Compound - Results

Nifedipine

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Information Structure
Name Nifedipine
Synonyms
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Dimethyl Ester
4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester
4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
5-22-04-00268 (Beilstein Handbook Reference)
Adalat
Adalat CC
BAY A 1040
BRN 0497773
CCRIS 6074
Citilat
Cordipin
Corinfar
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
EINECS 244-598-3
Fenihidin
Fenihidine
Nifedipine
Nifedipino
Nifedipinum
Oxcord
Procardia
Procardia XL
ATC C08CA05
CID 4485
CAS 021829254
Drugbank ID DB01115
TTD Drug ID DAP000529
SMILES COC(=O)C1=C(C)NC(C)=C([C@H]1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OC
Formula C17H18N2O6
Molweight 346.335
Atoms 25
LogP 3.0276
Rotatable Bonds 6
H-Bond Donors 0
H-Bond Acceptors 7
CYP interactions
NameRelationsReferences
1A1Inhibitor 8474022
1A2Inhibitor 10805063
8474022
2B6Inducer 11560876
2C8Inhibitor 15601807
2C9Inhibitor Inducer 10640508
11560876
2D6Substrate Inhibitor 3577206
7620940
8751138
10640508
2E1Inhibitor 10805063
3A4Substrate Inhibitor Inducer 10208645
15635191
8866917
8689938
9384469
9831966
8068867
12538830
11560876
12814972
10923861
11963641
3A5Substrate medicine.iupui.edu/flockhart
12814972
3A7Substrate medicine.iupui.edu/flockhart
Transporter
AC-No.NameReferences
A2RUN4Solute carrier family 6 (Neurotransmitter transporter, dopamine), member 3 isoform CRA_b 19046383
P19634APNH11922896
P49281Natural resistance-associated macrophage protein 2 17293870
Q05940Monoamine transporter 1279122
Extrarenal fraction 1
Elimination half-life 3h