Compound - Results

Efavirenz

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Information Structure
Name Efavirenz
Synonyms
(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
DMP 266
Efavirenz
L 743726
Stocrin
Sustiva
ATC J05AG03
CID 3203
CAS 154598524
Drugbank ID DB00625
SMILES FC(F)(F)[C@]1(OC(=O)NC2=CC=C(Cl)C=C12)C#C[C@H]3CC3
Formula C14H9ClF3NO2
Molweight 315.675
Atoms 21
LogP 4.2111
Rotatable Bonds 1
H-Bond Donors 0
H-Bond Acceptors 6
CYP interactions
NameRelationsReferences
1A2Inhibitor 11225565
2B6Substrate Inhibitor Inducer 15864119
16625385
umm
12676886
15194512
15864119
15769884
11159797
14628297
2C8Inhibitor umm
2C9Inhibitor umm
11225565
15983905
2C19Inhibitor 15983905
umm
11225565
2D6Inhibitor 11225565
3A4Substrate Inhibitor Inducer umm
11298066
10622035
15496645
12151999
11996015
11225565
12405866
16625385
Transporter
AC-No.NameReferences
P78381UDP-galactose translocator 21319958
Extrarenal fraction 0.9
Elimination half-life 48h