Compound - Results

Clozapine

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Information Structure
Name Clozapine
Synonyms
5-25-11-00364 (Beilstein Handbook Reference)
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
BRN 0764984
Clorazil
Clozapin
Clozapina
Clozapine
Clozapinum
Clozaril
EINECS 227-313-7
HF-1854
HSDB 6478
Iprox
Leponex
W-801
ATC N05AH02
CID 16104
CAS 005786210
Drugbank ID DB00363
SMILES CN1CCN(CC1)C2=NC3=C(NC4=C2C=CC=C4)C=CC(Cl)=C3
Formula C18H19ClN4
Molweight 326.823
Atoms 23
LogP 3.1721
Rotatable Bonds 1
H-Bond Donors 0
H-Bond Acceptors 3
CYP interactions
NameRelationsReferences
1A1Inducer 10422890
1A2Substrate Inhibitor 12670127
7640149
17214606
9840430
11504269
11151749
10625111
14659489
12969762
12670127
12188102
11996015
10976659
1B1Inducer 10422890
2A6Substrate umm
2C8Substrate umm
9840430
2C9Substrate Inhibitor 10422890
umm
9840430
8866916
10422890
2C19Substrate Inhibitor 10422890
9840430
10422890
8866916
2D6Substrate Inhibitor 7640149
umm
1545398
9840430
11504269
10460810
8866916
2E1Inhibitor umm
3A4Substrate Inhibitor Inducer 10422890
umm
9840430
8866916
Phase2 interactions
NameReferences
NAT 2445415
Transporter
AC-No.NameReferences
Q9P2U7SLC17A7 18155072
Extrarenal fraction 1
Elimination half-life 16h