Post-marketing drug withdrawals can be associated with
various events, ranging from safety issues such as reported
deaths or severe side-effects, to a multitude of non-safety
problems including lack of efficacy, manufacturing, regulatory
or business issues. During the last century, the majority of drugs
voluntarily withdrawn from the market or prohibited by regulatory
agencies was reported to be related to adverse drug reactions.
Understanding the underlying mechanisms that lead to the withdrawal
of a substance is of utmost importance for current and future drug discovery.
The Withdrawn database aims to facilitate this by not only listing
withdrawal information, but also important features such as toxicity
information, side-effects, targets, ATC classes and more.
If you have any questions please see the FAQs or feel free to contact us!
To easily find specific withdrawn drugs or browse the whole database,
a number of different access points are available.
If you're looking for a specific withdrawn drug, you can directly access the information page via withdrawn id or drug name.
Additionally, you can search for withdrawn drugs that have a similar chemical structure as an input structure, or contain a specific substructure.
For a quick overview over all withdrawn drugs contained in the database, the browse tab lists them sorted by name.
For a more systematic approach, an ATC tree of all withdrawn drugs that have an ATC code assigned is available.
Lastly, if you are interested in a specific protein class or target, a target search is available to find out if, and if yes, which withdrawn drugs are associated with the target(s) of interest.
As a starting point for investigation about drug withdrawals, a mechanism of action and pathway enrichment analysis are available. Both work via structural similarity searches of withdrawn drugs to known ChEMBL compounds, and display target acitivies and KEGG pathways with druggable targets respectively.