Probucol
General information:
| Withdrawn ID: | 431 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | C10AX02 |
| Molecular Formula: | C31H48O2S2 |
| Molweight: | 516.842 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1977 |
| First withdrawn: | 1995 |
| Last withdrawn: | 1995 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Probucol as primary suspect: | 2 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 1 |
|---|
Reported side-effects:
| Side-effect | Case number |
|---|---|
| RHABDOMYOLYSIS | 1 |
| Angina unstable | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P05981 | 430 | Serine protease hepsin | HEPS_HUMAN |
| P10636 | 7079.5 | Microtubule-associated protein tau | TAU_HUMAN |
| Q9NXA8 | 1600 | NAD-dependent protein deacylase sirtuin-5, mitochondrial | SIR5_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 5000 mg/kg |
External links:
| ChEBML: | CHEMBL608 |
|---|---|
| DrugBank: | DB01599 |