blood cell count increased2
WEIGHT INCREASED2
VERTIGO2
Vasculitis2
UPPER GASTROINTESTINAL HAEMORRHAGE2
TRANSPLANT FAILURE2
Transient ischaemic attack2
Total bile acids increased2
TINNITUS2
THROMBOTIC THROMBOCYTOPENIC PURPURA2
Thrombosis2
Therapy non-responder2
THERAPEUTIC RESPONSE UNEXPECTED2
THERAPEUTIC PRODUCT INEFFECTIVE2
SWOLLEN TONGUE2
SUPRAVENTRICULAR EXTRASYSTOLES2
SUDDEN DEATH2
SUBDURAL HAEMORRHAGE2
STENOTROPHOMONAS INFECTION2
Splenic infection fungal2
SINUS TACHYCARDIA2
Secondary hypertension2
Secondary adrenocortical insufficiency2
Rhinorrhoea2
Rhinocerebral mucormycosis2
Retinal vein occlusion2
Retching2
RESPIRATORY TRACT INFECTION FUNGAL2
RESPIRATORY SYNCYTIAL VIRUS INFECTION2
RESPIRATORY DISORDER2
RESPIRATORY ARREST2
Renal artery thrombosis2
Red blood cell sedimentation rate increased2
Red blood cell schistocytes present2
RECTAL HAEMORRHAGE2
RASH PAPULAR2
PULMONARY HYPERTENSION2
Pulmonary arterial hypertension2
Pulmonary alveolar haemorrhage2
Product taste abnormal2
Product supply issue2
Product prescribing issue2
Product prescribing error2
Product dose omission2
Product dosage form confusion2
Product distribution issue2
PRESYNCOPE2
POST PROCEDURAL COMPLICATION2
Polyuria2
Pollakiuria2
PNEUMONITIS2
Platelet transfusion2
Platelet count increased2
PHARYNGITIS2
Petechiae2
PERONEAL NERVE PALSY2
PERIORBITAL OEDEMA2
PCO2 DECREASED2
Parainfluenzae virus infection2
PAPILLOEDEMA2
Pain in jaw2
Oxygen saturation decreased2
Osteoporosis2
Organ failure2
Optic neuropathy2
NODAL ARRHYTHMIA2
Nightmare2
NEUTROPHIL PERCENTAGE DECREASED2
Neuralgia2
NEPHROTIC SYNDROME2
Nasopharyngitis2
Myelosuppression2
MUSCLE DISORDER2
MITRAL VALVE INCOMPETENCE2
METABOLIC DISORDER2
Mental impairment2
Mental disorder2
MEGACOLON2
LYMPHOMA2
Lymphadenopathy mediastinal2
Lung opacity2
Lung disorder2
LUNG CONSOLIDATION2
Localised infection2
LIVER ABSCESS2
Lip squamous cell carcinoma2
LEFT VENTRICULAR HYPERTROPHY2
Left ventricular dysfunction2
Lactic acidosis2
Laboratory test interference2
Klebsiella sepsis2
KLEBSIELLA INFECTION2
Ischaemic stroke2
INTESTINAL PERFORATION2
Incorrect storage of drug2
Incorrect route of drug administration2
Incorrect product administration duration2
Immunosuppression2
Ill-defined disorder2
HYPOVOLAEMIC SHOCK2
Hypothermia2
HYPOPHAGIA2
HYPERTRIGLYCERIDAEMIA2
Hypertensive crisis2
Hypernatraemia2
HYPERCALCAEMIA2
Hyperaldosteronism2
Hip fracture2
Herpes virus infection2
Herpes simplex2
Hepatitis fulminant2
HEPATIC LESION2
Hepatic infection fungal2
Hepatic enzyme abnormal2
HEPATIC ENCEPHALOPATHY2
HEMIPARESIS2
Hearing impaired2
Haemorrhoids2
HAEMOLYTIC URAEMIC SYNDROME2
HAEMODIALYSIS2
Haemochromatosis2
GUILLAIN-BARRE SYNDROME2
GRAND MAL CONVULSION2
GRAFT VERSUS HOST DISEASE IN LUNG2
Graft versus host disease in liver2
Globulins decreased2
GLAUCOMA2
GASTROENTERITIS2
FOOD INTOLERANCE2
Febrile infection2
Febrile bone marrow aplasia2
FAECALOMA2
EYE DISORDER2
Expired product administered2
EXOPHTHALMOS2
Escherichia bacteraemia2
EPSTEIN-BARR VIRUS INFECTION2
Epstein-Barr viraemia2
EPILEPSY2
ENTEROCOCCAL INFECTION2
ENTEROBACTER INFECTION2
Endocarditis2
ELECTROENCEPHALOGRAM ABNORMAL2
DYSSTASIA2
DYSKINESIA2
DRY SKIN2
Dry eye2
Drug prescribing error2
DRUG LEVEL ABOVE THERAPEUTIC2
Diverticulitis2
DISORIENTATION2
DIPLOPIA2
DIFFUSE ALVEOLAR DAMAGE2
DIABETES MELLITUS2
Device occlusion2
Dermatitis2
DEPRESSED LEVEL OF CONSCIOUSNESS2
Delirium2
DEAFNESS NEUROSENSORY2
CYSTITIS2
CYANOSIS2
COVID-192
CONGESTIVE CARDIOMYOPATHY2
Clostridium difficile colitis2
Chronic kidney disease2
Chest discomfort2
Cheilitis2
CEREBRAL FUNGAL INFECTION2
Central venous catheterisation2
CATATONIA2
CARDIOTOXICITY2
CAPILLARY LEAK SYNDROME2
Bone pain2
BONE DISORDER2
Blood pressure increased2
BLOOD PRESSURE DECREASED2
Blood phosphorus decreased2
Blood immunoglobulin G decreased2
Blood creatinine decreased2
Blood creatine phosphokinase decreased2
Blood bilirubin unconjugated increased2
BLINDNESS2
BK VIRUS INFECTION2
Bicytopenia2
Balance disorder2
ATRIOVENTRICULAR BLOCK SECOND DEGREE2
ASPIRATION2
Aplastic anaemia2
Anuria2
ANGIOEDEMA2
Alkalosis2
Acute monocytic leukaemia2
ACUTE HEPATIC FAILURE2
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS2
Acquired apparent mineralocorticoid excess2
Acne2
Abdominal discomfort2
Wrong technique in drug usage process1
WRONG DRUG ADMINISTERED1
Wrong dose1
Weight gain poor1
Water intoxication1
VITAMIN D DEFICIENCY1
Vitamin A deficiency1
VISUAL ACUITY REDUCED1
Viral infection1
VIIth nerve paralysis1
VENTRICULAR HYPERTROPHY1
VENTRICULAR FLUTTER1
VENTRICULAR EXTRASYSTOLES1
Venoocclusive disease1
Venipuncture1
VENA CAVA THROMBOSIS1
VASOGENIC CEREBRAL OEDEMA1
Varicella zoster virus infection1
Vaginal haemorrhage1
Urinary tract infection enterococcal1
Urinary tract disorder1
Urinary retention1
URINARY BLADDER HAEMORRHAGE1
Upper respiratory tract congestion1
Unresponsive to stimuli1
UNEVALUABLE EVENT1
Typhoid fever1
Type 1 diabetes mellitus1
Tumour associated fever1
Tuberculosis of central nervous system1
Tricuspid valve incompetence1
TRICHOSPORON INFECTION1
Transplantation complication1
Transfusion1
Transformation to acute myeloid leukaemia1
Transcription medication error1
Tracheostomy1
TOXOPLASMOSIS1
Tooth discolouration1
Tonsillitis1
Tongue ulceration1
TONGUE DISORDER1
TONGUE DISCOLOURATION1
Tinea infection1
Thrombocytosis1
Thrombocytopenic purpura1
THROAT IRRITATION1
Thinking abnormal1
THERAPEUTIC AGENT TOXICITY1
Taste disorder1
Tachypnoea1
TACHYARRHYTHMIA1
Systemic lupus erythematosus1
Symmetrical drug-related intertriginous and flexural exanthema1
SWELLING FACE1
Swelling1
Surgery1
SUPRAVENTRICULAR TACHYCARDIA1
SUNBURN1
Subdural haematoma1
SUBCUTANEOUS NODULE1
Subcutaneous emphysema1
Subacute cutaneous lupus erythematosus1
STUPOR1
Streptococcal bacteraemia1
STOMACH DISCOMFORT1
Stevens-Johnson syndrome1
Steroid diabetes1
STENOTROPHOMONAS SEPSIS1
STATUS EPILEPTICUS1
Sputum discoloured1
SPLENOMEGALY1
Splenic rupture1
Splenic haemorrhage1
Splenic abscess1
Speech disorder1
Soft tissue inflammation1
SOFT TISSUE DISORDER1
Small intestinal obstruction1
Small for dates baby1
Skin reaction1
Skin necrosis1
Skin mass1
Skin injury1
Skin burning sensation1
Skin atrophy1
SJS-TEN overlap1
Sinusitis fungal1
SINUSITIS BACTERIAL1
SINUS CONGESTION1
SINOATRIAL BLOCK1
Shock haemorrhagic1
Serum ferritin increased1
Seroconversion test positive1
Septic encephalopathy1
Septic embolus1
SELF-MEDICATION1
Scrotal swelling1
Sciatica1
Rotator cuff syndrome1
RIGHT VENTRICULAR FAILURE1
Rhinalgia1
RESUSCITATION1
Restrictive cardiomyopathy1
Restlessness1
Resting tremor1
RESPIRATORY SYNCYTIAL VIRUS TEST POSITIVE1
RESPIRATORY DISTRESS1
RENAL VEIN THROMBOSIS1
Renal tubular injury1
RENAL TUBULAR ACIDOSIS1
Renal injury1
RENAL HYPERTENSION1
Renal haemorrhage1
Renal function test abnormal1
RENAL FAILURE CHRONIC1
RENAL CYST1
RENAL CELL CARCINOMA STAGE UNSPECIFIED1
RENAL ABSCESS1
Relapsing fever1
Regurgitation1
Refractoriness to platelet transfusion1
Red cell distribution width increased1
Red blood cell hypochromic morphology present1
RECURRENT CANCER1
Reaction to drug excipients1
Raynaud's phenomenon1
RASH MACULAR1
Rash generalised1
RALES1
QUADRIPARESIS1
Pyomyositis1
Puncture site infection1
Pulmonary thrombosis1
Pulmonary resection1
Pulmonary nodular lymphoid hyperplasia1
PULMONARY HILAR ENLARGEMENT1
PULMONARY FIBROSIS1
Pulmonary congestion1
Pulmonary cavitation1
Psychotic symptom1
Pruritus genital1
Protein deficiency1
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY1
Product use complaint1
Product storage error1
Product preparation issue1
Product physical issue1
Product origin unknown1
Product odour abnormal1
Product label issue1
Product expiration date issue1
Product dispensing issue1
Product design issue1
Product contamination physical1
Product availability issue1
Product administration error1
Proctalgia1
Prevertebral soft tissue swelling of cervical space1
Premature delivery1
Premature baby1
Potentiating drug interaction1
POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER1
POST PROCEDURAL INFECTION1
Polydipsia1
POISONING1
PO2 decreased1
PNEUMOTHORAX1
Pneumonia staphylococcal1
Pneumonia respiratory syncytial viral1
Pneumonia pseudomonal1
PNEUMONIA NECROTISING1
Pneumonia legionella1
Pneumonia klebsiella1
Pneumonia aspiration1
Pneumonectomy1
Pneumocystis jirovecii pneumonia1
Pneumococcal sepsis1
PLEURITIC PAIN1
PLEURAL INFECTION1
Placental insufficiency1
PITTING OEDEMA1
Physical disability1
Pharyngeal oedema1
Pharyngeal abscess1
PERITONSILLAR ABSCESS1
PERITONITIS1
Peritoneal candidiasis1
Peripheral venous disease1
PERIPHERAL MOTOR NEUROPATHY1
Peripheral artery thrombosis1
Peptic ulcer1
Patent ductus arteriosus1
Partial seizures with secondary generalisation1
PARTIAL SEIZURES1
Parenteral nutrition1
PARANOIA1
Paralysis1
Panic attack1
PANCREATIC CYST1
Palmar erythema1
Osteonecrosis1
Osteomyelitis1
Orthostatic hypotension1
ORGANISING PNEUMONIA1
ORAL INTAKE REDUCED1
ORAL FUNGAL INFECTION1
Oral candidiasis1
Opsoclonus myoclonus1
Ophthalmic artery thrombosis1
Oesophageal haemorrhage1
Oesophageal carcinoma1
ODYNOPHAGIA1
Ocular icterus1
Ocular hyperaemia1
Obstructive airways disorder1
NPM1 gene mutation1
NON-OBSTRUCTIVE CARDIOMYOPATHY1
Nodule1
Nocardiosis1
NO ADVERSE DRUG EFFECT1
Neutrophilic dermatosis1
Neutrophil count abnormal1
Neutropenic infection1
Neuromyopathy1
Neurological symptom1
NEUROLOGICAL DECOMPENSATION1
NERVOUSNESS1
NEOPLASM PROGRESSION1
Necrosis1
Nasal discomfort1
Nasal congestion1
N-terminal prohormone brain natriuretic peptide increased1
MYOPATHY1
Myocardial ischaemia1
MYELOID LEUKAEMIA1
Mycotic endophthalmitis1
Mycobacterium avium complex infection1
Musculoskeletal disorder1
MUSCLE STRAIN1
Mouth haemorrhage1
Monoparesis1
MONOCYTE PERCENTAGE INCREASED1
Monocyte count increased1
Molluscum contagiosum1
Mobility decreased1
Mitral valve disease1
Microangiopathy1
Metastatic squamous cell carcinoma1
METASTASIS1
Metastases to soft tissue1
METASTASES TO MENINGES1
Metapneumovirus infection1
MESENTERIC VEIN THROMBOSIS1
Menorrhagia1
Meningitis aspergillus1
MENINGITIS1
Medication residue present1
Mechanical ventilation1
Mean cell volume increased1
Mean cell volume1
Mean cell haemoglobin increased1
Maternal exposure during delivery1
Mastication disorder1
Malignant hypertension1
Lymphocyte percentage decreased1
Lymphocyte count increased1
Lung transplant rejection1
Lung transplant1
LUNG OPERATION1
Lower respiratory tract infection fungal1
Loss of employment1
Liver transplant rejection1
LIVER OPERATION1
Liquid product physical issue1
Lipase increased1
Lip swelling1
Lip oedema1
Lip exfoliation1
Lip blister1
Limb mass1
LICHENOID KERATOSIS1
Leukoplakia oral1
LEUKOCYTOCLASTIC VASCULITIS1
Leukaemic infiltration1
Leukaemia cutis1
LEG AMPUTATION1
Left atrial hypertrophy1
LEFT ATRIAL DILATATION1
Large intestine polyp1
LARGE INTESTINE PERFORATION1
Large intestinal polypectomy1
LARGE INTESTINAL OBSTRUCTION1
LACERATION1
Jugular vein thrombosis1
Joint swelling1
JOINT EFFUSION1
Jaundice cholestatic1
Ischaemic cardiomyopathy1
Intracranial pressure increased1
INTRA-ABDOMINAL HAEMORRHAGE1
Intra-abdominal haematoma1
INTESTINAL ULCER1
INTESTINAL ISCHAEMIA1
INTESTINAL DILATATION1
Intervertebral disc protrusion1
International normalised ratio increased1
INTENTIONAL OVERDOSE1
Intention tremor1
Infusion site swelling1
Infusion site pain1
Infusion site extravasation1
Influenza1
Infective spondylitis1
Infective pulmonary exacerbation of cystic fibrosis1
Infectious pleural effusion1
INFECTED SKIN ULCER1
Increased tendency to bruise1
Incorrect drug administration duration1
Incorrect dosage administered1
INCISION SITE ABSCESS1
Impaired healing1
Immunosuppressant drug level decreased1
Immune thrombocytopenia1
Illness1
ILEITIS1
Ileal stenosis1
IDIOPATHIC PNEUMONIA SYNDROME1
Idiopathic intracranial hypertension1
IATROGENIC INJURY1
HYPOREFLEXIA1
HYPOPROTEINAEMIA1
Hypopituitarism1
Hypokinesia1
Hypogonadism1
Hypofibrinogenaemia1
HYPOALBUMINAEMIA1
Hypervolaemia1
HYPERTROPHY OF TONGUE PAPILLAE1
Hypertransaminasaemia1
HYPERSOMNIA1
HYPERSENSITIVITY1
Hyperleukocytosis1
Hyperkeratosis1
Hyperhomocysteinaemia1
Hyperhidrosis1
Hypercholesterolaemia1
HYPERCAPNIA1
Hyperaesthesia1
Hyperadrenalism1
Hydrocholecystis1
HUMAN HERPESVIRUS 6 INFECTION1
Human epidermal growth factor receptor increased1
Hordeolum1
Histiocytosis haematophagic1
Hip arthroplasty1
High density lipoprotein decreased1
HEPATOSPLENIC CANDIDIASIS1
Hepatitis B1
HEPATIC STEATOSIS1
HEPATIC SIDEROSIS1
Hepatic necrosis1
HEPATIC CONGESTION1
Hemianaesthesia1
Heart transplant1
Hallucination, auditory1
HAEMOSIDEROSIS1
Haemorrhagic ovarian cyst1
Haemorrhagic erosive gastritis1
Haemorrhagic cerebral infarction1
Haemolysis1
Haemoglobin abnormal1
Haemodynamic test abnormal1
Haemodynamic instability1
Haematoma1
Haematemesis1
Growth failure1
Granuloma1
Granulocytosis1
Granulocytopenia1
GRAFT DYSFUNCTION1
Glomerulonephritis acute1
GLASGOW COMA SCALE ABNORMAL1
Gingival pain1
Genital haemorrhage1
General symptom1
Gastrointestinal obstruction1
Gastrointestinal mucormycosis1
GASTROINTESTINAL HYPOMOTILITY1
GASTROENTERITIS SALMONELLA1
Gastroenteritis clostridial1
Gastritis1
GASTRIC ULCER HAEMORRHAGE1
Gastric ulcer1
Gastric haemorrhage1
GASTRIC DISORDER1
Gastric dilatation1
Gastric bypass1
Furuncle1
FUNGAL SKIN INFECTION1
Fungal rhinitis1
FUNGAL PERITONITIS1
Fungal disease carrier1
Food refusal1
Folliculitis1
FLUSHING1
FLUID IMBALANCE1
Flatulence1
FIBRIN D DIMER INCREASED1
FEELING JITTERY1
Feeling hot1
Feeding disorder1
Failure to thrive1
Faeces discoloured1
Facial wasting1
Facial paralysis1
EYELID OEDEMA1
Eye pruritus1
Eye pain1
Eye oedema1
EYE INJURY1
Extremity necrosis1
Exposure to toxic agent1
Expired drug administered1
EXOSTOSIS1
Escherichia test positive1
ESCHERICHIA SEPSIS1
ESCHERICHIA INFECTION1
Erythema nodosum1
Eructation1
Epigastric discomfort1
EPHELIDES1
Eosinophilia1
Enzyme inhibition1
ENTEROCOLITIS BACTERIAL1
ENTEROCOLITIS1
ENTEROBACTER TEST POSITIVE1
Enteritis1
Enteral nutrition1
Endotracheal intubation1
End stage renal disease1
ENCEPHALITIS VIRAL1
Encephalitis fungal1
ENCEPHALITIS BRAIN STEM1
EMPYEMA1
Emotional disorder1
Electrocardiogram T wave inversion1
Electrocardiogram ST segment depression1
ELECTROCARDIOGRAM QT CORRECTED INTERVAL PROLONGED1
Electrocardiogram PR shortened1
ELECTROCARDIOGRAM CHANGE1
Ecchymosis1
EAR PAIN1
DYSPHONIA1
Dyshidrotic eczema1
DYSARTHRIA1
Duodenitis1
Drug screen positive1
Drug screen negative1
Drug chemical incompatibility1
Disseminated cryptococcosis1
Disease complication1
Discharge1
DIPHTHERIA1
DILATATION ATRIAL1
Diathermy1
Diarrhoea infectious1
Diabetes insipidus1
Dermatitis herpetiformis1
Dermatitis bullous1
DEPRESSION1
Depressed mood1
DEMYELINATING POLYNEUROPATHY1
DELUSION1
Deep vein thrombosis1
Decubitus ulcer1
Deafness unilateral1
DEAFNESS BILATERAL1
Cytomegalovirus viraemia1
Cytomegalovirus infection reactivation1
CYSTITIS RADIATION1
Cystic fibrosis lung1
Cushingoid1
CULTURE URINE POSITIVE1
CREPITATIONS1
COVID-19 pneumonia1
CORONA VIRUS INFECTION1
Contusion1
Conjunctival hyperaemia1
Complications of transplanted lung1
COMMUNICATION DISORDER1
Colour blindness acquired1
Coeliac disease1
COAGULOPATHY1
Clostridium difficile infection1
Clostridium bacteraemia1
CLONIC CONVULSION1
Clonal evolution1
Circumstance or information capable of leading to device use error1
CIRCULATORY COLLAPSE1
CHRONIC OBSTRUCTIVE PULMONARY DISEASE1
Chronic graft versus host disease in skin1
Chronic graft versus host disease in liver1
Chronic graft versus host disease in eye1
Chronic graft versus host disease1
Chronic disease1
Chondrocalcinosis pyrophosphate1
Cholestatic liver injury1
Cholecystitis1
Cholangitis acute1
Chimerism1
Chemotherapeutic drug level increased1
CEREBROVASCULAR ACCIDENT1
Cerebral toxoplasmosis1
CEREBRAL INFARCTION1
Cerebral haemorrhage1
Cerebral artery stenosis1
Cerebellar syndrome1
CEREBELLAR HAEMORRHAGE1
CENTRAL PONTINE MYELINOLYSIS1
CENTRAL NERVOUS SYSTEM LYMPHOMA1
CENTRAL NERVOUS SYSTEM INFECTION1
Central nervous system fungal infection1
Catheter site related reaction1
Catheter site pain1
Catheter site inflammation1
CATHETER SITE INFECTION1
Catheter site haemorrhage1
Catheter site exfoliation1
CATHETER RELATED INFECTION1
Cardiovascular insufficiency1
CARDIOMYOPATHY1
CARDIOMEGALY1
Cardiogenic shock1
Cardiac myxoma1
CARDIAC MURMUR1
Cardiac failure acute1
Cardiac dysfunction1
Carbon dioxide increased1
Carbon dioxide decreased1
Cancer pain1
Caesarean section1
Bursitis1
Burkholderia cepacia complex sepsis1
Bronchospasm1
Bronchopulmonary aspergillosis allergic1
BRONCHOPNEUMONIA1
Bronchoalveolar lavage abnormal1
Bronchiolitis obliterans syndrome1
Bronchiolitis1
Bronchiectasis1
BRAIN INJURY1
Brain herniation1
BRADYPNOEA1
Bone density decreased1
Body temperature increased1
Blood urea decreased1
Blood triglycerides increased1
Blood test abnormal1
Blood sodium increased1
Blood product transfusion dependent1
Blood pressure abnormal1
Blood phosphorus increased1
BLOOD PH DECREASED1
Blood lactate dehydrogenase decreased1
BLOOD DISORDER1
Blood creatine phosphokinase increased1
BLOOD CREATINE INCREASED1
Blood creatine decreased1
Blood creatine abnormal1
Blood count abnormal1
Blood cholesterol decreased1
Blood chloride increased1
Blood bicarbonate increased1
Blood bicarbonate decreased1
Blood alkaline phosphatase decreased1
BLOOD ALBUMIN INCREASED1
Blister1
Blindness unilateral1
BLINDNESS CORTICAL1
BLEEDING TIME PROLONGED1
Blast cell count increased1
BILIARY DILATATION1
Behcet's syndrome1
Bedridden1
Bacterial test positive1
BACTERIAL SEPSIS1
BACTERIAL DISEASE CARRIER1
B precursor type acute leukaemia1
Autonomic neuropathy1
Autoimmune haemolytic anaemia1
Atypical pneumonia1
ATRIOVENTRICULAR BLOCK FIRST DEGREE1
Atrioventricular block1
ATRIAL FLUTTER1
ATELECTASIS1
Ataxia1
ASPERGILLUS TEST POSITIVE1
Aspartate aminotransferase1
ARTHROPATHY1
ARTHRITIS BACTERIAL1
Artery dissection1
Arterial haemorrhage1
Apparent mineralocorticoid excess1
Apparent life threatening event1
Apolipoprotein B increased1
Apolipoprotein A-I decreased1
APLASIA PURE RED CELL1
Aphasia1
Apathy1
ANOREXIA1
Angiokeratoma1
Androgenetic alopecia1
Androgen deficiency1
Anal pruritus1
Anal haemorrhage1
Anal fissure1
ANAEMIA HAEMOLYTIC AUTOIMMUNE1
AMAUROSIS1
Allogenic stem cell transplantation1
Allogenic bone marrow transplantation therapy1
Alanine aminotransferase1
Aggression1
Adverse reaction1
Adrenocortical insufficiency acute1
Adenovirus infection1
ACUTE TONSILLITIS1
Acute promyelocytic leukaemia differentiation syndrome1
Acute prerenal failure1
Acute myelomonocytic leukaemia1
Acute myeloid leukaemia (in remission)1
ACUTE GRAFT VERSUS HOST DISEASE1
Acute coronary syndrome1
Acute febrile neutrophilic dermatosis1
Activated partial thromboplastin time shortened1
Acquired corneal dystrophy1
Acanthamoeba keratitis1
ABSCESS FUNGAL1
Abdominal wall haemorrhage1
Abdominal operation1
Abdominal mass1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
Q9UNU6 3800 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CP8B1_HUMAN



Toxicity information:

Toxicity type: N/A



External links:

ChEBML: CHEMBL1397
DrugBank: DB01263