Compound - Results

Tamoxifen

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Information Structure
Name Tamoxifen
Synonyms
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
CCRIS 3275
Citofen
Crisafeno
Diemon
EINECS 234-118-0
HSDB 6782
ICI 47699
Istubol
Nolvadex
NSC 180973
Oncomox
Retaxim
Tamizam
Tamoxen
Tamoxifen
Tamoxifen (Z)
Tamoxifene
Tamoxifeno
Tamoxifenum
trans-Tamoxifen
Valodex
ATC L02BA01
CID 2733525
CAS 010540291
Drugbank ID DB00675
SMILES CCC(C1=CC=CC=C1)=C(/C2=CC=CC=C2)C3=CC=C(OCCN(C)C)C=C3
Formula C32H37NO8
Molweight 563.638
Atoms 41
LogP 4.7476
Rotatable Bonds 13
H-Bond Donors 0
H-Bond Acceptors 9
CYP interactions
NameRelationsReferences
1A1Substrate 12124303
1B1Inhibitor 11160641
2A6Substrate umm
8293548
2B6Substrate Inhibitor 16550168
12124303
12061800
12018981
9270005
8293548
14678248
12023523
2C8Inhibitor 15601807
2C9Substrate Inhibitor medicine.iupui.edu/flockhart
9037249
15286089
12023523
17024799
2C19Substrate 16550168
2D6Substrate Inhibitor 14642736
15632378
16550168
10752644
9037249
15159443
14678248
9270005
12623757
15286089
12419838
12124303
12023523
2E1Substrate 8293548
umm
3A4Substrate Inhibitor Inducer 12419838
15544435
12419016
15762770
11950795
12419838
3A5Substrate medicine.iupui.edu/flockhart
15596297
15159443
3A7Substrate medicine.iupui.edu/flockhart
19AInhibitor 10704911
Phase2 interactions
NameReferences
MET 15288375
NAT 9022126,
18280460,
17564319,
12889515
SUL 19812351,
15987423,
9855017,
12695353,
16150108
UGT 19244109
Transporter
AC-No.NameReferences
P08183P-glycoprotein 117526937
P78381UDP-galactose translocator8706011
Q00325Solute carrier family 25 member 310773018
Extrarenal fraction high
Elimination half-life 143.0h