Compound - Results

Sildenafil

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Information Structure
Name Sildenafil
Synonyms
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
Sildenafil
ATC G04BE03
CID 5212
CAS 139755832
Drugbank ID DB00203
TTD Drug ID DCL000953
SMILES CCCC1=NN(C)C2=C1N=C(NC2=O)C3=C(OCC)C=CC(=C3)S(=O)(=O)N4CCN(C)CC4
Formula C22H30N6O4S
Molweight 474.576
Atoms 33
LogP 2.5675
Rotatable Bonds 7
H-Bond Donors 0
H-Bond Acceptors 9
CYP interactions
NameRelationsReferences
1A1Inhibitor umm
2C9Substrate 9916601
10725306
2C19Substrate Inhibitor umm
10725306
2D6Substrate Inhibitor umm
10725306
2E1Inhibitor umm
3A4Substrate Inhibitor 9916601
12497749
12058245
10546851
11298070
3A5Substrate medicine.iupui.edu/flockhart
3A7Substrate medicine.iupui.edu/flockhart
Transporter
AC-No.NameReferences
P19634Na(+)/H(+) antiporter, amiloride-sensitive 17339532
Extrarenal fraction 0.85
Elimination half-life 4h