Mazindol

General information:

Withdrawn ID:	409
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es):	A08AA05
Molecular Formula:	C16H13ClN2O
Molweight:	284.74

Withdrawal information:

Withdrawn due to drug safety reasons:	No
First approved:	1973
First withdrawn:	2008

Side-effects:

Total reported cases (submitted by medical professionals) with Mazindol as primary suspect:	10

Reported final outcomes:

Hospitalization (initial or prolonged):	4

Reported side-effects:

Side-effect	Case number
BIOPSY LIVER ABNORMAL	2
DRUG EXPOSURE DURING PREGNANCY	2
DRUG ERUPTION	2
ERYTHEMA	2
GAMMA-GLUTAMYLTRANSFERASE INCREASED	2
BLOOD BILIRUBIN INCREASED	2
BLOOD ALKALINE PHOSPHATASE INCREASED	2
HEPATIC NECROSIS	2
JAUNDICE	2
LIVER DISORDER	2
ASPARTATE AMINOTRANSFERASE INCREASED	2
ALANINE AMINOTRANSFERASE INCREASED	2
PYREXIA	2
RETINAL HAEMORRHAGE	2
BILIRUBIN CONJUGATED INCREASED	1
EOSINOPHIL COUNT	1
ANOREXIA	1
ANAPHYLACTIC SHOCK	1
BLOOD PRESSURE INCREASED	1
CONDITION AGGRAVATED	1
ABORTION INDUCED	1
Depression	1
Drug abuse	1
ABORTION	1
DRUG INTERACTION	1
Drug reaction with eosinophilia and systemic symptoms	1
DYSPNOEA	1
Weight decreased	1
Face oedema	1
HALLUCINATION	1
HEPATIC ATROPHY	1
HEPATIC FIBROSIS	1
HYPOTENSION	1
Incorrect dose administered	1
LYMPHOCYTIC INFILTRATION	1
NAUSEA	1
OCULAR ICTERUS	1
PRURITUS	1
RASH	1
TACHYCARDIA	1

Filtered ChEMBL targets:

Target UniProtKB ID	Activity in nm	Target Name	Target gene
P23975	0.92	Sodium-dependent noradrenaline transporter	SC6A2_HUMAN
P31645	45	Sodium-dependent serotonin transporter	SC6A4_HUMAN
Q01959	13	Sodium-dependent dopamine transporter	SC6A3_HUMAN

Toxicity information:

Toxicity class:	3
Toxicity type:	N/A
LD50:	300 mg/kg

External links:

ChEBML:	CHEMBL781
DrugBank:	DB00579