Bepridil


DB01244



General information:


Withdrawn ID: DB01244
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): C08EA02
Molecular Formula: C24H34N2O
Molweight: 366.54



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1990



Side-effects:

Total reported cases (submitted by medical professionals) with Bepridil as primary suspect: 14


Reported final outcomes:
Hospitalization (initial or prolonged): 11
Life-Threatening condition: 4
Disability: 1
Death: 1


Reported side-effects:

Side-effect Case number
GAMMA-GLUTAMYLTRANSFERASE INCREASED4
VENTRICULAR FIBRILLATION4
BLOOD LACTATE DEHYDROGENASE INCREASED4
LOSS OF CONSCIOUSNESS3
ASPARTATE AMINOTRANSFERASE INCREASED3
ELECTROCARDIOGRAM QT PROLONGED2
HYPOKALAEMIA2
C-REACTIVE PROTEIN INCREASED2
VENTRICULAR TACHYCARDIA2
AGRANULOCYTOSIS2
THROMBOCYTOPENIA2
ALANINE AMINOTRANSFERASE INCREASED2
TORSADE DE POINTES2
CARDIAC FAILURE1
ACTIVITIES OF DAILY LIVING IMPAIRED1
DYSKINESIA1
DRUG TOXICITY1
DRUG INTERACTION1
CONVULSION1
CHOREOATHETOSIS1
WHITE BLOOD CELL COUNT INCREASED1
CAROTID ARTERY OCCLUSION1
CARDIOMYOPATHY1
CARDIO-RESPIRATORY ARREST1
AGEUSIA1
BONE MARROW DEPRESSION1
BLOOD POTASSIUM DECREASED1
BLOOD CREATINE PHOSPHOKINASE INCREASED1
BLOOD ALKALINE PHOSPHATASE INCREASED1
BASOPHIL COUNT INCREASED1
ATRIAL FIBRILLATION1
ATAXIA1
APALLIC SYNDROME1
ANOREXIA1
MULTI-ORGAN FAILURE1
VENTRICULAR EXTRASYSTOLES1
THROMBOCYTOPENIC PURPURA1
THERAPEUTIC RESPONSE DECREASED1
SYNCOPE1
SHOCK1
SEPSIS1
RHABDOMYOLYSIS1
RENAL FAILURE1
PNEUMONITIS1
OVARIAN CANCER1
NEUTROPHIL PERCENTAGE INCREASED1
NAUSEA1
MYOGLOBIN BLOOD INCREASED1
EOSINOPHIL COUNT INCREASED1
MALAISE1
LYMPHOCYTE STIMULATION TEST POSITIVE1
LYMPHOCYTE COUNT INCREASED1
LIVER DISORDER1
LEUKOENCEPHALOPATHY1
INTERSTITIAL LUNG DISEASE1
HYPERAMMONAEMIA1
HEPATIC FUNCTION ABNORMAL1
HAEMORRHAGE1
GENERAL PHYSICAL HEALTH DETERIORATION1
GASTROINTESTINAL HAEMORRHAGE1
FALL1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
Q12809 22.91 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN
Q13936 1400 Voltage-dependent L-type calcium channel subunit alpha-1C CAC1C_HUMAN
Q14524 3700 Sodium channel protein type 5 subunit alpha SCN5A_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 1955 mg/kg



External links:

ChEBML: CHEMBL1008
DrugBank: DB01244