Thiopental


247



General information:


Withdrawn ID: 247
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N01AF03
N05CA19
Molecular Formula: C11H18N2O2S
Molweight: 242.338



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1982
First withdrawn: 2011
Last withdrawn: 2011



Side-effects:

Total reported cases (submitted by medical professionals) with Thiopental as primary suspect: 129


Reported final outcomes:
Intervention required to prevent permanent impairment/damage: 81
Hospitalization (initial or prolonged): 16
Life-Threatening condition: 14
Death: 7
Disability: 2
Congenital anomaly: 1


Reported side-effects:

Side-effect Case number
HYPOTENSION28
LUNG INFILTRATION14
ANAESTHETIC COMPLICATION11
PNEUMONIA10
TACHYCARDIA9
PLEURAL EFFUSION9
CARDIAC ARREST8
ANAPHYLACTIC REACTION7
OXYGEN SATURATION DECREASED5
ERYTHEMA5
DRUG INEFFECTIVE5
BRONCHOSPASM5
BLOOD PRESSURE DECREASED5
HEPATIC FUNCTION ABNORMAL4
DRUG INTERACTION4
BRADYCARDIA4
ALANINE AMINOTRANSFERASE INCREASED4
RESPIRATORY DISORDER3
DRUG EFFECT DECREASED3
COMA3
CIRCULATORY COLLAPSE3
ASPARTATE AMINOTRANSFERASE INCREASED3
WRONG TECHNIQUE IN DRUG USAGE PROCESS2
VENTRICULAR TACHYCARDIA2
UNWANTED AWARENESS DURING ANAESTHESIA2
SOMNOLENCE2
SEPSIS2
RASH2
PROCEDURAL PAIN2
PREMATURE RECOVERY FROM ANAESTHESIA2
POST PROCEDURAL COMPLICATION2
PHARMACEUTICAL PRODUCT COMPLAINT2
PERITONEAL DIALYSIS2
PAROTID GLAND ENLARGEMENT2
OVERDOSE2
NEUTROPENIA2
HYPOXIA2
HYPOTONIA2
HYPOKALAEMIA2
HYPERSENSITIVITY2
HYPERKALAEMIA2
HAEMODYNAMIC INSTABILITY2
GENERALISED ERYTHEMA2
FLUSHING2
DRUG EXPOSURE DURING PREGNANCY2
CYTOLYTIC HEPATITIS2
CONDITION AGGRAVATED2
CEREBRAL ISCHAEMIA2
BRAIN OEDEMA2
WRONG DRUG ADMINISTERED1
VENTRICULAR HYPOKINESIA1
VENTRICULAR FIBRILLATION1
VENTRICULAR EXTRASYSTOLES1
VASOCONSTRICTION1
Vascular compression1
UTERINE ENLARGEMENT1
URINARY TRACT INFECTION1
URINARY INCONTINENCE1
TUMOUR LYSIS SYNDROME1
TORSADE DE POINTES1
THROMBOCYTOPENIA1
THERAPEUTIC RESPONSE DELAYED1
SUPRAVENTRICULAR EXTRASYSTOLES1
SUICIDE ATTEMPT1
SUBDURAL HAEMATOMA1
STILLBIRTH1
STATUS EPILEPTICUS1
SPEECH DISORDER1
SPASTIC PARALYSIS1
SKIN SWELLING1
SKIN DISCOLOURATION1
SEPTIC SHOCK1
RESPIRATORY DISTRESS1
RENAL TUBULAR NECROSIS1
RENAL IMPAIRMENT1
RENAL DISORDER1
REFUSAL OF TREATMENT BY RELATIVE1
RASH PAPULAR1
PYREXIA1
PULSE ABSENT1
PULMONARY OEDEMA1
PROTHROMBIN LEVEL DECREASED1
PROCEDURAL COMPLICATION1
POST PROCEDURAL NAUSEA1
POOR PERIPHERAL CIRCULATION1
PO2 DECREASED1
Platelet count decreased1
PHARYNGEAL OEDEMA1
PAROTITIS1
PALLOR1
OPERATIVE HAEMORRHAGE1
OFF LABEL USE1
OBSTRUCTIVE AIRWAYS DISORDER1
NO THERAPEUTIC RESPONSE1
Nausea1
MUSCLE RIGIDITY1
MULTI-ORGAN DISORDER1
MOVEMENT DISORDER1
METABOLIC ACIDOSIS1
Maternal exposure during pregnancy1
MATERNAL DRUGS AFFECTING FOETUS1
LUNG DISORDER1
LOCALISED OEDEMA1
LIVER DISORDER1
LISTLESS1
LIP BLISTER1
LIFE SUPPORT1
LABILE BLOOD PRESSURE1
INTRACRANIAL PRESSURE INCREASED1
INTESTINAL ISCHAEMIA1
INJECTION SITE URTICARIA1
INFECTION1
ILEUS PARALYTIC1
HYPOVENTILATION1
HYPOTHERMIA1
HYPONATRAEMIA1
HEPATITIS ACUTE1
HEPATIC FAILURE1
HEPATIC ENCEPHALOPATHY1
HEART RATE INCREASED1
HEART RATE DECREASED1
HAEMODIALYSIS1
GASTROINTESTINAL NECROSIS1
FLUID RETENTION1
FLUID OVERLOAD1
FEBRILE NEUTROPENIA1
FALSE NEGATIVE LABORATORY RESULT1
FAECAL INCONTINENCE1
FACE OEDEMA1
EYELID OEDEMA1
ENDOMETRIAL CANCER1
ELECTROENCEPHALOGRAM ABNORMAL1
ELECTROCARDIOGRAM ST-T CHANGE1
DYSGEUSIA1
DRUG RESISTANCE1
DEPRESSED LEVEL OF CONSCIOUSNESS1
DEMENTIA1
DECREASED EYE CONTACT1
CREUTZFELDT-JAKOB DISEASE1
CORTICAL LAMINAR NECROSIS1
CONVULSION1
CONTRAINDICATION TO MEDICAL TREATMENT1
COMPUTERISED TOMOGRAM ABNORMAL1
COAGULATION FACTOR V LEVEL DECREASED1
CHOLESTASIS1
CEREBROVASCULAR ACCIDENT1
CEREBRAL HAEMORRHAGE1
CEREBRAL ATROPHY1
CENTRAL NERVOUS SYSTEM LESION1
CARDIOVASCULAR DISORDER1
Cardiogenic shock1
CAESAREAN SECTION1
BRONCHIAL OBSTRUCTION1
Bronchial disorder1
Breath sounds absent1
BLOOD PRESSURE INCREASED1
BLOOD POTASSIUM INCREASED1
Blood lactate dehydrogenase increased1
Blood bilirubin increased1
BLISTER1
ATRIAL FIBRILLATION1
ASPIRATION1
ARRHYTHMIA1
APHASIA1
APGAR SCORE LOW1
APALLIC SYNDROME1
ANTIPSYCHOTIC DRUG LEVEL INCREASED1
ANAPHYLACTIC SHOCK1
ANAESTHETIC COMPLICATION FOETAL1
AGRANULOCYTOSIS1
AGGRESSION1
Abdominal tenderness1
ABDOMINAL ABSCESS1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P02545 354.8 Prelamin-A/C LMNA_HUMAN



Toxicity information:

Toxicity class: 3
Toxicity type: N/A
LD50: 180 mg/kg



External links:

ChEBML: CHEMBL441
DrugBank: DB00599