Trichlormethiazide
General information:
| Withdrawn ID: | 1126 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | C03AA06 |
| Molecular Formula: | C8H8Cl3N3O4S2 |
| Molweight: | 380.656 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1960 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Trichlormethiazide as primary suspect: | 6 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 5 |
|---|
Reported side-effects:
| Side-effect | Case number |
|---|---|
| DEHYDRATION | 2 |
| Hypotension | 1 |
| ACUTE LEUKAEMIA | 1 |
| ALANINE AMINOTRANSFERASE INCREASED | 1 |
| ASPARTATE AMINOTRANSFERASE INCREASED | 1 |
| BLOOD UREA INCREASED | 1 |
| CHRONIC SINUSITIS | 1 |
| DECREASED APPETITE | 1 |
| Fall | 1 |
| FALSE POSITIVE LABORATORY RESULT | 1 |
| Femoral neck fracture | 1 |
| HAEMATURIA | 1 |
| HYPERCALCAEMIA | 1 |
| TOXIC SKIN ERUPTION | 1 |
| INTERSTITIAL LUNG DISEASE | 1 |
| INTESTINAL HYPOMOTILITY | 1 |
| LACUNAR INFARCTION | 1 |
| LIVER DISORDER | 1 |
| LYMPHOCYTE STIMULATION TEST POSITIVE | 1 |
| MALAISE | 1 |
| MENIERE'S DISEASE | 1 |
| MUSCULAR WEAKNESS | 1 |
| Oedema peripheral | 1 |
| PLATELET COUNT DECREASED | 1 |
| PSORIASIS | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O43570 | 312 | Carbonic anhydrase 12 | CAH12_HUMAN |
| P00915 | 345 | Carbonic anhydrase 1 | CAH1_HUMAN |
| P00918 | 91 | Carbonic anhydrase 2 | CAH2_HUMAN |
| P22748 | 449 | Carbonic anhydrase 4 | CAH4_HUMAN |
| P23280 | 2459 | Carbonic anhydrase 6 | CAH6_HUMAN |
| P35218 | 763 | Carbonic anhydrase 5A, mitochondrial | CAH5A_HUMAN |
| P43166 | 7.9 | Carbonic anhydrase 7 | CAH7_HUMAN |
| Q16790 | 87 | Carbonic anhydrase 9 | CAH9_HUMAN |
| Q9ULX7 | 3450 | Carbonic anhydrase 14 | CAH14_HUMAN |
| Q9Y2D0 | 134 | Carbonic anhydrase 5B, mitochondrial | CAH5B_HUMAN |
Toxicity information:
| Toxicity class: | 5 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 2600 mg/kg |
External links:
| ChEBML: | CHEMBL1054 |
|---|---|
| DrugBank: | DB01021 |