Compound - Results

Methylprednisolone

Java required.


Information Structure
Name Methylprednisolone
Synonyms
1-Dehydro-6alpha-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
4-08-00-03498 (Beilstein Handbook Reference)
6-alpha-Methylprednisolone
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
A-Methapred
Artisone-wyeth
Besonia
BRN 2340300
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
Depo-Medrol (acetate)
Dopomedrol
DRG-0050
EINECS 201-476-4
Esametone
Firmacort
HSDB 3127
Lemod
Medesone
Medixon
Medlone 21
Medrate
Medrol
Medrol Adt Pak
Medrol Dosepak
Medrone
MEPRDL
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolone
Methylprednisolonum
Metilbetasone
Metilprednisolona
Metilprednisolone
Metrisone
Metrocort
Metysolon
Moderin
Nirypan
Noretona
NSC-19987
Predni N Tablinen
Prednisolone, 6alpha-methyl-
Prednisolone, Methyl-
Prednol- L
Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6alpha,11beta)-
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-
Promacortine
Reactenol
Sieropresol
Solomet
Solu-medrol
Solu-Medrol (sodium Succinate)
Summicort;
Suprametil
U 7532
U-67,590A
Urbason
Urbasone
Wyacort
ATC D07AA01
D10AA02
H02AB04
CID 4159
CAS 000083432
Drugbank ID DB00959
SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)C=CC(=O)C=C14
Formula C22H30O5
Molweight 374.471
Atoms 27
LogP 1.8036
Rotatable Bonds 2
H-Bond Donors 0
H-Bond Acceptors 5
CYP interactions
NameRelationsReferences
3A4Substrate Inhibitor 9797792
11422002
8849485
11996015
9797792
Transporter
AC-No.NameReferences
P19634SLC9A18380155
Q86YT5Solute carrier family 13 member 517290012
Extrarenal fraction 0.9
Elimination half-life 3 h
Hydrocortisone

Java required.


Information Structure
Name Hydrocortisone
Synonyms
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydroxycortisone
17-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
4-Pregnene-11beta,17alpha,21-triol-3,20-dione
Acticort
Aeroseb-HC
AI3-25006
Ala-Scalp
Alacort
Algicirtis
Amberin
Anflam
Anti-inflammatory Hormone
Aquacort
Aquanil HC
Barseb HC
Basan-Corti
CCRIS 5854
Cetacort
Clear Aid
Cleiton
Cobadex
Compound F (kendall)
Cort-Dome
Cortanal
Cortef
Cortenema
Cortesal
Corticreme
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol Alcohol
Cortisolonum
Cortisporin Otico
Cortispray
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Delacort
Derm-Aid
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Efcorbin
Efcortelan
EINECS 200-020-1
Eldecort
Eldercort
Epicort
Epiderm H
Esiderm H
Evacort
Ficortril
Foille Insetti
Genacort
Genacort (lotion)
Gyno-Cortisone
HC
Heb Cort
Heb-Cort
Hidalone
Hidro-colisona
Hidrocortisona
HSDB 3339
Hycort
Hycortol
Hycortole
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydrocorticosterone
Hydrocortisone
Hydrocortisone Alcohol
Hydrocortisone Free Alcohol
Hydrocortisonum
Hydrocortisyl
Hydrocortone
Hydroxycortisone
Hytisone
Hytone
Hytone Lotion
Idrocortisone
Incortin-H
Incortin-hydrogen
Kendalls Compound F
Komed HC
Kyypakkaus
Lacticare-HC
Lactisona
Lubricort
Maintasone
Meusicort
Mildison
Milliderm
Neosporin-H Ear
NSC 10483
Nutracort
Optef
Otosone-F
Penecort
Permicort
Polcort H
Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)-
Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-
Preparation H Hydrocortisone Cream
Prevex HC
Proctofoam
Rectoid
Reichsteins Substance M
Remederm HC
Sanatison
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stiefcorcil
Systral Hydrocort
Tarcortin
Texacort
Texacort Lotion 25
Timocort
Transderma H
Traumaide
Uniderm
ATC A01AC03
A07EA02
C05AA01
D07AA02
D07XA01
H02AB09
S01BA02
S01CB03
S02BA01
CID 3640
CAS 000050237
Drugbank ID DB00741
SMILES C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Formula C21H30O5
Molweight 362.46
Atoms 26
LogP 1.7816
Rotatable Bonds 2
H-Bond Donors 0
H-Bond Acceptors 5
CYP interactions
NameRelationsReferences
1B1Inhibitor 8674863
2C8Inducer 12031713
3A4Substrate Inhibitor Inducer 1554942
11996015
1302569
15726657
11471773
11318772
11206036
10829051
2590599
11996015
14715379
8068867
3A5Substrate 16141800
3A7Substrate 9644715
9644715
11B1Substrate 15356073
11B2Substrate 11996015
15356073
Phase2 interactions
NameReferences
GST 11788566
MET 571728
NAT 12168848
SUL 11454732,
19523470,
3192164
UGT 3123148,
16817017
Transporter
AC-No.NameReferences
P08183Multidrug resistance protein 121182940
Q8TCC7Organic anion transporter 316835396
Q9NRA2Membrane glycoprotein HP59 6259794
Extrarenal fraction 1
Elimination half-life 1.5h