Compound - Results

Imatinib

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Information Structure
Name Imatinib
Synonyms
112gi019
152459-95-5
1iep
1xbb
220127-57-1
4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide
4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide Methanesulfonate
4-[(4-methylpiperazin-1-yl)methyl]-n-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
4-[(4-methylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
ac-524
ac1l1k0z
akos000280662
alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide
benzamide, 4-((4-methyl)-1-piperazinyl)methyl)-n-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-
benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- (9ci)
bidd:gt0047
brd-k92723993-066-02-9
ccris 9076
Cgp 57148
CGP 57148B
chebi:45783
chembl941
cid5291
d08066
db00619
db03261
en002706
ft-0083542
glamox
glamox (tn)
gleevec
Glivec
hms2089d03
i01-1232
imatinib
imatinib (inn)
imatinib Free Base
imatinib Mesilate
imatinib Mesylate
imatinib Methansulfonate
imatinib [inn:ban]
imatinib, Sti571, Gleevec, Glivec
kinome_3724
ls-182208
ls-187106
n-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
ncgc00159456-02
ncgc00159456-03
ncgc00159456-04
nchembio.117-comp23
nchembio.162-comp5
nchembio.282-comp6
nchembio.83-comp14
nsc743414
s2475_selleck
sti
STI 571
sti-571
sti571
stk617705
unii-bkj8m8g5hi
ATC L01XX28
L01XE01
CID 5291
CAS 152459955
Drugbank ID DB00619
TTD Drug ID DNC001383
SMILES CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC(NC4=NC=CC(=N4)C5=CC=CN=C5)=C(C)C=C3
Formula C29H31N7O
Molweight 493.603
Atoms 37
LogP 4.6121
Rotatable Bonds 8
H-Bond Donors 0
H-Bond Acceptors 8
CYP interactions
NameRelationsReferences
1A2Substrate umm
2C8Substrate Inhibitor umm
2C9Substrate Inhibitor umm
2C19Substrate umm
2D6Substrate Inhibitor umm
3A4Substrate Inhibitor umm
12006504
16122278
14612892
16122278
17180388
16286749
16122278
medicine.iupui.edu/flockhart
9616191
3A5Substrate Inhibitor 16122278
16122278
medicine.iupui.edu/flockhart
9616191
3A7Substrate medicine.iupui.edu/flockhart
Transporter
AC-No.NameReferences
O15245Solute carrier family 22 member 118669873
P08183CD24315805252
P46721Solute carrier organic anion transporter family member 1A221508937
Q8WUG5Neutrophil gelatinase-associated lipocalin receptor 16377569
Q99758ATP-binding cassette transporter 319880777
Q9UNQ0Breast cancer resistance protein18094612
Extrarenal fraction 0.95
Elimination half-life 18h