nelfinavir


EMA29



General information:


Withdrawn ID: EMA29
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): J05AE04
Molecular Formula: C32H45N3O4S
Molweight: 567.782



Withdrawal information:


Withdrawn due to drug safety reasons:No



Side-effects:

Total reported cases (submitted by medical professionals) with nelfinavir as primary suspect: 288


Reported final outcomes:
Hospitalization (initial or prolonged): 104
Congenital anomaly: 59
Life-Threatening condition: 18
Death: 17
Disability: 6
Intervention required to prevent permanent impairment/damage: 5


Reported side-effects:

Side-effect Case number
DRUG EXPOSURE DURING PREGNANCY123
CAESAREAN SECTION30
PREMATURE BABY28
ABORTION SPONTANEOUS18
PREGNANCY17
CONGENITAL ANOMALY16
DIARRHOEA14
NEONATAL DISORDER12
Maternal exposure during pregnancy12
MATERNAL DRUGS AFFECTING FOETUS12
ANAEMIA12
HYPERTRIGLYCERIDAEMIA11
ANAEMIA NEONATAL10
HYPERLACTACIDAEMIA9
VOMITING8
INTRA-UTERINE DEATH8
CARDIAC MURMUR8
STILLBIRTH7
PREMATURE RUPTURE OF MEMBRANES7
PREMATURE LABOUR7
PLATELET COUNT INCREASED7
NAUSEA7
GASTROINTESTINAL DISORDER7
DRUG INTERACTION7
BLOOD LACTATE DEHYDROGENASE INCREASED7
ASPARTATE AMINOTRANSFERASE INCREASED7
ASCITES7
ABDOMINAL DISTENSION7
WEIGHT DECREASED6
SMALL FOR DATES BABY6
PLATELET COUNT DECREASED6
LABORATORY TEST ABNORMAL6
HAEMOGLOBIN DECREASED6
GASTROOESOPHAGEAL REFLUX DISEASE6
FOETAL DISTRESS SYNDROME6
CYTOLYTIC HEPATITIS6
COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS6
BLOOD LACTIC ACID INCREASED6
BLOOD CREATININE INCREASED6
ALANINE AMINOTRANSFERASE INCREASED6
TRISOMY 215
OLIGOHYDRAMNIOS5
NEUTROPENIA NEONATAL5
NEUTROPENIA5
HYPOTENSION5
ELECTROCARDIOGRAM QT PROLONGED5
CRYPTORCHISM5
CONVULSION5
ASTHENIA5
ABORTION INDUCED5
ABDOMINAL PAIN UPPER5
ABDOMINAL PAIN5
ABDOMINAL HERNIA5
WHITE BLOOD CELL COUNT DECREASED4
ULTRASOUND ANTENATAL SCREEN ABNORMAL4
TORSADE DE POINTES4
TALIPES4
POLYDACTYLY4
PLEURAL EFFUSION4
PLACENTAL DISORDER4
PATENT DUCTUS ARTERIOSUS4
NEUROPATHY PERIPHERAL4
NEONATAL RESPIRATORY DISTRESS SYNDROME4
NEONATAL HEPATOMEGALY4
MATERNAL EXPOSURE TIMING UNSPECIFIED4
LACTATE PYRUVATE RATIO INCREASED4
HYPERTENSION4
HEPATIC ENZYME INCREASED4
DIABETES MELLITUS4
CONGENITAL HYDRONEPHROSIS4
CHEST PAIN4
BLOOD CREATINE PHOSPHOKINASE INCREASED4
ATRIAL SEPTAL DEFECT4
VERTIGO3
THROMBOCYTOPENIA3
STRABISMUS3
STEVENS-JOHNSON SYNDROME3
SPLENOMEGALY3
SLEEP DISORDER3
SICKLE CELL ANAEMIA3
RASH3
PLACENTAL INSUFFICIENCY3
NO ADVERSE EVENT3
MICROGNATHIA3
MACROCYTOSIS3
LYMPHOPENIA3
LIVER DISORDER3
LIPODYSTROPHY ACQUIRED3
LIPASE INCREASED3
LACTIC ACIDOSIS3
HYPOSPADIAS3
HYDRONEPHROSIS3
HEPATIC CIRRHOSIS3
GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY3
GAMMA-GLUTAMYLTRANSFERASE INCREASED3
Foetal exposure during pregnancy3
FOETAL DISORDER3
EPILEPSY3
DYSPNOEA3
DIZZINESS3
DEVELOPMENTAL DELAY3
DEATH3
CONGENITAL ATRIAL SEPTAL DEFECT3
CARDIOMEGALY3
C-REACTIVE PROTEIN INCREASED3
BLOOD KETONE BODY INCREASED3
ARTHRALGIA3
ANAEMIA MACROCYTIC3
VISUAL DISTURBANCE2
VIRAL LOAD INCREASED2
VENTRICULAR SEPTAL DEFECT2
VENTRICULAR HYPERTROPHY2
VENTRICULAR EXTRASYSTOLES2
TROPONIN INCREASED2
TREMOR NEONATAL2
TRANSIENT TACHYPNOEA OF THE NEWBORN2
TRANSAMINASES INCREASED2
THROMBOCYTHAEMIA2
Therapy cessation2
TACHYCARDIA2
Systemic lupus erythematosus2
SYNCOPE2
Subcutaneous abscess2
SKULL MALFORMATION2
RESPIRATORY FAILURE2
RENAL IMPAIRMENT2
RENAL FAILURE CHRONIC2
Renal failure2
RED BLOOD CELL COUNT DECREASED2
PULMONARY HYPERTENSION2
PULMONARY ARTERY STENOSIS CONGENITAL2
PSYCHOMOTOR RETARDATION2
PROTHROMBIN LEVEL DECREASED2
PRE-ECLAMPSIA2
PHLEBITIS2
PANCYTOPENIA2
PANCREATITIS2
Off label use2
OEDEMA2
OCULAR HYPERAEMIA2
NUCLEAR MAGNETIC RESONANCE IMAGING BRAIN ABNORMAL2
MYOCARDIAL INFARCTION2
MULTIPLE CONGENITAL ABNORMALITIES2
MECONIUM PERITONITIS2
MATERNAL CONDITION AFFECTING FOETUS2
MALAISE2
LYMPHOCYTE COUNT DECREASED2
LOSS OF CONSCIOUSNESS2
LIPOATROPHY2
LEUKOPENIA NEONATAL2
KAPOSI'S SARCOMA2
IMMUNE RECONSTITUTION SYNDROME2
HYPOTONIA NEONATAL2
HYPONATRAEMIA2
HYPOKALAEMIA2
HYPERTONIA2
HYPERTHERMIA2
HYDROCELE2
HERPES ZOSTER2
HERPES VIRUS INFECTION2
HERPES SIMPLEX2
HEPATOTOXICITY2
HEPATOMEGALY2
HEPATITIS CHOLESTATIC2
HEPATIC FUNCTION ABNORMAL2
HEAD DEFORMITY2
HAEMANGIOMA OF SKIN2
GROWTH RETARDATION2
FOETAL GROWTH RETARDATION2
FLATULENCE2
FATIGUE2
FALSE POSITIVE LABORATORY RESULT2
EYELID PTOSIS CONGENITAL2
ERYSIPELAS2
EOSINOPHILIA2
ELECTROCARDIOGRAM ABNORMAL2
ECZEMA2
EBSTEIN'S ANOMALY2
DRUG INTOLERANCE2
DISEASE RECURRENCE2
DISEASE PROGRESSION2
DIALYSIS2
DEPRESSED LEVEL OF CONSCIOUSNESS2
DEAFNESS2
CREATININE RENAL CLEARANCE INCREASED2
COUGH2
CONGENITAL VENTRICULAR SEPTAL DEFECT2
CONGENITAL ANAEMIA2
CONFUSIONAL STATE2
CONDITION AGGRAVATED2
CHEST DISCOMFORT2
CEREBROVASCULAR DISORDER2
CD4 LYMPHOCYTES DECREASED2
BRONCHITIS2
BONE MARROW TOXICITY2
BONE MARROW DEPRESSION2
BLOOD UREA INCREASED2
BLOOD TRIGLYCERIDES INCREASED2
BLOOD CREATININE ABNORMAL2
ATRIOVENTRICULAR BLOCK COMPLETE2
ARRHYTHMIA2
ANOREXIA2
ALBUMINURIA2
AFFECT LABILITY2
ACUTE MYOCARDIAL INFARCTION2
ACUTE MYELOID LEUKAEMIA2
ABORTION MISSED2
Wound dehiscence1
WHITE BLOOD CELL COUNT INCREASED1
WEIGHT INCREASED1
VULVOVAGINITIS1
VULVOVAGINAL PRURITUS1
Volvulus1
VITH NERVE PARALYSIS1
VITAMIN D DECREASED1
VISION BLURRED1
VIRAL MYOCARDITIS1
VIRAL INFECTION1
VESTIBULAR NEURONITIS1
VENTRICULAR TACHYCARDIA1
VENTRICULAR HYPOPLASIA1
VENTRICULAR ARRHYTHMIA1
VENOOCCLUSIVE LIVER DISEASE1
VASCULITIS CEREBRAL1
VASCULAR MALFORMATION PERIPHERAL1
VARICES OESOPHAGEAL1
VAGINAL INFECTION1
URTICARIA GENERALISED1
URINARY TRACT MALFORMATION1
URETHRAL DISORDER1
URETHRAL CYST1
UPPER RESPIRATORY TRACT INFECTION1
Unevaluable event1
ULTRASOUND SCAN ABNORMAL1
UHL'S ANOMALY1
TUBERCULOSIS1
TRISOMY 151
TREMOR1
TREATMENT NONCOMPLIANCE1
TRANSITIONAL CELL CARCINOMA1
TRACHEOBRONCHITIS1
TRACHEAL NEOPLASM1
TOXOPLASMOSIS1
TOXIC SKIN ERUPTION1
Toxic epidermal necrolysis1
TONSILLITIS1
TONGUE DISCOLOURATION1
TINNITUS1
THROMBOCYTOPENIA NEONATAL1
THERAPY NON-RESPONDER1
TESTICULAR ATROPHY1
SURGICAL PROCEDURE REPEATED1
SUPRAVENTRICULAR EXTRASYSTOLES1
SUPPRESSED LACTATION1
STREPTOCOCCAL INFECTION1
STRABISMUS CONGENITAL1
SPORTS INJURY1
SPINA BIFIDA1
SPEECH DISORDER DEVELOPMENTAL1
SPEECH DISORDER1
SOMNOLENCE1
SOCIAL PROBLEM1
SKIN ODOUR ABNORMAL1
SKIN LESION1
Sjogren's syndrome1
SINUSITIS1
SINUS BRADYCARDIA1
SICK SINUS SYNDROME1
SHOULDER DYSTOCIA1
Short-bowel syndrome1
SEPSIS1
SEBORRHOEIC DERMATITIS1
Scrotal disorder1
RUBELLA ANTIBODY POSITIVE1
RIGHT VENTRICULAR FAILURE1
RETINOGRAM ABNORMAL1
RETCHING1
RETAINED PRODUCTS OF CONCEPTION1
REPRODUCTIVE TRACT DISORDER1
Renal disorder1
REGURGITATION OF FOOD1
RECTAL CANCER1
RASH PAPULAR1
RASH MACULO-PAPULAR1
RASH MACULAR1
PYREXIA1
Pyelocaliectasis1
PULMONARY MALFORMATION1
PULMONARY ARTERY ATRESIA1
PULMONARY ARTERIAL WEDGE PRESSURE INCREASED1
PSYCHOMOTOR HYPERACTIVITY1
PSYCHOMOTOR AGITATION1
Pruritus1
PROTHROMBIN TIME SHORTENED1
PROTEIN URINE PRESENT1
Progressive external ophthalmoplegia1
PRODUCTIVE COUGH1
Product use complaint1
PROCEDURAL COMPLICATION1
PREMATURE SEPARATION OF PLACENTA1
PREMATURE CLOSURE OF CRANIAL SUTURES1
POST PROCEDURAL COMPLICATION1
POOR QUALITY SLEEP1
POLYHYDRAMNIOS1
POLLAKIURIA1
PNEUMONIA1
PLACENTAL NECROSIS1
PILONIDAL CYST CONGENITAL1
Photosensitivity reaction1
PHOTOPHOBIA1
PHARYNGITIS1
PERITONITIS BACTERIAL1
Peripheral sensory neuropathy1
Peripheral motor neuropathy1
PERINEAL FISTULA1
PERICARDIAL EFFUSION1
Pelvic abscess1
PATHOLOGICAL FRACTURE1
PAPILLOMA1
PANCREATITIS ACUTE1
PANCREATIC DISORDER1
PAIN IN EXTREMITY1
Osteopenia1
Osteonecrosis1
ORAL CANDIDIASIS1
Ophthalmoplegia1
OESOPHAGEAL STENOSIS1
NONSPECIFIC REACTION1
NODULAR REGENERATIVE HYPERPLASIA1
NODAL RHYTHM1
NO ADVERSE REACTION1
NO ADVERSE EFFECT1
NEURITIS1
NEURALGIA1
Nervous system disorder1
Nephropathy toxic1
Nephrolithiasis1
NEOPLASM1
NEONATAL HYPONATRAEMIA1
NEONATAL ASPIRATION1
NEONATAL ASPHYXIA1
NEONATAL APNOEIC ATTACK1
Nasal operation1
NASAL CONGESTION1
MYOTONIC DYSTROPHY1
MYOCARDITIS1
MYCOBACTERIUM AVIUM COMPLEX INFECTION1
MYASTHENIA GRAVIS1
MUSCLE RIGIDITY1
MULTIPLE-DRUG RESISTANCE1
Multiple fractures1
MOTOR DYSFUNCTION1
MONOCYTE COUNT DECREASED1
MITRAL VALVE INCOMPETENCE1
Mitochondrial toxicity1
MITOCHONDRIAL CYTOPATHY1
MICROCYTIC ANAEMIA1
Microcephaly1
METASTASES TO LUNG1
MENTAL DISORDER1
MENISCUS LESION1
Meningomyelocele1
MENINGOCELE1
MEDICATION ERROR1
MECONIUM ABNORMAL1
MEAN CELL VOLUME INCREASED1
Manufacturing product shipping issue1
MALIGNANT NEOPLASM PROGRESSION1
LYMPHOCYTOSIS1
LUNG INFECTION1
Low birth weight baby1
LIVIDITY1
LIVER FUNCTION TEST ABNORMAL1
LIVE BIRTH1
LIPOSARCOMA RECURRENT1
Lipohypertrophy1
LICHEN PLANUS1
LEUKOPENIA1
LEGAL PROBLEM1
LEFT VENTRICULAR FAILURE1
Kidney malformation1
JOINT ARTHROPLASTY1
JAUNDICE1
INTRAUTERINE INFECTION1
Intestinal atresia1
INTENTIONAL OVERDOSE1
INGUINAL HERNIA1
INFLUENZA1
INFLAMMATION1
IMPETIGO1
ILL-DEFINED DISORDER1
IATROGENIC INJURY1
Hypoxia1
HYPOTONIA1
HYPOTHYROIDISM1
HYPOTHERMIA1
HYPOGLYCAEMIA NEONATAL1
HYPOGLYCAEMIA1
HYPERTROPHY1
HYPERTENSIVE CARDIOMYOPATHY1
HYPERSPLENISM1
HYPERSENSITIVITY1
HYPERLIPIDAEMIA1
Hyperglycaemia1
HYPERCAPNIA1
HYPERAESTHESIA1
HYPERAEMIA1
Hydrocephalus1
HIV test positive1
HILAR LYMPHADENOPATHY1
HERNIA CONGENITAL1
Hepatocellular injury1
HEPATOCELLULAR DAMAGE1
HEPATITIS C1
HEPATITIS1
HEPATIC STEATOSIS1
HEPATIC PAIN1
Hepatic fibrosis1
HEPATIC CONGESTION1
HEMIPLEGIA1
HEMIPARESIS1
Heavy exposure to ultraviolet light1
HEAT RASH1
HEADACHE1
HEAD BANGING1
HAEMORRHAGE1
HAEMOPTYSIS1
HAEMOPHILUS INFECTION1
HAEMATOCRIT DECREASED1
HAEMATEMESIS1
HAEMANGIOMA CONGENITAL1
Gynaecomastia1
GRAND MAL CONVULSION1
GLAUCOMA1
GLASGOW COMA SCALE ABNORMAL1
GINGIVAL DISORDER1
GENERAL PHYSICAL HEALTH DETERIORATION1
GASTROSCHISIS1
GASTROENTERITIS1
GASTRIC PERFORATION1
GAIT DISTURBANCE1
FUNISITIS1
FOREIGN BODY TRAUMA1
FOREIGN BODY1
FORCEPS DELIVERY1
FOLATE DEFICIENCY1
FOETAL TOBACCO EXPOSURE1
FOETAL MALFORMATION1
FOETAL HEART RATE ABNORMAL1
Foetal death1
FOETAL DAMAGE1
FOETAL CARDIAC DISORDER1
FINGER DEFORMITY1
Femur fracture1
FEMORAL NECK FRACTURE1
FEELING DRUNK1
FEEDING PROBLEM IN NEWBORN1
FEEDING DISORDER1
FALL1
FAECES PALE1
FAECES DISCOLOURED1
FACIAL PALSY1
Face oedema1
Eyelid ptosis1
EYE MOVEMENT DISORDER1
EYE INFECTION1
EYE DISORDER1
EXTRASYSTOLES1
Extraocular muscle paresis1
Exposure during pregnancy1
EPSTEIN-BARR VIRUS ANTIBODY POSITIVE1
EPENDYMOMA MALIGNANT1
ENCEPHALOPATHY1
ELECTROCARDIOGRAM ST SEGMENT ABNORMAL1
ELECTROCARDIOGRAM R ON T PHENOMENON1
EJECTION FRACTION ABNORMAL1
EAR PAIN1
EAR INFECTION1
DYSTROPHIA MYOTONICA1
DYSPHONIA1
DYSPHAGIA1
DYSMORPHISM1
Dyslipidaemia1
DYSAESTHESIA1
DUODENAL ULCER HAEMORRHAGE1
DRUG WITHDRAWAL SYNDROME NEONATAL1
DRUG TOXICITY1
DRUG SCREEN POSITIVE1
Drug level increased1
DRUG INEFFECTIVE1
DRUG EXPOSURE BEFORE PREGNANCY1
Drug dose omission1
DRUG DEPENDENCE1
DISTURBANCE IN ATTENTION1
Diplopia1
DILATATION INTRAHEPATIC DUCT CONGENITAL1
DILATATION ATRIAL1
DIFFICULTY IN WALKING1
DERMATITIS BULLOUS1
DEPRESSION1
DEPRESSED MOOD1
DELIRIUM1
DEHYDRATION1
DECREASED APPETITE1
DEATH NEONATAL1
DEAFNESS UNILATERAL1
DEAFNESS NEUROSENSORY1
DEAFNESS CONGENITAL1
CYTOMEGALOVIRUS INFECTION1
CYTOMEGALOVIRUS ANTIBODY POSITIVE1
CYANOSIS1
Cushing's syndrome1
CORONARY ARTERY STENOSIS1
CORONARY ARTERY ATHEROSCLEROSIS1
CORNEAL OPACITY1
CONVULSION NEONATAL1
CONSTIPATION1
CONNECTIVE TISSUE DISORDER1
CONGESTIVE CARDIOMYOPATHY1
CONGENITAL TRICUSPID VALVE ATRESIA1
CONGENITAL PULMONARY HYPERTENSION1
CONGENITAL NOSE MALFORMATION1
CONGENITAL MUSCULOSKELETAL ANOMALY1
CONGENITAL HAND MALFORMATION1
CONGENITAL CYSTIC LUNG1
CONGENITAL CYSTIC KIDNEY DISEASE1
CONGENITAL ADRENAL GLAND HYPOPLASIA1
CONDYLOMA ACUMINATUM1
CLEFT LIP AND PALATE1
Chronic kidney disease1
CHROMOSOME ANALYSIS ABNORMAL1
CHOLESTASIS1
Cholelithiasis1
Cholecystitis acute1
Cholecystitis1
Cholangitis1
CERVICAL INCOMPETENCE1
CEREBRAL TOXOPLASMOSIS1
CELLULITIS1
CATHETER SITE INFLAMMATION1
CARDIAC DISORDER1
CARDIAC ARREST1
CANDIDIASIS1
Campylobacter gastroenteritis1
CALCINOSIS1
BRONCHOSPASM1
BREECH DELIVERY1
Brain injury1
BRADYCARDIA1
Bone loss1
Bone density decreased1
BODY TEMPERATURE INCREASED1
BLOOD URIC ACID INCREASED1
BLOOD UREA DECREASED1
BLOOD PYRUVIC ACID DECREASED1
BLOOD POTASSIUM INCREASED1
BLOOD MAGNESIUM INCREASED1
BLOOD LACTIC ACID1
BLOOD KETONE BODY1
BLOOD IRON1
BLOOD HIV RNA INCREASED1
BLOOD GLUCOSE INCREASED1
BLOOD GLUCOSE DECREASED1
Blood cortisol decreased1
Blood corticotrophin decreased1
BLOOD CHOLESTEROL DECREASED1
BLOOD BILIRUBIN INCREASED1
BLOOD ALKALINE PHOSPHATASE INCREASED1
BLOOD ALCOHOL INCREASED1
BLADDER HYPERTROPHY1
BETA HAEMOLYTIC STREPTOCOCCAL INFECTION1
BALANCE DISORDER1
Autoimmune thyroiditis1
ATRIOVENTRICULAR EXTRASYSTOLES1
ATHEROSCLEROSIS1
ASTHMATIC CRISIS1
ASEPTIC NECROSIS BONE1
ARTHROPATHY1
ARTERIOVENOUS MALFORMATION1
ARNOLD-CHIARI MALFORMATION1
APPENDICITIS1
APLASTIC ANAEMIA1
APHTHOUS STOMATITIS1
AORTIC VALVE REPLACEMENT1
AORTIC VALVE INCOMPETENCE1
AORTA HYPOPLASIA1
ANXIETY1
ANOGENITAL WARTS1
ANOGENITAL DYSPLASIA1
ANGINA PECTORIS1
ANAPHYLACTOID REACTION1
ANAL PRURITUS1
ANAL ATRESIA1
AMNIOTIC CAVITY DISORDER1
AMNIORRHOEA1
ALPHA 1 FOETOPROTEIN INCREASED1
Alpha 1 foetoprotein amniotic fluid increased1
ALPHA 1 FOETOPROTEIN ABNORMAL1
ALOPECIA1
Alcohol intolerance1
AIDS ENCEPHALOPATHY1
ADRENOGENITAL SYNDROME1
ACUTE VESTIBULAR SYNDROME1
ACUTE PULMONARY OEDEMA1
ACCIDENTAL OVERDOSE1
ABNORMAL BEHAVIOUR1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P08183 1700 ATP-dependent translocase ABCB1 MDR1_HUMAN



Toxicity information:

Toxicity type: N/A



External links:

ChEBML: CHEMBL584
DrugBank: DB00220