Ritodrine
General information:
| Withdrawn ID: | 520 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | G02CA01 |
| Molecular Formula: | C17H21NO3 |
| Molweight: | 287.359 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1991 |
| First withdrawn: | 1998 |
| Last withdrawn: | 1998 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Ritodrine as primary suspect: | 13 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 1 |
|---|---|
| Intervention required to prevent permanent impairment/damage: | 1 |
| Disability: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Maternal exposure during pregnancy | 8 |
| Foetal exposure during pregnancy | 4 |
| Premature baby | 4 |
| Low birth weight baby | 3 |
| Pyrexia | 3 |
| Pulmonary hypertension | 3 |
| Premature rupture of membranes | 3 |
| Premature delivery | 3 |
| Amniotic cavity infection | 2 |
| Genital haemorrhage | 1 |
| Hypotension | 1 |
| Funisitis | 1 |
| Dysphagia | 1 |
| Disseminated intravascular coagulation | 1 |
| CARDIAC FAILURE ACUTE | 1 |
| C-reactive protein increased | 1 |
| Bradycardia foetal | 1 |
| Blood beta-D-glucan increased | 1 |
| Bipolar disorder | 1 |
| Attention deficit/hyperactivity disorder | 1 |
| Apgar score low | 1 |
| Apgar score abnormal | 1 |
| Antithrombin III decreased | 1 |
| Antisocial behaviour | 1 |
| Anaphylactoid syndrome of pregnancy | 1 |
| Acute respiratory distress syndrome | 1 |
| Pulmonary oedema | 1 |
| Uterine haemorrhage | 1 |
| Uterine haematoma | 1 |
| Unevaluable event | 1 |
| Suicidal behaviour | 1 |
| Shock haemorrhagic | 1 |
| Sepsis | 1 |
| Salivary gland enlargement | 1 |
| Respiratory distress | 1 |
| Hot flush | 1 |
| Pre-eclampsia | 1 |
| Palpitations | 1 |
| Oropharyngeal discomfort | 1 |
| MYOCARDIAL INFARCTION | 1 |
| Metabolic acidosis | 1 |
| Uterine tenderness | 1 |
| Hyperkalaemia | 1 |
| Hyperamylasaemia | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P07550 | 0.5012 | Beta-2 adrenergic receptor | ADRB2_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 687 mg/kg |
External links:
| ChEBML: | CHEMBL489553 |
|---|---|
| DrugBank: | DB00867 |