doripenem


EMA12



General information:


Withdrawn ID: EMA12
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): J01DH04
Molecular Formula: C15H24N4O6S2
Molweight: 420.504



Withdrawal information:


Withdrawn due to drug safety reasons:No



Side-effects:

Total reported cases (submitted by medical professionals) with doripenem as primary suspect: 405


Reported final outcomes:
Death: 137
Hospitalization (initial or prolonged): 114
Life-Threatening condition: 50
Disability: 7


Reported side-effects:

Side-effect Case number
HEPATIC FUNCTION ABNORMAL34
CONVULSION31
Sepsis20
OFF LABEL USE18
PNEUMONIA16
Liver disorder15
DEATH14
SHOCK13
Renal impairment13
Platelet count decreased13
DIARRHOEA13
Respiratory failure12
PYREXIA12
WHITE BLOOD CELL COUNT DECREASED10
RENAL FAILURE ACUTE10
INTERSTITIAL LUNG DISEASE9
SEPTIC SHOCK8
RENAL FAILURE8
PANCYTOPENIA8
ASPARTATE AMINOTRANSFERASE INCREASED8
ALANINE AMINOTRANSFERASE INCREASED8
TUBULOINTERSTITIAL NEPHRITIS7
THROMBOCYTOPENIA7
ANAEMIA7
MULTI-ORGAN FAILURE6
EOSINOPHIL COUNT INCREASED6
BLOOD CREATININE INCREASED6
BLOOD BILIRUBIN INCREASED6
ACUTE RESPIRATORY DISTRESS SYNDROME6
WHITE BLOOD CELL COUNT INCREASED5
TOXIC EPIDERMAL NECROLYSIS5
SUPERINFECTION5
JAUNDICE5
INFECTION5
HYPERKALAEMIA5
Drug-induced liver injury5
BLOOD UREA INCREASED5
AGRANULOCYTOSIS5
Urticaria4
Seizure4
RASH4
NEUTROPHIL COUNT DECREASED4
HEPATIC FAILURE4
GRAND MAL CONVULSION4
DYSPNOEA4
DRUG INEFFECTIVE4
DISSEMINATED INTRAVASCULAR COAGULATION4
DEPRESSED LEVEL OF CONSCIOUSNESS4
BACTERAEMIA4
TREATMENT FAILURE3
Renal disorder3
PULMONARY HAEMORRHAGE3
Pseudomembranous colitis3
Pneumothorax3
Platelet count increased3
PERITONITIS3
LEUKOPENIA3
HYPERGLYCAEMIA3
HEPATITIS FULMINANT3
HEPATIC ENZYME INCREASED3
HAEMATURIA3
General physical health deterioration3
ERYTHEMA MULTIFORME3
ENCEPHALOPATHY3
DRUG PRESCRIBING ERROR3
Drug eruption3
C-REACTIVE PROTEIN INCREASED3
BONE MARROW FAILURE3
BLOOD PRESSURE DECREASED3
Blood creatine phosphokinase increased3
BLOOD ALKALINE PHOSPHATASE INCREASED3
Acute kidney injury3
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS3
VOMITING2
Toxic encephalopathy2
Thrombotic microangiopathy2
STEVENS-JOHNSON SYNDROME2
Rhabdomyolysis2
Respiratory disorder2
RED BLOOD CELL COUNT DECREASED2
RASH PRURITIC2
RASH MACULO-PAPULAR2
RASH GENERALISED2
RASH ERYTHEMATOUS2
PSEUDOMONAS INFECTION2
PROSTATE CANCER2
Prescribed overdose2
PNEUMONIA ASPIRATION2
PATHOGEN RESISTANCE2
OXYGEN SATURATION DECREASED2
Oedema peripheral2
Neutropenia2
Nausea2
MYOCARDIAL INFARCTION2
MUSCLE SPASMS2
Medication error2
Lung neoplasm malignant2
LEUKAEMIA2
INCORRECT DOSE ADMINISTERED2
Ileus paralytic2
HYPOVOLAEMIC SHOCK2
HYPONATRAEMIA2
HEADACHE2
HALLUCINATION2
HAEMORRHAGE INTRACRANIAL2
HAEMORRHAGE2
GRANULOCYTE COUNT DECREASED2
Graft versus host disease2
Gastrointestinal haemorrhage2
GASTROENTERITIS STAPHYLOCOCCAL2
Gamma-glutamyltransferase increased2
Febrile neutropenia2
EPILEPSY2
DRUG RESISTANCE2
CONDITION AGGRAVATED2
CLOSTRIDIUM DIFFICILE COLITIS2
Cholestasis2
CHILLS2
CEREBRAL HAEMORRHAGE2
Cardiac arrest2
Candida infection2
BRONCHOPULMONARY ASPERGILLOSIS2
BRADYCARDIA2
BLOOD SODIUM INCREASED2
BLOOD PRESSURE INCREASED2
Blood potassium increased2
BLOOD POTASSIUM DECREASED2
BLOOD LACTATE DEHYDROGENASE INCREASED2
BLISTER2
ARRHYTHMIA2
ANAPHYLACTIC SHOCK2
Amylase increased2
ALTERED STATE OF CONSCIOUSNESS2
Adenovirus infection2
ACUTE HEPATIC FAILURE2
Abdominal pain2
Zygomycosis1
Wound infection fungal1
WEIGHT INCREASED1
VENTRICULAR TACHYCARDIA1
URINARY TRACT INFECTION1
UPPER GASTROINTESTINAL HAEMORRHAGE1
Trichosporon infection1
TORSADE DE POINTES1
Thrombocytosis1
TACHYPNOEA1
TACHYCARDIA1
SYSTEMIC CANDIDA1
Subarachnoid haemorrhage1
SPEECH DISORDER1
Small intestinal haemorrhage1
Severe acute respiratory syndrome1
REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME1
Renal cyst1
Rash morbilliform1
Q FEVER1
PYURIA1
PUTAMEN HAEMORRHAGE1
PULMONARY SEPSIS1
PULMONARY EMBOLISM1
Pruritus1
PROTHROMBIN TIME PROLONGED1
Postictal paralysis1
POST PROCEDURAL HAEMORRHAGE1
Pneumonitis1
PNEUMONIA STAPHYLOCOCCAL1
PNEUMONIA KLEBSIELLA1
Pneumonia fungal1
PNEUMOCYSTIS JIROVECI PNEUMONIA1
Pleural effusion1
Pharyngitis1
PHARYNGEAL INFLAMMATION1
Petit mal epilepsy1
PETECHIAE1
PARTIAL SEIZURES1
Pancreatitis chronic1
PANCREATITIS ACUTE1
Pancreatic disorder1
PANCREATIC CARCINOMA1
Pain1
OVERDOSE1
OROPHARYNGEAL PAIN1
Organising pneumonia1
Oral candidiasis1
OEDEMA1
No therapeutic response1
Neurogenic bladder1
NEPHRITIS INTERSTITIAL1
Neoplasm malignant1
MUSCLE TWITCHING1
MITRAL VALVE PROLAPSE1
Metastases to pelvis1
Metabolic acidosis1
MENTAL STATUS CHANGES1
Maternal exposure during pregnancy1
Lymphoma1
Lung disorder1
LUNG ABSCESS1
LOWER RESPIRATORY TRACT INFECTION1
LOSS OF CONSCIOUSNESS1
Long QT syndrome1
Localised oedema1
Liver function test abnormal1
Liquid product physical issue1
LEUKOENCEPHALOPATHY1
LEUKOCYTOSIS1
Large intestine perforation1
LABORATORY TEST ABNORMAL1
Kawasaki's disease1
Jaundice cholestatic1
INTESTINAL OBSTRUCTION1
Insomnia1
Injury1
Infective spondylitis1
INCORRECT DRUG ADMINISTRATION RATE1
Impaired healing1
Illusion1
Ileus1
Hypokalaemia1
Hypoglycaemic coma1
HYPERSENSITIVITY1
Hyperplastic cholecystopathy1
HYPERNATRAEMIA1
Hyperhidrosis1
Hyperbilirubinaemia1
Hydrops foetalis1
Histiocytosis haematophagic1
Hepatomegaly1
Hepatitis1
Hepatic steatosis1
Heparin-induced thrombocytopenia1
HEAT RASH1
HEART RATE INCREASED1
HEARING IMPAIRED1
Hallucination, auditory1
Haemoptysis1
Haemoglobin decreased1
Graft versus host disease in skin1
GLOMERULONEPHRITIS1
Generalised tonic-clonic seizure1
GASTRIC CANCER1
Gallbladder polyp1
FUNGAL SEPSIS1
Fungal infection1
Foetal exposure during pregnancy1
Foetal death1
FLUID RETENTION1
EYELID PTOSIS1
ESCHERICHIA INFECTION1
ERYTHEMA1
Eosinophilia1
ENTEROCOLITIS HAEMORRHAGIC1
ENTEROCOLITIS1
Enteritis1
ENDOCARDITIS BACTERIAL1
ENDOCARDITIS1
Enanthema1
EMPYEMA1
DYSARTHRIA1
DUODENAL ULCER1
DRUG TOXICITY1
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS1
DRUG EFFECT DECREASED1
Drug dispensing error1
Drug administered to patient of inappropriate age1
Diffuse alveolar damage1
Device related infection1
Dermatitis bullous1
Delirium1
DEHYDRATION1
Cytomegalovirus viraemia1
Cytomegalovirus test positive1
COUGH1
Conjunctivitis1
CONFUSIONAL STATE1
Colour blindness acquired1
Colorectal cancer1
COLONIC FISTULA1
COAGULOPATHY1
Clonic convulsion1
CHOLECYSTITIS1
Cheilitis1
CELLULITIS1
CARDIOMYOPATHY1
Cardiac failure1
CANDIDIASIS1
BRAIN TUMOUR OPERATION1
Brain abscess1
Blood glucose increased1
BLOOD CULTURE POSITIVE1
BLOOD CREATININE DECREASED1
Bacterial pyelonephritis1
Bacterial infection1
Back pain1
Ascites1
ARTHROPATHY1
ARTHRITIS INFECTIVE1
ARTHRALGIA1
ARTERIAL RUPTURE1
ANURIA1
Antidiuretic hormone abnormality1
ANGINA PECTORIS1
ANAEMIA HAEMOLYTIC AUTOIMMUNE1
AGGRESSION1
ADVERSE EVENT1
ACUTE RESPIRATORY FAILURE1
Acute myocardial infarction1
Acute lymphocytic leukaemia1
ACUTE CORONARY SYNDROME1
ACINETOBACTER INFECTION1
Accidental overdose1
Acarodermatitis1





Toxicity information:

Toxicity class: 5
Toxicity type: N/A
LD50: 5000 mg/kg



External links:

ChEBML: CHEMBL491571
DrugBank: N/A