Digitoxin
General information:
| Withdrawn ID: | 1083 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | C01AA04 |
| Molecular Formula: | C41H64O13 |
| Molweight: | 764.939 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | No |
|---|---|
| First approved: | 1982 |
Side-effects:
| Total reported cases (submitted by medical professionals) with Digitoxin as primary suspect: | 3 |
|---|
Reported final outcomes:
| Hospitalization (initial or prolonged): | 3 |
|---|---|
| Life-Threatening condition: | 1 |
| Death: | 1 |
Reported side-effects:
| Side-effect | Case number |
|---|---|
| SYNCOPE | 2 |
| BRADYCARDIA | 2 |
| DRUG INTERACTION | 2 |
| Hyperkalaemia | 1 |
| Acute kidney injury | 1 |
| Arrhythmia | 1 |
| ATRIAL FIBRILLATION | 1 |
| Condition aggravated | 1 |
| General physical health deterioration | 1 |
| HEART RATE DECREASED | 1 |
| VOMITING | 1 |
| Intraventricular haemorrhage | 1 |
| LOSS OF CONSCIOUSNESS | 1 |
| Palpitations | 1 |
| Product monitoring error | 1 |
| Tachycardia | 1 |
| Ventricular arrhythmia | 1 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O15118 | 251.2 | NPC intracellular cholesterol transporter 1 | NPC1_HUMAN |
| P02545 | 707.9 | Prelamin-A/C | LMNA_HUMAN |
| P04637 | 31.6 | Cellular tumor antigen p53 | P53_HUMAN |
| P10636 | 7079.5 | Microtubule-associated protein tau | TAU_HUMAN |
| P40763 | 700 | Signal transducer and activator of transcription 3 | STAT3_HUMAN |
| P51151 | 223.9 | Ras-related protein Rab-9A | RAB9A_HUMAN |
Toxicity information:
| Toxicity class: | 2 |
|---|---|
| Toxicity type: | N/A |
| LD50: | 8.3 mg/kg |
External links:
| ChEBML: | CHEMBL254219 |
|---|---|
| DrugBank: | DB01396 |