Zalcitabine
General information:
| Withdrawn ID: | 695 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | J05AF03 |
| Molecular Formula: | C9H13N3O3 |
| Molweight: | 211.218 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1992 |
| First withdrawn: | 2006 |
| Last withdrawn: | 2006 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Zalcitabine as primary suspect: | 18 |
|---|
Reported final outcomes:
| Death: | 14 |
|---|---|
| Hospitalization (initial or prolonged): | 4 |
| Disability: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| DEATH | 7 |
| KAPOSI'S SARCOMA | 3 |
| Pyrexia | 3 |
| WEIGHT DECREASED | 2 |
| HEPATITIS C | 2 |
| Hepatotoxicity | 2 |
| DISEASE PROGRESSION | 2 |
| Lymphopenia | 2 |
| MITOCHONDRIAL TOXICITY | 2 |
| Nausea | 2 |
| NEUROPATHY PERIPHERAL | 2 |
| OESOPHAGEAL CANDIDIASIS | 2 |
| Rash | 2 |
| Arthralgia | 1 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 1 |
| FOETAL DISORDER | 1 |
| Fatigue | 1 |
| ABDOMINAL PAIN | 1 |
| AIDS DEMENTIA COMPLEX | 1 |
| FACTOR VIII DEFICIENCY | 1 |
| Eye swelling | 1 |
| AIDS ENCEPHALOPATHY | 1 |
| DRUG EXPOSURE DURING PREGNANCY | 1 |
| DISEASE RECURRENCE | 1 |
| BRONCHITIS | 1 |
| ASPARTATE AMINOTRANSFERASE INCREASED | 1 |
| DIARRHOEA | 1 |
| Aspergillus infection | 1 |
| CYTOMEGALOVIRUS MYOCARDITIS | 1 |
| Asthenia | 1 |
| Back pain | 1 |
| Body height decreased | 1 |
| CONDITION AGGRAVATED | 1 |
| COMA | 1 |
| OESOPHAGEAL ULCER | 1 |
| Vomiting | 1 |
| Toxicity to various agents | 1 |
| THROMBOCYTOPENIA | 1 |
| Stress fracture | 1 |
| PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | 1 |
| PNEUMONIA | 1 |
| Osteoporosis | 1 |
| Osteoarthritis | 1 |
| ORAL CANDIDIASIS | 1 |
| OPTIC NEURITIS | 1 |
| OESOPHAGITIS | 1 |
| GRAND MAL CONVULSION | 1 |
| MYCOBACTERIAL INFECTION | 1 |
| Myalgia | 1 |
| MUSCLE SPASMS | 1 |
| LIVER DISORDER | 1 |
| LEUKOPENIA | 1 |
| LETHARGY | 1 |
| HIV WASTING SYNDROME | 1 |
| HERPES ZOSTER | 1 |
| Headache | 1 |
| HAEMORRHAGE | 1 |
| HAEMATEMESIS | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P02545 | 100 | Prelamin-A/C | LMNA_HUMAN |
| P10636 | 125.9 | Microtubule-associated protein tau | TAU_HUMAN |
| P19838 | 794.3 | Nuclear factor NF-kappa-B p105 subunit | NFKB1_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 5000 mg/kg |
External links:
| ChEBML: | CHEMBL853 |
|---|---|
| DrugBank: | DB00943 |