Lindane
General information:
| Withdrawn ID: | DB00431 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | P03AB02 |
| Molecular Formula: | C6H6Cl6 |
| Molweight: | 290.83 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1951 |
| First withdrawn: | 2002 |
| Last withdrawn: | 2002 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Lindane as primary suspect: | 16 |
|---|
Reported final outcomes:
| Disability: | 2 |
|---|---|
| Hospitalization (initial or prolonged): | 2 |
| Intervention required to prevent permanent impairment/damage: | 2 |
| Death: | 1 |
| Congenital anomaly: | 1 |
| Life-Threatening condition: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| MEDICATION ERROR | 3 |
| NEUROTOXICITY | 3 |
| COMPLICATIONS OF MATERNAL EXPOSURE TO THERAPEUTIC DRUGS | 1 |
| FATIGUE | 1 |
| DRUG INEFFECTIVE | 1 |
| DISTURBANCE IN ATTENTION | 1 |
| DEPRESSION | 1 |
| DECREASED APPETITE | 1 |
| CONVULSION | 1 |
| CONGENITAL NEUROLOGICAL DISORDER | 1 |
| HEADACHE | 1 |
| CANDIDIASIS | 1 |
| BURNING SENSATION | 1 |
| BREAST CANCER | 1 |
| BRAIN STEM SYNDROME | 1 |
| APPLICATION SITE PRURITUS | 1 |
| ACCIDENTAL EXPOSURE | 1 |
| FEELING ABNORMAL | 1 |
| WRONG TECHNIQUE IN DRUG USAGE PROCESS | 1 |
| HYPOAESTHESIA | 1 |
| JOINT DISLOCATION | 1 |
| LICE INFESTATION | 1 |
| LIVER DISORDER | 1 |
| MENTAL DISORDER DUE TO A GENERAL MEDICAL CONDITION | 1 |
| MUSCLE CONTRACTIONS INVOLUNTARY | 1 |
| MYOCLONUS | 1 |
| PAIN | 1 |
| PREMATURE BABY | 1 |
| PRODUCT QUALITY ISSUE | 1 |
| PRURITUS | 1 |
| RASH | 1 |
| THERAPEUTIC PRODUCT INEFFECTIVE | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P18507 | 4.9 | Gamma-aminobutyric acid receptor subunit gamma-2 | GBRG2_HUMAN |
| P24046 | 91 | Gamma-aminobutyric acid receptor subunit rho-1 | GBRR1_HUMAN |
| P28472 | 0.9 | Gamma-aminobutyric acid receptor subunit beta-3 | GBRB3_HUMAN |
Toxicity information:
| Toxicity class: | 3 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 59 mg/kg |
External links:
| ChEBML: | CHEMBL15891 |
|---|---|
| DrugBank: | DB00431 |