Abarelix


884



General information:


Withdrawn ID: 884
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): L02BX01
Molecular Formula: C72H95ClN14O14
Molweight: 1416.09



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 2003



Side-effects:

Total reported cases (submitted by medical professionals) with Abarelix as primary suspect: 41


Reported final outcomes:
Death: 21
Hospitalization (initial or prolonged): 13
Life-Threatening condition: 6
Intervention required to prevent permanent impairment/damage: 2


Reported side-effects:

Side-effect Case number
DISEASE PROGRESSION6
FLUSHING5
URTICARIA4
DYSPNOEA4
ASTHENIA4
PROSTATIC SPECIFIC ANTIGEN INCREASED3
PROSTATE CANCER3
PALLOR3
HYPOTENSION3
HYPERSENSITIVITY3
HYDRONEPHROSIS3
DIZZINESS3
DIFFICULTY IN WALKING3
DEATH3
COMA3
VENTRICULAR TACHYCARDIA2
URINARY RETENTION2
RESPIRATORY RATE INCREASED2
REFUSAL OF TREATMENT BY PATIENT2
RASH2
PROSTATE CANCER METASTATIC2
PARAESTHESIA2
METASTASES TO SPINE2
METASTASES TO BONE2
MALIGNANT NEOPLASM PROGRESSION2
HYPERHIDROSIS2
HEADACHE2
HAEMOGLOBIN DECREASED2
HAEMATURIA2
HAEMATOCRIT DECREASED2
FEELING HOT2
FALL2
ERYTHEMA2
DIARRHOEA2
DECREASED APPETITE2
CONSTIPATION2
CEREBROVASCULAR ACCIDENT2
CARDIAC FAILURE CONGESTIVE2
BLOOD PRESSURE DECREASED2
ATRIAL FIBRILLATION2
ANAEMIA2
ACUTE MYOCARDIAL INFARCTION2
WHITE BLOOD CELL COUNT INCREASED1
WEIGHT DECREASED1
VISUAL DISTURBANCE1
VENTRICULAR HYPERTROPHY1
UROSEPSIS1
URINARY TRACT INFECTION ENTEROCOCCAL1
URINARY INCONTINENCE1
SYNCOPE VASOVAGAL1
SYNCOPE1
SWELLING FACE1
SWELLING1
STOMATITIS1
SKIN WARM1
SINUS TACHYCARDIA1
SICK SINUS SYNDROME1
RESPIRATORY FAILURE1
RESPIRATORY DISTRESS1
RESPIRATORY ARREST1
RENAL TUBULAR NECROSIS1
RENAL FAILURE ACUTE1
RENAL FAILURE1
RENAL CYST1
RASH PUSTULAR1
RASH PRURITIC1
PYREXIA1
PURULENCE1
PULSE ABSENT1
PRURITUS1
PROTHROMBIN TIME PROLONGED1
PROTEIN TOTAL DECREASED1
PRODUCTIVE COUGH1
PHARYNGITIS STREPTOCOCCAL1
PATHOLOGICAL FRACTURE1
PAIN1
OSTEOARTHRITIS1
OEDEMA PERIPHERAL1
OEDEMA1
NOCTURIA1
NO ADVERSE EFFECT1
NEUTROPHIL COUNT DECREASED1
NEPHROLITHIASIS1
NAUSEA1
MYOCARDIAL INFARCTION1
MYALGIA1
MONOCYTE COUNT INCREASED1
METASTASIS1
METASTASES TO BLADDER1
MELAENA1
LYMPHADENOPATHY1
LUNG INFECTION PSEUDOMONAL1
LUMBAR SPINAL STENOSIS1
LOSS OF CONSCIOUSNESS1
LIVER FUNCTION TEST ABNORMAL1
LETHARGY1
INTERNATIONAL NORMALISED RATIO INCREASED1
INJECTION SITE PAIN1
INJECTION SITE MASS1
INJECTION SITE IRRITATION1
INJECTION SITE BURNING1
INFLUENZA1
INDURATION1
INCOHERENT1
HYPOXIA1
HYPERTENSION1
HYPERKALAEMIA1
HYPERCHOLESTEROLAEMIA1
HERPES ZOSTER1
HEART RATE INCREASED1
GENERAL PHYSICAL HEALTH DETERIORATION1
GASTROOESOPHAGEAL REFLUX DISEASE1
FEMUR FRACTURE1
FATIGUE1
EYE SWELLING1
EXTRAVASATION1
EXTRASYSTOLES1
ELECTROCARDIOGRAM T WAVE INVERSION1
DYSURIA1
DYSARTHRIA1
DIALYSIS1
DEPRESSED LEVEL OF CONSCIOUSNESS1
DEHYDRATION1
CREPITATIONS1
COUGH1
CONFUSIONAL STATE1
CLOSTRIDIAL INFECTION1
CHRONIC OBSTRUCTIVE PULMONARY DISEASE1
CHOLELITHIASIS1
CHEST PAIN1
CATHETER RELATED COMPLICATION1
CARDIOMEGALY1
CARDIAC ARREST1
CARBON DIOXIDE DECREASED1
CANDIDIASIS1
CALCULUS URETERIC1
BRONCHITIS1
BONE PAIN1
BLOOD UREA INCREASED1
BLOOD TESTOSTERONE INCREASED1
BLOOD TESTOSTERONE DECREASED1
BLOOD SODIUM DECREASED1
BLOOD PRESSURE SYSTOLIC INCREASED1
BLOOD PRESSURE INCREASED1
BLOOD PRESSURE DIASTOLIC DECREASED1
BLOOD POTASSIUM INCREASED1
BLOOD PHOSPHORUS INCREASED1
BLOOD GLUCOSE INCREASED1
BLOOD GLUCOSE FLUCTUATION1
BLOOD CREATINE INCREASED1
BLOOD CHLORIDE DECREASED1
BLOOD ALKALINE PHOSPHATASE INCREASED1
BLOOD ALBUMIN DECREASED1
BLADDER DISTENSION1
BENIGN PROSTATIC HYPERPLASIA1
BACTERAEMIA1
BACK PAIN1
ARTHRALGIA1
APPENDICITIS PERFORATED1
APHASIA1
ANOREXIA1





Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 1000 mg/kg



External links:

ChEBML: CHEMBL1252
DrugBank: DB00106