Mecamylamine
General information:
| Withdrawn ID: | 181 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | C02BB01 |
| Molecular Formula: | C11H21N |
| Molweight: | 167.291 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1950 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Mecamylamine as primary suspect: | 4 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 2 |
|---|
Reported side-effects:
| Side-effect | Case number |
|---|---|
| Wound | 1 |
| Urinary tract infection | 1 |
| Muscle twitching | 1 |
| Hospitalisation | 1 |
| Dyskinesia | 1 |
| Drug ineffective | 1 |
| Aggression | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P14618 | 10 | Pyruvate kinase PKM | KPYM_HUMAN |
| P19838 | 3162.3 | Nuclear factor NF-kappa-B p105 subunit | NFKB1_HUMAN |
| P30926 | 700 | Neuronal acetylcholine receptor subunit beta-4 | ACHB4_HUMAN |
| P36544 | 1800 | Neuronal acetylcholine receptor subunit alpha-7 | ACHA7_HUMAN |
| P40225 | 10000 | Thrombopoietin | TPO_HUMAN |
| Q15822 | 3100 | Neuronal acetylcholine receptor subunit alpha-2 | ACHA2_HUMAN |
Toxicity information:
| Toxicity class: | 3 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 138 mg/kg |
External links:
| ChEBML: | CHEMBL267936 |
|---|---|
| DrugBank: | DB00657 |