Enzyme - Results


CYP: 2C8



Information Structure
Name 2C8
Synonyms
S-mephenytoin 4-hydroxylase
UniProt ID cp2c8_human
Accession Number A8K9N8
B0AZN2
P10632
Q5VX93
Q8WWB1
Q9UCZ9
PDB ID 1PQ2
2NNH
2NNI
2NNJ
2VN0
EC Number1.14.14.1
Drug Interactions
NameRelationReferences
Acetylsalicylic AcidSubstrate Umm
AminophenazoneSubstrate 10199594,
AmiodaroneSubstrate 12530467,
11038157,
15716363,
12530467,
AmitriptylineInhibitor,Substrate 11136296,
AmlodipineInhibitor Umm
AmodiaquineSubstrate 17361129,
15100167,
15771232,
11805197,
15626586,
AmprenavirSubstrate Umm
AtorvastatinInhibitor 15998357,
BezafibrateInhibitor 16176562
BortezomibInhibitor Umm
BrompheniramineSubstrate Umm
BuprenorphineSubstrate 16010532,
15743975,
BupropionSubstrate Umm
CaffeineSubstrate Umm
CapsaicinSubstrate 12641434,
12641434,
CarbamazepineSubstrate,Inducer 10096433,
10907977,
10096433,
CarbinoxamineSubstrate Umm
CefaloridineSubstrate 15194707
CerivastatinSubstrate,Inhibitor 16714062,
10976657,
15716363,
15601807,
15365880,
10976657,
ChininInhibitor 11136296,
ChloramphenicolInhibitor Umm
ChloroquineSubstrate 12967198,
12920490,
12967198,
12756207,
16359408,
CiclosporinInhibitor Umm
CimetidineInhibitor Umm
CisaprideSubstrate 10859153,
10859153,
ClopidogrelInhibitor Umm
ClotrimazoleInhibitor 11136296,
11136296,
15601807,
ClozapineSubstrate Umm
9840430,
CocaineInhibitor 16188404
ColchicineInducer,Inhibitor Umm
ColecalciferolInhibitor 10219964,
CyamemazineSubstrate 17951033
CyclophosphamideInducer,Substrate Umm
9157990,
DapsoneSubstrate 10901692,
10901692,
DelavirdineInhibitor Umm
DexamethasoneInducer 11181490,
15933212,
DexmedetomidineInhibitor Umm
DextromethorphanSubstrate Umm
DextropropoxypheneInhibitor Umm
DiazepamSubstrate 10771285,
DiclofenacSubstrate,Inhibitor Umm
10572000,
15581350,
DiltiazemSubstrate,Inhibitor Umm
9223567,
DisulfiramInhibitor Umm
DolasetronSubstrate Umm
DomperidoneSubstrate 15327587,
15327587,
DorzolamideSubstrate Umm
EfavirenzInhibitor Umm
EntacaponeInhibitor Umm
EprosartanInhibitor Umm
EstradiolSubstrate 11741520,
EtoposideInhibitor Umm
9842986,
FelodipineInhibitor Umm
15601807,
FenofibrateInhibitor 15601807,
FluconazoleInhibitor Umm
FluorouracilSubstrate 11095583
FluoxetineInhibitor,Substrate Umm
FluphenazineInhibitor Umm
FlurbiprofenInhibitor,Substrate Umm
FluvastatinInhibitor,Substrate 15998357,
Umm
15998357,
FluvoxamineInhibitor Umm
FormoterolSubstrate Umm
FosamprenavirSubstrate Umm
FosphenytoinInhibitor,Substrate Umm
GemfibrozilInducer,Inhibitor 15771232,
GlimepirideSubstrate Umm
GlipizideSubstrate Umm
GriseofulvinInducer Umm
HalofantrineSubstrate Umm
10385214,
HalothaneSubstrate Umm
HydrocortisoneInducer 12031713,
IbuprofenInhibitor,Substrate Umm
IfosfamideInducer,Substrate Umm
9157990,
ImatinibInhibitor,Substrate Umm
IndinavirInhibitor Umm
IndometacinInhibitor,Substrate Umm
IpriflavoneInhibitor 17624023
IrbesartanInhibitor,Substrate Umm
15601807,
IsoniazidInhibitor 15304522
KetamineSubstrate Umm
KetobemidoneSubstrate 16278191
KetoconazoleInhibitor 15373932,
14709627,
11038157,
11136296,
15601807,
KetoprofenInhibitor Umm
LansoprazoleInhibitor,Substrate Umm
LeflunomideInhibitor,Substrate Umm
LidocainSubstrate Umm
8866826,
11996015,
LoperamideSubstrate 15365656,
15365656,
LoratadineInhibitor 15601807,
LosartanInhibitor,Substrate Umm
Umm
LovastatinInhibitor 15998357,
15601807,
15998357,
MedroxyprogesteroneInhibitor 15601807,
Mefenamic AcidInhibitor,Substrate Umm
MeloxicamInhibitor,Substrate Umm
MephenytoinSubstrate 8110777,
MethadoneSubstrate 8839037,
MetronidazoleInhibitor Umm
MirtazapineSubstrate 10997935,
11996015,
MometasoneInhibitor 15601807
MontelukastInhibitor 16981900,
15601807,
15608135,
15601807,
15608135,
16670899,
MorphineSubstrate 15743975,
12936704,
NaloxoneSubstrate 16010532
NaproxenSubstrate Umm
9248768,
NicardipineSubstrate,Inhibitor 11996015,
NicotineSubstrate 10350185,
NifedipineInhibitor 15601807,
NilutamideInhibitor 1785203
NilvadipineInhibitor 14993813,
OmeprazoleSubstrate 8894508,
OxybutyninInhibitor 15601807,
PaclitaxelSubstrate 12019187,
16388406,
10659951,
11668219,
9820175,
10460808,
10510156,
9660842,
10064574,
14570767,
15601807,
12920504,
11901098,
157
ParacetamolSubstrate Umm
ParaoxonSubstrate 12669189,
16757081
ParoxetineInhibitor 12756206
Pentamidine IsethionateSubstrate 12920490
PerphenazineSubstrate Umm
PhenazoneSubstrate 8681486,
PhenelzineInhibitor 15304522,
PhenobarbitalInducer,Substrate 11181490,
12815172,
12642468,
PhenprocoumonSubstrate 15054565,
PhenytoinSubstrate,Inducer Umm
8851634,
8819299,
8095200,
2009596,
9393958,
11996015,
PioglitazoneSubstrate,Inhibitor 16867170,
16670899,
PiroxicamInhibitor,Substrate Umm
PravastatinInhibitor Umm
PrimidoneInducer Umm
ProbenecidInducer 15915352
ProgesteroneSubstrate Umm
PropafenoneInhibitor Umm
PropofolSubstrate Umm
9771309,
PyrimethamineInhibitor Umm
QuinidineSubstrate Umm
RaloxifeneInhibitor 15601807,
RepaglinideSubstrate 16372821,
14534525,
15601807,
16176562,
15025742,
12919179,
17253883,
Retinol (vit A)Inhibitor,Substrate 10219964,
RifampicinInducer,Inhibitor,Substrate 15676042,
11368292,
15001966,
9402947,
15371985,
15676042,
12642468,
RifapentineInducer 9402947,
Source: Www.umm.edu
RitonavirInducer,Inhibitor Umm
RofecoxibSubstrate Umm
RosiglitazoneInhibitor,Substrate 10510156,
RutosideInhibitor 11911845
SalmeterolInhibitor 15601807,
SaquinavirInhibitor Umm
SecobarbitalInducer Source: Www.umm.edu
SelegilineSubstrate Umm
12920164,
SeratrodastSubstrate 9010637,
SimvastatinSubstrate,Inhibitor 17178259
Simvastatin And EzetimibeInhibitor Umm
SpironolactoneInhibitor 15601807,
SulfadiazineSubstrate 7628308,
10208642,
15862605,
11996015,
SulfafurazoleSubstrate,Inhibitor Umm
SulfamethoxazoleInhibitor 12019187
SulfaphenazoleInhibitor 7640150,
SulfinpyrazonSubstrate Umm
11996015,
TamoxifenInhibitor 15601807,
TazaroteneSubstrate Cytochrome P450 2C8 And Flavin-containing Monooxygenases Are Involved In The Metab
TegafurSubstrate 11095583,
TegaserodInhibitor 11560869,
TemazepamSubstrate Umm
8948091,
TerbinafineSubstrate 10460803,
10460803,
TerfenadineInhibitor 11136296,
11996015,
TestosteroneSubstrate 11996015,
TetrabenazineInducer 15232626
ThalidomideSubstrate 12060642
TheophyllineSubstrate Umm
ThioridazineInhibitor Umm
TiclopidineInhibitor Umm
TioconazoleInhibitor Umm
TolbutamideSubstrate,Inhibitor 10725317,
10484078,
9522439,
7923194,
8110777,
1857342,
TorasemideSubstrate Medicine.iupui.edu/flockhart
15196026,
11136296,
TretinoinInhibitor,Substrate Umm
TriazolamInhibitor Umm
11136296,
TrimethadioneSubstrate 9879636,
TrimethoprimInhibitor,Substrate 12019187,
12756206,
16867170,
15570183,
15203044,
12019187,
15371985,
15606443,
15570183,
15025742,
TroglitazoneSubstrate,Inhibitor 16372821,
10534310,
TroleandomycinInhibitor 15054565,
15054565,
Valproic AcidInhibitor 9606477
VerapamilSubstrate 12972955,
10336579,
8750925,
WarfarinInhibitor,Substrate Source: Www.umm.edu,
9248768,
ZafirlukastInhibitor,Substrate 16867170,
16670899,
15601807,
16670899,
ZidovudineSubstrate Source: Www.umm.edu,
8053924,
11996015,
ZopicloneSubstrate 10460808,
10460808,
10460808,