Amprenavir


837



General information:


Withdrawn ID: 837
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): J05AE05
Molecular Formula: C25H35N3O6S
Molweight: 505.627



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1999
First withdrawn: 2004
Last withdrawn: 2004



Side-effects:

Total reported cases (submitted by medical professionals) with Amprenavir as primary suspect: 7


Reported final outcomes:
Hospitalization (initial or prolonged): 1


Reported side-effects:

Side-effect Case number
LIPASE INCREASED1
ACANTHOSIS NIGRICANS1
ASTHENIA1
BLOOD CHOLESTEROL INCREASED1
CD4 LYMPHOCYTES DECREASED1
DEPRESSION1
HEPATOCELLULAR DAMAGE1
HYPERGLYCAEMIA1
INSOMNIA1
INSULIN RESISTANCE1
VIRAL LOAD INCREASED1
LIPODYSTROPHY ACQUIRED1
MUCOSAL ULCERATION1
PARAESTHESIA CIRCUMORAL1
PHARYNX DISCOMFORT1
PRURITUS1
RASH1
RASH MACULO-PAPULAR1
TOXIC SKIN ERUPTION1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P02545 631 Prelamin-A/C LMNA_HUMAN
P24557 6727 Thromboxane-A synthase THAS_HUMAN



Toxicity information:

Toxicity type: N/A



External links:

ChEBML: CHEMBL116
DrugBank: DB00701