Thiabendazole
General information:
| Withdrawn ID: | 361 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | D01AC06 |
| P02CA02 | |
| Molecular Formula: | C10H7N3S |
| Molweight: | 201.248 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1967 |
| First withdrawn: | 1995 |
| Last withdrawn: | 1995 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Thiabendazole as primary suspect: | 14 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 11 |
|---|---|
| Death: | 3 |
| Life-Threatening condition: | 2 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| DRUG INEFFECTIVE | 5 |
| Meningitis | 3 |
| STRONGYLOIDIASIS | 2 |
| INFECTION IN AN IMMUNOCOMPROMISED HOST | 1 |
| LUNG DISORDER | 1 |
| IMPETIGO | 1 |
| HEPATOMEGALY | 1 |
| HEADACHE | 1 |
| ERYTHEMA NODOSUM | 1 |
| EOSINOPHILIA | 1 |
| EOSINOPHIL COUNT INCREASED | 1 |
| ELECTROCARDIOGRAM QT PROLONGED | 1 |
| DRUG ABUSER | 1 |
| DIZZINESS | 1 |
| DISEASE RECURRENCE | 1 |
| DISEASE PROGRESSION | 1 |
| CONVULSION | 1 |
| CONJUNCTIVITIS | 1 |
| BRADYCARDIA | 1 |
| ADVERSE EVENT | 1 |
| PYREXIA | 1 |
| VERTIGO | 1 |
| TOXIC EPIDERMAL NECROLYSIS | 1 |
| THERAPY NON-RESPONDER | 1 |
| STEVENS-JOHNSON SYNDROME | 1 |
| SOMNOLENCE | 1 |
| SKIN ODOUR ABNORMAL | 1 |
| SKIN LESION | 1 |
| RESPIRATORY FAILURE | 1 |
| INFLAMMATION | 1 |
| PNEUMONITIS | 1 |
| OPTIC NEURITIS RETROBULBAR | 1 |
| No therapeutic response | 1 |
| Nausea | 1 |
| MYOCARDIAL INFARCTION | 1 |
| MOUTH ULCERATION | 1 |
| Meningitis bacterial | 1 |
| VOMITING | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O15118 | 3548.1 | NPC intracellular cholesterol transporter 1 | NPC1_HUMAN |
| P04637 | 10000 | Cellular tumor antigen p53 | P53_HUMAN |
| P51151 | 2511.9 | Ras-related protein Rab-9A | RAB9A_HUMAN |
| P53582 | 3400 | Methionine aminopeptidase 1 | MAP11_HUMAN |
| Q16637 | 6309.6 | Survival motor neuron protein | SMN_HUMAN |
| Q16665 | 2511.9 | Hypoxia-inducible factor 1-alpha | HIF1A_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 2200 mg/kg |
External links:
| ChEBML: | CHEMBL625 |
|---|---|
| DrugBank: | DB08630, DB00730 |