Compound - Results

Vincristine

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Information Structure
Name Vincristine
Synonyms
22-Oxovincaleukoblastine
CCRIS 5763
EINECS 200-318-1
HSDB 3199
LCR
Leurocristine
NCI-C04864
NSC-67574
VCR
Vincaleukoblastine, 22-oxo-
Vincristina
Vincristine
Vincristinum
Vincrystine
Vinkristin
ATC L01CA02
CID 5978
CAS 000057227
Drugbank ID DB00541
TTD Drug ID DAP000114
Herbal origin all - grass of Madagascar Periwinlke
SMILES CC[C@]1(O)C[C@H]2CN(CCC3=C(NC4=C3C=CC=C4)[C@@](C2)(C(=O)OC)C5=CC6=C(C=C5OC)N(C=O)[C@H]7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@H]89)C(=O)OC)C1
Formula C46H56N4O10
Molweight 824.958
Atoms 64
LogP 4.0942
Rotatable Bonds 11
H-Bond Donors 0
H-Bond Acceptors 13
CYP interactions
NameRelationsReferences
3A4Substrate Inhibitor 8221648
8452560
9732391
10613614
10613614
3A5Substrate 16679390
3A7Substrate medicine.iupui.edu/flockhart
Transporter
AC-No.NameReferences
P08183Multidrug resistance protein 120699370
P33527ATP-binding cassette sub-family C member 114622113
Extrarenal fraction 0.8
Elimination half-life 85.0h