Compound - Results

Diclofenac

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Information Structure
Name Diclofenac
Synonyms
2-((2,6-Dichlorophenyl)amino)benzeneacetic Acid
BRN 2146636
Dichlofenac
Diclofenac
Diclofenac Acid
Diclofenaco
Diclofenacum
Diclophenac
EINECS 239-348-5
Pennsaid
ProSorb-D
ATC M01AB05
M02AA15
S01BC03
D11AX18
CID 3033
CAS 015307865
Drugbank ID DB00586
TTD Drug ID DAP000620
SMILES OC(=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
Formula C14H11Cl2NO2
Molweight 296.149
Atoms 19
LogP 4.4371
Rotatable Bonds 4
H-Bond Donors 0
H-Bond Acceptors 3
CYP interactions
NameRelationsReferences
1A1Substrate 10572000
1A2Substrate Inhibitor umm
10572000
2B6Substrate 10449188
umm
2C8Substrate Inhibitor umm
10572000
15581350
2C9Substrate Inhibitor 15135088
16740353
umm
12065442
11353760
10497136
9335524
14570767
15802386
16308280
2C18Substrate 10449188
10572000
2C19Substrate umm
10449188
10572000
2D6Substrate umm
2E1Inhibitor umm
15135088
9574817
3A4Substrate Inhibitor umm
10027801
10027798
10950847
10572000
46ASubstrate 14640697
Phase2 interactions
NameReferences
UGT 7981423,
9834275
Transporter
AC-No.NameReferences
O15439MOAT-B16454695
P08183CD24319793025
P78381UGT 15334623
Q92887Canalicular multidrug resistance protein17241877
Q9NPD5Solute carrier organic anion transporter family member 1B321389119
Q9UNQ0ATP-binding cassette sub-family G member 218845662
Extrarenal fraction 1.0
Elimination half-life 1.5h