Compound - Results

Amitriptyline

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Information Structure
Name Amitriptyline
Synonyms
10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(sup 5),gamma-propylamine
3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin
3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
5-(3-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-
Adepress
Adepril
Amitriptilina
Amitriptylin
Amitriptyline
Amitriptylinum
Amytriptylin
BRN 2217885
Damilen
Damitriptyline
EINECS 200-041-6
Elavil
Flavyl
HSDB 3007
Lantron
MK 230
N 750
Proheptadiene
Redomex
Ro 4-1575
Seroten
Triptanol
Triptilin
Triptisol
Tryptanol
ATC N06AA09
CID 2160
CAS 000050486
Drugbank ID DB00321
TTD Drug ID DAP000864
SMILES CN(C)CCC=C1/C2=C(CCC3=C1C=CC=C3)C=CC=C2
Formula C20H23N
Molweight 277.403
Atoms 21
LogP 4.1686
Rotatable Bonds 3
H-Bond Donors 0
H-Bond Acceptors 1
CYP interactions
NameRelationsReferences
1A2Substrate Inhibitor 11990081
umm
15199661
9549641
2B6Substrate 11259560
2C8Substrate Inhibitor umm
11136296
2C9Substrate umm
9131945
2C19Substrate Inhibitor 9549641
9399333
9867310
9923577
12172336
umm
2D6Substrate Inhibitor 12172336
16175144
9143866
medicine.iupui.edu/flockhart
9131945
11259560
11888334
9143866
2E1Substrate Inhibitor umm
9549641
9574817
11996015
3A4Substrate Inhibitor umm
9131945
9549641
16415122
17598095
3A5Substrate 11136296
14637191
Phase2 interactions
NameReferences
UGT 20133892,
17495417,
21497036
Transporter
AC-No.NameReferences
P23975Sodium-dependent noradrenaline transporter21129446
P78381UDP-galactose translocator11355849
Extrarenal fraction 0.9
Elimination half-life 15.0h