Hydrocortisone cypionate


1327



General information:


Withdrawn ID: 1327
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A01AC03
A07EA02
C05AA01
D07AA02
D07XA01
H02AB09
S01BA02
S01CB03
S02BA01
Molecular Formula: C29H42O6
Molweight: 486.65



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1955



Side-effects:

Total reported cases (submitted by medical professionals) with Hydrocortisone cypionate as primary suspect: 94


Reported final outcomes:
Hospitalization (initial or prolonged): 13
Death: 2
Disability: 2


Reported side-effects:

Side-effect Case number
DRUG INEFFECTIVE13
FATIGUE11
MALAISE8
Weight increased8
Drug dose omission6
DRUG HYPERSENSITIVITY6
VOMITING6
ADRENOCORTICAL INSUFFICIENCY ACUTE5
HEADACHE5
Nausea5
PAIN5
WEIGHT DECREASED5
FEELING ABNORMAL4
PYREXIA4
ABDOMINAL DISCOMFORT3
ABDOMINAL PAIN UPPER3
ADRENAL INSUFFICIENCY3
Arthralgia3
Cushingoid3
DEHYDRATION3
DIARRHOEA3
DRUG EFFECT DECREASED3
Drug interaction3
Dyspnoea3
GASTROINTESTINAL DISORDER3
HYPOGLYCAEMIA3
NASOPHARYNGITIS3
Product quality issue3
SOMNOLENCE3
SWELLING FACE3
Wrong technique in product usage process3
AGITATION2
AMNESIA2
ANXIETY2
Asthma2
CONDITION AGGRAVATED2
CONVULSION2
Cortisol decreased2
DIZZINESS2
Drug intolerance2
Dry mouth2
DYSGEUSIA2
FLUID RETENTION2
GASTROENTERITIS2
HYPERHIDROSIS2
Hyponatraemia2
HYPOTENSION2
INCORRECT DOSE ADMINISTERED2
Intentional product misuse2
Intentional product use issue2
Lethargy2
Loss of personal independence in daily activities2
MEDICATION ERROR2
MIGRAINE2
MUSCLE SPASMS2
MYALGIA2
PALPITATIONS2
Peripheral swelling2
PHARMACEUTICAL PRODUCT COMPLAINT2
Pneumonia2
Product substitution issue2
Product use in unapproved indication2
Product use issue2
RASH2
SWELLING2
URTICARIA2
Wheezing2
ABDOMINAL SEPSIS1
ACUTE ABDOMEN1
Addison's disease1
Adrenal disorder1
ADRENOCORTICAL INSUFFICIENCY CHRONIC1
Aggression1
ANGINA PECTORIS1
APHASIA1
ARTHRITIS BACTERIAL1
ASTHENIA1
Back pain1
BLINDNESS1
BLOOD CHOLESTEROL INCREASED1
Blood glucose decreased1
Blood glucose increased1
Blood pressure diastolic increased1
Blood pressure fluctuation1
BLOOD TESTOSTERONE DECREASED1
Body mass index increased1
Body temperature decreased1
Bone loss1
BREAST CANCER1
Breast cancer stage III1
CARDIAC DEATH1
CARDIAC FAILURE1
Cataract1
Cerebrovascular accident1
Chills1
Colitis ulcerative1
COLONIC STENOSIS1
CONFUSIONAL STATE1
Cushing's syndrome1
CYST1
Decreased appetite1
DEPRESSED LEVEL OF CONSCIOUSNESS1
DIABETES INSIPIDUS1
Disease recurrence1
Drug dependence1
DRUG DISPENSING ERROR1
Drug effect delayed1
Drug screen negative1
Emphysema1
Erythema1
Excessive skin1
Eye disorder1
Fall1
Food allergy1
Frequent bowel movements1
Gait disturbance1
GASTRITIS1
GASTROOESOPHAGEAL REFLUX DISEASE1
Genital swelling1
Growth hormone deficiency1
HAEMATEMESIS1
HAEMOGLOBIN INCREASED1
Head injury1
Heart rate decreased1
Hormone level abnormal1
Hot flush1
HYPERKALAEMIA1
Hypersensitivity1
HYPERTENSION1
Hypocalcaemia1
Hypoglycaemic seizure1
Hypokalaemia1
HYPOTHYROIDISM1
Immunodeficiency1
Immunosuppression1
Infusion related reaction1
Injection site extravasation1
Insomnia1
Intentional underdose1
Joint swelling1
Labile blood pressure1
Laboratory test abnormal1
LARGE INTESTINE PERFORATION1
Leukocytosis1
Lipohypertrophy1
LOSS OF CONSCIOUSNESS1
MALABSORPTION1
MENINGITIS BACTERIAL1
Mental impairment1
MOBILITY DECREASED1
MUCOSAL ULCERATION1
Muscular weakness1
Musculoskeletal stiffness1
MYDRIASIS1
Myocardial infarction1
Neoplasm1
Neoplasm malignant1
NERVOUS SYSTEM DISORDER1
Neuropathy peripheral1
NEUTROPHIL COUNT INCREASED1
Oedema1
Oral discomfort1
Osteoarthritis1
Pallor1
Petechiae1
Pituitary tumour1
Pituitary tumour benign1
Pituitary-dependent Cushing's syndrome1
PLATELET COUNT DECREASED1
PNEUMOPERITONEUM1
POOR QUALITY DRUG ADMINISTERED1
Poor quality product administered1
Prescribed overdose1
Product appearance confusion1
Product contamination physical1
Product dispensing error1
Product dose omission issue1
PRODUCT ODOUR ABNORMAL1
Product physical issue1
PRODUCT SIZE ISSUE1
PRODUCT TASTE ABNORMAL1
Productive cough1
PRURITUS1
Pulmonary oedema1
Purpura1
Reaction to excipient1
Respiratory disorder1
Respiratory rate increased1
Rheumatoid arthritis1
Road traffic accident1
Solar lentigo1
Speech disorder1
Sputum discoloured1
SQUAMOUS CELL CARCINOMA1
Steroid withdrawal syndrome1
Stress1
SYNCOPE1
TABLET PHYSICAL ISSUE1
Tachycardia1
Therapeutic product effect decreased1
Therapeutic response unexpected1
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION1
Therapy change1
THYROID FUNCTION TEST ABNORMAL1
Tooth disorder1
Tremor1
Tumour flare1
Urine output increased1
Vertigo1
VIRAL SKIN INFECTION1
Visual impairment1
WHITE BLOOD CELL COUNT DECREASED1
Wrong technique in drug usage process1





Toxicity information:

Toxicity class: 5
Toxicity type: N/A
LD50: 3267 mg/kg



External links:

ChEBML: CHEMBL1549
DrugBank: DB00741