Compound - Results

Miconazole

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Information Structure
Name Miconazole
Synonyms
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
5-23-04-00320 (Beilstein Handbook Reference)
BRN 0965511
CCRIS 7924
Daktarin IV
EINECS 245-324-5
Miconazol
Miconazole
Miconazolo
Miconazolum
MJR 1762
Monistat IV
NSC 170986
R 18134
ATC A01AB09
A07AC01
D01AC02
G01AF04
J02AB01
S02AA13
CID 4189
CAS 022916478
Drugbank ID DB01110
TTD Drug ID DAP000154
SMILES ClC1=CC=C(CO[C@H](CN2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C(Cl)=C1
Formula C18H14Cl4N2O
Molweight 416.129
Atoms 25
LogP 6.4548
Rotatable Bonds 6
H-Bond Donors 0
H-Bond Acceptors 2
CYP interactions
NameRelationsReferences
1A2Inhibitor 16141569
16141569
2A6Inhibitor 9143352
2B6Inhibitor 11854151
2C9Inhibitor 10945865
10709776
16141567
16141567
2C19Inhibitor 16141567
11854151
16141567
2D6Inhibitor 16141569
11854151
16141569
2E1Inhibitor 16141569
16141569
3A4Substrate Inhibitor 11996015
15135088
11B1Inhibitor 7663533
19AInhibitor 15554355
Extrarenal fraction 1
Elimination half-life 24h
Ketoconazole

Java required.


Information Structure
Name Ketoconazole
Synonyms
(+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
BRN 4303081
DRG-0073
EINECS 265-667-4
Fungarest
Fungoral
Ketoconazol
Ketoconazole
Ketoconazolum
Ketoderm
Ketoisdin
KW-1414
Nizoral
Orifungal M
Panfungol
R 41400
ATC D01AC08
G01AF11
J02AB02
CID 3823
CAS 065277421
SMILES CC(=O)N1CCN(CC1)C2=CC=C(OC[C@@H]3CO[C@](CN4C=CN=C4)(O3)C5=C(Cl)C=C(Cl)C=C5)C=C2
Formula C26H28Cl2N4O4
Molweight 531.431
Atoms 36
LogP 4.2087
Rotatable Bonds 8
H-Bond Donors 0
H-Bond Acceptors 5
CYP interactions
NameRelationsReferences
1A1Inhibitor Inducer 14709627
10821163
17283379
1A2Inhibitor umm
9351907
1B1Inhibitor 14709627
2A6Inhibitor umm
9143352
11978200
2B6Inhibitor 14709627
2C8Inhibitor 15373932
14709627
11038157
11136296
15601807
2C9Inhibitor 14709627
9764927
11854151
15618748
15373932
2C19Inhibitor 14709627
10192828
10383565
15618748
2D6Inhibitor umm
15618748
2E1Inhibitor 15027815
2F1Inhibitor 14709627
3A4Substrate Inhibitor Inducer 9616194
15618748
8690825
1371482
umm
15821046
12817528
14712470
12624000
12072427
10048600
9616194
15180387
18082278
3A5Substrate Inhibitor Inducer 12814972
15180387
18082278
9812178
17361128
8690825
1371482
3A7Inhibitor 8690825
1371482
4F2Inhibitor 16997912
11B1Inhibitor 7663533
51AInhibitor 15611056
Transporter
AC-No.NameReferences
P08183CD24318197554
P78381UDP-galactose transporter 16679387
Q92887Canalicular multispecific organic anion transporter 119070657
Q9UNQ0ATP-binding cassette sub-family G member 217518356
Q9Y6L6Solute carrier organic anion transporter family member 1B121456052