Halofantrine
General information:
| Withdrawn ID: | 709 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | P01BX01 |
| Molecular Formula: | C26H30Cl2F3NO |
| Molweight: | 500.424 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1992 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Halofantrine as primary suspect: | 7 |
|---|
Reported final outcomes:
| Death: | 5 |
|---|---|
| Hospitalization (initial or prolonged): | 3 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| TORSADE DE POINTES | 2 |
| THROMBOCYTOPENIA | 2 |
| VENTRICULAR TACHYCARDIA | 2 |
| SUPRAVENTRICULAR TACHYCARDIA | 2 |
| ANAEMIA MACROCYTIC | 2 |
| BLOOD PRESSURE SYSTOLIC DECREASED | 2 |
| CARDIAC ARREST | 2 |
| MALAISE | 2 |
| LOSS OF CONSCIOUSNESS | 2 |
| CARDIAC FAILURE | 2 |
| CIRCULATORY COLLAPSE | 2 |
| ELECTROCARDIOGRAM QT PROLONGED | 2 |
| ABDOMINAL PAIN UPPER | 1 |
| ARRHYTHMIA | 1 |
| CONVULSION | 1 |
| DEATH | 1 |
| DYSPNOEA | 1 |
| EYE MOVEMENT DISORDER | 1 |
| FLATULENCE | 1 |
| FOAMING AT MOUTH | 1 |
| MYOCARDIAL INFARCTION | 1 |
| NAUSEA | 1 |
| RESTLESSNESS | 1 |
| SUDDEN DEATH | 1 |
| SYNCOPE | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| Q12809 | 40 | Potassium voltage-gated channel subfamily H member 2 | KCNH2_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 1932.5 mg/kg |
External links:
| ChEBML: | CHEMBL1107 |
|---|---|
| DrugBank: | DB01218 |