Nimesulide
General information:
| Withdrawn ID: | DB04743 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | M01AX17 |
| M02AA26 | |
| Molecular Formula: | C13H12N2O5S |
| Molweight: | 308.31 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1985 |
| First death: | 2000 |
| First withdrawn: | 2002 |
| Last withdrawn: | 2011 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Nimesulide as primary suspect: | 37 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 22 |
|---|---|
| Life-Threatening condition: | 4 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Anaemia | 8 |
| Gastrointestinal ulcer | 4 |
| Angioedema | 4 |
| Metabolic acidosis | 4 |
| Bone marrow failure | 4 |
| Drug abuse | 3 |
| Pruritus | 3 |
| Pyrexia | 3 |
| ERYTHEMA | 3 |
| Intentional self-injury | 3 |
| Hypotension | 3 |
| Urticaria | 3 |
| Gastric ulcer | 2 |
| Hypocoagulable state | 2 |
| Erosive oesophagitis | 2 |
| Hypertension | 2 |
| Epistaxis | 2 |
| Drug interaction | 2 |
| Rash | 2 |
| Suicide attempt | 2 |
| Rectal haemorrhage | 2 |
| Eyelid oedema | 1 |
| HAEMORRHAGE | 1 |
| ABDOMINAL WALL HAEMATOMA | 1 |
| Accidental exposure to product | 1 |
| Gastroduodenal ulcer | 1 |
| Blood pressure | 1 |
| Chest pain | 1 |
| Fall | 1 |
| Face oedema | 1 |
| Drug hypersensitivity | 1 |
| Chromaturia | 1 |
| ERYTHEMA NODOSUM | 1 |
| Erythema multiforme | 1 |
| Conjunctivitis | 1 |
| Dermatitis bullous | 1 |
| Dyspepsia | 1 |
| Drug reaction with eosinophilia and systemic symptoms | 1 |
| Abdominal pain upper | 1 |
| Overlap syndrome | 1 |
| Tubulointerstitial nephritis | 1 |
| Toxic skin eruption | 1 |
| Toxic epidermal necrolysis | 1 |
| Stevens-Johnson syndrome | 1 |
| Skin erosion | 1 |
| Serum ferritin decreased | 1 |
| Rash papular | 1 |
| Rash maculo-papular | 1 |
| Rash generalised | 1 |
| Rash erythematous | 1 |
| Product use in unapproved indication | 1 |
| Presyncope | 1 |
| Pancreatitis acute | 1 |
| Hepatitis | 1 |
| Overdose | 1 |
| Oliguria | 1 |
| Off label use | 1 |
| Oedema | 1 |
| Obliterative bronchiolitis | 1 |
| Nephropathy | 1 |
| Necrolytic migratory erythema | 1 |
| Melaena | 1 |
| Lymphopenia | 1 |
| Liver disorder | 1 |
| Intentional overdose | 1 |
| HYPERTRANSAMINASAEMIA | 1 |
| Hypersensitivity | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P02545 | 125.9 | Prelamin-A/C | LMNA_HUMAN |
| P05164 | 2100 | Myeloperoxidase | PERM_HUMAN |
| P06280 | 3981.1 | Alpha-galactosidase A | AGAL_HUMAN |
| P16473 | 100 | Thyrotropin receptor | TSHR_HUMAN |
| P23219 | 1226 | Prostaglandin G/H synthase 1 | PGH1_HUMAN |
| P35354 | 600 | Prostaglandin G/H synthase 2 | PGH2_HUMAN |
| Q16665 | 3162.3 | Hypoxia-inducible factor 1-alpha | HIF1A_HUMAN |
Toxicity information:
| Toxicity class: | 3 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 200 mg/kg |
External links:
| ChEBML: | CHEMBL56367 |
|---|---|
| DrugBank: | DB04743 |