Cefadroxil


DB01140



General information:


Withdrawn ID: DB01140
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): J01DB05
Molecular Formula: C16H17N3O5S
Molweight: 363.388



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 2003
First withdrawn: 2007
Last withdrawn: 2007



Side-effects:

Total reported cases (submitted by medical professionals) with Cefadroxil as primary suspect: 85


Reported final outcomes:
Hospitalization (initial or prolonged): 41
Life-Threatening condition: 7
Death: 6
Congenital anomaly: 2
Disability: 2
Intervention required to prevent permanent impairment/damage: 1


Reported side-effects:

Side-effect Case number
Drug reaction with eosinophilia and systemic symptoms12
TOXIC EPIDERMAL NECROLYSIS7
NAUSEA7
URTICARIA6
PYREXIA6
Therapeutic product cross-reactivity5
RASH5
VOMITING4
RASH MACULO-PAPULAR4
DYSPNOEA4
DIARRHOEA4
Acute hepatic failure4
MOUTH ULCERATION3
Hypersensitivity3
Erythema multiforme3
Drug hypersensitivity3
BLOOD BILIRUBIN INCREASED3
ARTHRALGIA3
ANAPHYLACTIC SHOCK3
Anaphylactic reaction3
TYPE IV HYPERSENSITIVITY REACTION2
TUBULOINTERSTITIAL NEPHRITIS2
Transaminases increased2
STRABISMUS2
STEVENS-JOHNSON SYNDROME2
SKIN TEST POSITIVE2
Respiratory failure2
RASH MORBILLIFORM2
PURPURA2
Pruritus2
PAIN2
Mental status changes2
Linear IgA disease2
HEPATITIS2
GRAND MAL CONVULSION2
Escherichia infection2
Erythema2
EOSINOPHILIA2
Eosinophil count increased2
DERMATITIS EXFOLIATIVE2
Dermatitis bullous2
Clostridium difficile colitis2
CHEST PAIN2
CHEST DISCOMFORT2
BLOOD ALKALINE PHOSPHATASE INCREASED2
Bacteroides infection2
ANGIOEDEMA2
Agranulocytosis2
ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS2
WOUND1
WHITE BLOOD CELL COUNT DECREASED1
Vision blurred1
VASCULITIS1
ULCER1
TRISMUS1
Tremor1
Treatment failure1
TOOTH DISCOLOURATION1
Tongue discolouration1
THROMBOCYTOPENIA1
Symmetrical drug-related intertriginous and flexural exanthema1
SWOLLEN TONGUE1
SWELLING1
STOMATITIS1
SPINA BIFIDA OCCULTA1
SPINA BIFIDA1
Skin plaque1
SKIN EXFOLIATION1
SERUM SICKNESS1
SEPSIS1
Respiratory disorder1
RENAL FAILURE ACUTE1
RECTAL ABSCESS1
RASH GENERALISED1
PRURITUS GENERALISED1
PRODUCTIVE COUGH1
Product storage error1
PNEUMONIA1
PHARYNGOLARYNGEAL PAIN1
PARAESTHESIA1
PANCREATITIS1
ORAL SOFT TISSUE DISORDER1
OLFACTORY NERVE DISORDER1
Off label use1
Oedema1
Ocular discomfort1
NEUTROPENIA1
Nephropathy1
MYALGIA1
Muscle spasms1
METABOLIC ACIDOSIS1
MEDICATION ERROR1
MALAISE1
Macule1
Lymphadenopathy1
LIVER INJURY1
LIP SWELLING1
Lichenoid keratosis1
Lichen planus1
LEUKOPENIA1
Jaundice1
INFLAMMATION1
Ichthyosis1
Hyperkeratosis1
HYPERKALAEMIA1
HYPERHIDROSIS1
HERPES SIMPLEX1
Hepatotoxicity1
HEPATIC FUNCTION ABNORMAL1
HEPATIC ENZYME ABNORMAL1
HENOCH-SCHONLEIN PURPURA1
Gamma-glutamyltransferase increased1
FOETAL EXPOSURE DURING PREGNANCY1
Fear1
FACE OEDEMA1
EYELID OEDEMA1
EPISTAXIS1
Eczema1
Dysuria1
DYSPHONIA1
DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS1
DRUG INEFFECTIVE1
DRUG EXPOSURE DURING PREGNANCY1
Drug eruption1
DRUG DOSE OMISSION1
DRUG ABUSE1
Dizziness1
DIARRHOEA HAEMORRHAGIC1
Device related infection1
CYTOLYTIC HEPATITIS1
Cutaneous vasculitis1
Clostridium difficile infection1
CLOSTRIDIUM COLITIS1
CLOSTRIDIAL INFECTION1
Chronic lymphocytic leukaemia1
Chills1
Cellulitis1
BURNING SENSATION1
BRONCHOSPASM1
BLISTER1
ATROPHY1
ASPARTATE AMINOTRANSFERASE INCREASED1
ASCITES1
Arthritis infective1
ANOSMIA1
ALANINE AMINOTRANSFERASE INCREASED1
Ageusia1
Acute lymphocytic leukaemia1
Acute kidney injury1
ACCIDENTAL DRUG INTAKE BY CHILD1
Abdominal pain upper1
Abdominal discomfort1
ABASIA1





Toxicity information:

Toxicity class: 6
Toxicity type: N/A
LD50: 10000 mg/kg



External links:

ChEBML: CHEMBL1644
DrugBank: DB01140