Methysergide
General information:
| Withdrawn ID: | 1219 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | N02CA04 |
| Molecular Formula: | C21H27N3O2 |
| Molweight: | 353.458 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1962 |
| First withdrawn: | 2014 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Methysergide as primary suspect: | 10 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 6 |
|---|---|
| Disability: | 2 |
| Life-Threatening condition: | 1 |
| Death: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| MITRAL VALVE INCOMPETENCE | 3 |
| HEADACHE | 2 |
| Tricuspid valve incompetence | 2 |
| SURGERY | 2 |
| Cardiac valve disease | 2 |
| RETROPERITONEAL FIBROSIS | 2 |
| COMPUTERISED TOMOGRAM ABNORMAL | 1 |
| FIBROSIS | 1 |
| FEMORAL ARTERY OCCLUSION | 1 |
| EJECTION FRACTION DECREASED | 1 |
| Dyspnoea exertional | 1 |
| DYSPNOEA | 1 |
| Drug effect decreased | 1 |
| DRUG DEPENDENCE | 1 |
| Drug abuse | 1 |
| Dilatation atrial | 1 |
| CYANOSIS | 1 |
| CREATININE RENAL CLEARANCE DECREASED | 1 |
| JUGULAR VEIN DISTENSION | 1 |
| COLORECTAL CANCER RECURRENT | 1 |
| CAROTID ARTERY ATHEROMA | 1 |
| CARDIO-RESPIRATORY ARREST | 1 |
| CARDIAC PACEMAKER REMOVAL | 1 |
| CARDIAC PACEMAKER INSERTION | 1 |
| Brain natriuretic peptide increased | 1 |
| Aortic valve incompetence | 1 |
| ACUTE MYOCARDIAL INFARCTION | 1 |
| PEPTIC ULCER HAEMORRHAGE | 1 |
| VEIN DISORDER | 1 |
| VASCULAR BYPASS GRAFT | 1 |
| Tricuspid valve disease | 1 |
| SWELLING FACE | 1 |
| SUPERIOR VENA CAVAL OCCLUSION | 1 |
| Right ventricular failure | 1 |
| RENAL IMPAIRMENT | 1 |
| Pulmonary arterial pressure increased | 1 |
| Pulmonary arterial pressure abnormal | 1 |
| Pulmonary arterial hypertension | 1 |
| PERIARTHRITIS | 1 |
| Heart valve replacement | 1 |
| PELVIC FIBROSIS | 1 |
| Palpitations | 1 |
| OESOPHAGEAL STENT INSERTION | 1 |
| OEDEMA PERIPHERAL | 1 |
| MULTI-ORGAN FAILURE | 1 |
| Mitral valve stenosis | 1 |
| Mitral valve disease | 1 |
| Migraine | 1 |
| VENOUS OPERATION | 1 |
| INTENTIONAL DRUG MISUSE | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| P00352 | 3162.3 | Retinal dehydrogenase 1 | AL1A1_HUMAN |
| P28223 | 10 | 5-hydroxytryptamine receptor 2A | 5HT2A_HUMAN |
| P28335 | 2.5 | 5-hydroxytryptamine receptor 2C | 5HT2C_HUMAN |
| P41595 | 7.586 | 5-hydroxytryptamine receptor 2B | 5HT2B_HUMAN |
Toxicity information:
| Toxicity class: | 3 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 200 mg/kg |
External links:
| ChEBML: | CHEMBL1065 |
|---|---|
| DrugBank: | DB00247 |