Histamine
General information:
| Withdrawn ID: | 3 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | V |
| Molecular Formula: | C5H9N3 |
| Molweight: | 111.145 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1939 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Histamine as primary suspect: | 108 |
|---|
Reported final outcomes:
Reported side-effects:
| Side-effect | Case number |
|---|---|
| False negative investigation result | 90 |
| Drug ineffective | 15 |
| Throat irritation | 1 |
| False positive investigation result | 1 |
| Cough | 1 |
| Anaphylactic reaction | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P02545 | 891.3 | Prelamin-A/C | LMNA_HUMAN |
| P25021 | 114.82 | Histamine H2 receptor | HRH2_HUMAN |
| P35367 | 13 | Histamine H1 receptor | HRH1_HUMAN |
| Q9H3N8 | 1 | Histamine H4 receptor | HRH4_HUMAN |
| Q9Y5N1 | 2.512 | Histamine H3 receptor | HRH3_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 610 mg/kg |
External links:
| ChEBML: | CHEMBL90 |
|---|---|
| DrugBank: |