Chloroxine
General information:
| Withdrawn ID: | 444 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | J |
| Molecular Formula: | C9H5Cl2NO |
| Molweight: | 214.048 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1976 |
| First withdrawn: | 1990 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Chloroxine as primary suspect: | 1 |
|---|
Reported side-effects:
| Side-effect | Case number |
|---|---|
| EYE IRRITATION | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P00352 | 7079.5 | Retinal dehydrogenase 1 | AL1A1_HUMAN |
| P02545 | 3981.1 | Prelamin-A/C | LMNA_HUMAN |
| P04637 | 3162.3 | Cellular tumor antigen p53 | P53_HUMAN |
| P09917 | 3600 | Polyunsaturated fatty acid 5-lipoxygenase | LOX5_HUMAN |
| P16050 | 2400 | Polyunsaturated fatty acid lipoxygenase ALOX15 | LOX15_HUMAN |
| P18054 | 1000 | Polyunsaturated fatty acid lipoxygenase ALOX12 | LOX12_HUMAN |
| P41145 | 4560 | Kappa-type opioid receptor | OPRK_HUMAN |
| P42858 | 2818.4 | Huntingtin | HD_HUMAN |
| Q9NUW8 | 446.7 | Tyrosyl-DNA phosphodiesterase 1 | TYDP1_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 660 mg/kg |
External links:
| ChEBML: | CHEMBL1200596 |
|---|---|
| DrugBank: | DB01243 |