Enzyme - Results


CYP: 2C19



Information Structure
Name 2C19
Synonyms
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, Mephenytoin 4-hydroxylase, CP2CJ
UniProt ID cp2cj_human
Accession Number P33259
P33261
Q8WZB1
Q8WZB2
Q9UCD4
EC Number1.14.13.48
1.14.13.49
1.14.13.80
Drug Interactions
NameRelationReferences
Acetylsalicylic AcidInducer 12621391,
12621391,
AdinazolamSubstrate 9600717,
9600717,
AminogluthetimideInducer Umm
AminophenazoneInhibitor,Substrate 11853173,
10199594
AmiodaroneSubstrate 11038157,
AmitriptylineInhibitor,Substrate Umm
AmoxicillinSubstrate 11240980,
14696516,
12121503,
12731459,
16
AmprenavirInhibitor Umm
11996015,
AprepitantInhibitor,Substrate Umm
15304427,
ArtemetherSubstrate 9842988
ArtemisininInducer 10626755,
11432537,
11432537,
10626755,
AtomoxetineSubstrate Umm
AzelastineSubstrate,Inhibitor Umm
10421623,
BarnidipineInhibitor 10805063,
10805063,
BenidipineInhibitor 10805063,
10805063,
BenzatropineSubstrate 17003230
BenzethoniumSubstrate 17003230
BenzydamineSubstrate 11531003,
11012553,
BicalutamideInhibitor 15509184
BifonazoleInhibitor PMID: 2634093
BortezomibInhibitor,Substrate Umm
BromazepamSubstrate 9435993
BrompheniramineSubstrate Umm
BuflomedilSubstrate 10909680,
11996015,
BupivacaineSubstrate Umm
10725304,
BuprenorphineInhibitor Umm
CapsaicinSubstrate 12641434,
CarbamazepineInducer,Inhibitor Medicine.iupui.edu/flockhart
11996015,
CarbinoxamineSubstrate Umm
CarisoprodolSubstrate 12835613,
12835613,
ChininInhibitor,Substrate 9088578
ChloramphenicolInhibitor,Substrate 14576103,
14576103,
ChlormadinoneInhibitor
ChloroformSubstrate 11996015,
ChlorpropamideSubstrate 15842554,
15842554,
CiclosporinInhibitor 17202802
CilostazolSubstrate Umm
CimetidineInhibitor Umm
11334262,
11067738,
16276979,
CisaprideSubstrate 10859153,
10780971,
CitalopramInhibitor,Substrate Umm
10494454,
ClarithromycinInhibitor,Substrate 15952098,
ClobazamSubstrate 12451290,
15533655,
15483195,
14729419,
ClomethiazoleSubstrate 11996015,
ClomipramineSubstrate 15199661,
11763000,
8667235,
15199661,
ClopidogrelSubstrate 17361128
ClotiazepamSubstrate 16141545,
ClotrimazoleInhibitor Umm
ClozapineInhibitor,Substrate 10422890,
10422890,
8866916,
ColecalciferolInhibitor 10219964,
CyclophosphamideSubstrate 16550168,
9241661,
10348794,
8242617,
9010702,
9331082,
DapsoneSubstrate Umm
10901692,
DelavirdineInhibitor 11124228,
Umm
11124228,
11225565,
DesipramineSubstrate,Inhibitor 9884317,
DesloratadineInhibitor 11502723
DesogestrelSubstrate 9864282,
9864282,
DexamethasoneInducer 12869636
DexfenfluramineInhibitor 9825834,
DextromethorphanSubstrate Umm
9113345,
9811160,
DiazepamInhibitor,Substrate Umm
11996015,
DiclofenacSubstrate Umm
10449188,
10572000,
DiethyltoluamideSubstrate 11854147,
Dimethyl SulfoxideInhibitor 9929510
DopamineSubstrate 10813809
DoxazosinSubstrate Https://www.pfizerpro.com/product_info/cardura_xl_pi_clinical_pharmacology.jsp
DoxepinSubstrate 12180536,
12180536,
12360109,
DronabinolSubstrate 7487078,
1352216,
8730919,
EfavirenzInhibitor 15983905,
Umm
11225565,
EntacaponeInhibitor Umm
EscitalopramSubstrate 15057659
EsomeprazoleSubstrate 16961157,
Umm
EstradiolSubstrate 11741520,
11067738,
EthanolInhibitor 9929510,
EthinylestradiolInhibitor,Substrate Umm
12895199,
EthotoinInhibitor Umm
2879902,
EtizolamSubstrate 17635335
EtoricoxibInhibitor 11353749
FamotidineSubstrate 17112810
FelbamateInhibitor 9606477,
Umm
15038401,
9606477,
FenofibrateInhibitor Umm
FluconazoleInhibitor 10709776,
Umm
10709776,
11475469,
FlunitrazepamSubstrate 12640218,
11159802,
12640218,
11259331,
10574680,
10574680,
FluoxetineSubstrate,Inhibitor 11730569,
Umm
10997938,
FlutamideSubstrate 17403914
FluvoxamineInhibitor 12452751,
17596106,
Umm
15199661,
12695344,
FormoterolSubstrate Drugbank
FosamprenavirInhibitor Umm
FosphenytoinInhibitor,Substrate Umm
GefitinibInhibitor Umm
GemfibrozilInhibitor 11602509
GlibenclamideSubstrate 16198656,
11956508,
GliclazideInhibitor 17298483
GlipizideSubstrate 10208645
GlucosamineSubstrate 11531003
HaloperidolSubstrate 11717183,
HexobarbitalSubstrate 17487889
IbuprofenSubstrate Umm
11038161,
11996015,
IfosfamideSubstrate Umm
10348794,
ImatinibSubstrate Umm
ImipramineInhibitor,Substrate 11996015,
IndinavirInhibitor Umm
9549640,
11996015,
IndometacinInhibitor,Substrate Umm
IpriflavoneInhibitor 17624023
IsoniazidInhibitor Umm
11158730,
15528841,
IsopropanolInhibitor 11996015,
KetobemidoneSubstrate 16278191
KetoconazoleInhibitor 14709627,
10192828,
10383565,
15618748,
LafutidineInhibitor 14653835
LansoprazoleSubstrate,Inhibitor 15496639,
8627562,
12975331,
15301728,
8627562,
15752376,
15496639,
12612455,
LopinavirInhibitor 12724045
LoratadineInducer,Inhibitor Umm
LosartanInhibitor Umm
10877007,
LumiracoxibSubstrate 16372823,
LynestrenolInducer,Substrate 18356043
MedazepamSubstrate 18175099
MedrysoneInhibitor 16476124
MelatoninSubstrate 17003850,
11270913,
10877005,
MemantineInhibitor 15378224,
15378224,
MephenytoinInhibitor,Substrate 9131945,
MeprobamateSubstrate 12835613
MesuximideInhibitor,Substrate 7640152,
2879902,
MethadoneSubstrate 12900870
MethazolamideInhibitor 14739663
MethylphenobarbitalInhibitor,Substrate 2879902,
7640152,
MetoprololSubstrate 11996015,
MiconazoleInhibitor 16141567,
11854151,
16141567,
MoclobemideSubstrate,Inhibitor Medicine.iupui.edu/flockhart
7781267,
9265947,
11309556,
ModafinilInducer,Inhibitor 10820139
NelfinavirInhibitor,Substrate 9660842,
NicardipineInhibitor 15863898,
10805063,
NicotineSubstrate 10350185,
NilutamideInhibitor,Substrate 1785203,
1785203,
NilvadipineInhibitor 14993813,
NordazepamSubstrate 8904619,
10613621,
8948091,
NorethisteroneInducer Medicine.iupui.edu/flockhart
NortriptylineSubstrate 9867310,
9193876,
NoscapineInhibitor 20668444
OlanzapineInhibitor 8866916,
OmeprazoleInducer,Inhibitor,Substrate 10626755
Orphenadrine (citrate)Inhibitor 9172960,
OxcarbazepineInhibitor 12895138,
12458024,
15038401,
12458024,
PantoprazoleInhibitor,Substrate 9433390
ParoxetineInhibitor 11910269
PentobarbitalSubstrate 10805060
PerazineInhibitor,Substrate 11026737,
PerphenazineSubstrate Umm
11136295,
PethidineSubstrate 15319333,
15319333,
PhenacetinSubstrate 10421611,
10548449,
PhenazoneInhibitor,Substrate 9172960
PhenelzineInhibitor,Substrate 16669850
PhenobarbitalInducer,Substrate 12642468,
PhensuximideInhibitor 2879902,
PhenytoinInducer,Substrate Umm
11996015,
PimozideInhibitor Umm
PioglitazoneInhibitor Umm
PodophyllotoxinSubstrate 18050240,
PraziquantelSubstrate 12920490,
PrimidoneInducer,Substrate 10380060
ProbenecidInhibitor 710028
ProgesteroneInhibitor,Substrate 9328296,
ProguanilSubstrate 12222994,
Medicine.iupui.edu/flockhart
10417492,
10411572,
11501186,
12451432,
PromazineSubstrate 12721102,
12721102,
PropofolSubstrate Umm
9771309,
PropranololSubstrate 11038161,
10411572,
11038161,
QuazepamSubstrate 15801544,
QuetiapineSubstrate 15516294,
RabeprazoleInhibitor,Substrate 16487224,
15258107,
15903128,
RanitidineSubstrate Umm
11128045,
Retinol (vit A)Inhibitor 10219964,
10219964,
RifampicinSubstrate,Inducer 11735605,
12426514,
9489590
RitonavirInducer,Inhibitor 9549640,
9812178,
9812178,
RosiglitazoneInhibitor 12642470
SaquinavirInhibitor Umm
9549640,
SelegilineSubstrate 11602525,
11417445,
11602525,
12920164,
SeratrodastInhibitor,Substrate 9010637,
SertralineSubstrate,Inhibitor 11420570,
12143142,
11452243,
9808080,
8667235,
8861776,
15547048,
SildenafilInhibitor,Substrate Umm
SulconazoleInhibitor 11854151,
11854151,
SulfanilamideInhibitor 14739663
TamoxifenSubstrate 16550168
TelmisartanInhibitor Umm
TemazepamSubstrate Umm
8948091,
TeniposideSubstrate Medicine.iupui.edu/flockhart
TerbinafineSubstrate 10460803,
10460803,
TestosteroneSubstrate 9328296,
16501008,
9328296,
TetrabenazineInducer 15232626
ThalidomideSubstrate 12060642,
12060642,
12642692,
ThiamazoleInhibitor 9172960,
9172960,
ThioridazineSubstrate Umm
TiclopidineInhibitor 9390115,
10233213,
11580286,
9390115,
10497136,
11764927,
11580286,
11372587,
10233213,
14977868,
10759690,
12721102,
TimololSubstrate 17431033
TioconazoleInhibitor 11854151,
11854151,
TolbutamideSubstrate Umm
10681382,
7487078,
TolperisoneSubstrate 12695352,
12695352,
TolterodineSubstrate Umm
9531513,
TopiramateInhibitor 11030437,
12102670,
12102670,
15038401,
TorasemideInhibitor Umm
TrabectedinSubstrate 16379042,
16162970,
16379042,
TranylcypromineInhibitor 15049511,
9931427,
11377023,
15049511,
TrimethadioneSubstrate Umm
TrimipramineSubstrate 14520122
TroglitazoneInhibitor,Substrate 10659951,
TroleandomycinInhibitor 15054565
TrospiumInhibitor 10628907
ValdecoxibInhibitor Umm
Valproic AcidInhibitor,Substrate 9606477
VenlafaxineSubstrate Umm
10192828,
VerapamilSubstrate 8750925,
VoriconazoleInhibitor,Substrate 18034666
WarfarinSubstrate,Inhibitor Medicine.iupui.edu/flockhart
10219964
ZafirlukastInhibitor 10870095,
10870095,
ZidovudineSubstrate 7640152,
Source: Www.umm.edu,
8053924,
11996015,
ZolpidemSubstrate 17515707,
10383565,
11996015,
ZonisamideInhibitor,Substrate 15519127,
ZotepineSubstrate 10219963,