Compound - Results

Bendroflumethiazide

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Information Structure
Name Bendroflumethiazide
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide
3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide
4-27-00-08041 (Beilstein Handbook Reference)
6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide
Aprinox
Be 724-A
Bendrofluazide
Bendroflumethiazide
Bendroflumethiazidum
Bendroflumetiazida
Bendroflumetiazide
Bentride
Benuron
Benzhydroflumethiazide
Benzylhydroflumethiazide
Benzylrodiuran
Berkozide
BHFT
BL H368
Bristuric
Bristuron
BRN 0373316
Centyl
EINECS 200-800-1
Flumesil
FT 8
FT 81
HSDB 3293
Intolex
Livesan
Naturetin
Neo-naclex
Neo-rontyl
Niagaril
Nikion
Orsile
Pluryl
Pluryle
Plusuril
Poliuron
Relan Beta
Repicin
Salural
Salures
Sinesalin
Sodiuretic
Thiazidico
Urlea
ATC C03AA01
CID 2315
CAS 000073483
Drugbank ID DB00436
TTD Drug ID DAP000188
SMILES NS(=O)(=O)C1=CC2=C(N[C@H](CC3=CC=CC=C3)NS2(=O)=O)C=C1C(F)(F)F
Formula C15H14F3N3O4S2
Molweight 421.415
Atoms 27
LogP 4.9541
Rotatable Bonds 4
H-Bond Donors 0
H-Bond Acceptors 10
Phase2 interactions
NameReferences
MET 8866635,
8866635
Extrarenal fraction 0.7
Elimination half-life 3.5h
Hydroflumethiazide

Java required.


Information Structure
Name Hydroflumethiazide
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide
3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
3,4-Dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine
3,4-Dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine 1,1-dioxide
3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
4-27-00-08035 (Beilstein Handbook Reference)
6-Trifluoromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
6-Trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
7-Sulfamoyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine
7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1, 1-dioxide
7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
Bristab
Bristurin
BRN 0342692
Di-ademil
Di-adenil
Dihydroflumethazide
Dihydroflumethiazide
Diucardin
Diuredemina
Diurometon
EINECS 205-173-8
Elodrin
Elodrine
Enjit
Finuret
Flutizide
Glomerulin
Hidroalogen
Hidroflumetiazid
Hidroflumetiazida
HSDB 3340
Hydol
Hydrenox
Hydroflumethazide
Hydroflumethiazide
Hydroflumethiazidum
Hydroflumethizide
Idroflumetiazide
Leodrine
Metflorylthiazidine
Methforylthiazidine
Naciex (glaxo)
NaClex
NSC 44627
Olmagran
Robezon
Rodiuran
Rontyl
Saluron
Sisuril
Spandiuril
Trifluoromethylhydrazide
Trifluoromethylhydrothiazide
Vergonil
ATC C03AA02
CID 3440
CAS 000135091
Drugbank ID DB00774
TTD Drug ID DAP000043
SMILES NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1C(F)(F)F
Formula C12H11ClN2O5S
Molweight 330.744
Atoms 21
LogP 3.7448
Rotatable Bonds 5
H-Bond Donors 0
H-Bond Acceptors 7
Hydrochlorothiazide

Java required.


Information Structure
Name Hydrochlorothiazide
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide
3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
3,4-Dihydrochlorothiazide
6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
Acesistem
Acuilix
Aldactazide 25/25
Aldazida
Aldectazide 50/50
Aldoril D30
Aldoril D50
Apo-Hydro
Aquarills
Aquarius
Aquazide H
Aquazide-H
Bremil
Briazide
BRN 0625101
Carozide
Catiazida
CCRIS 2082
Chlorizide
Chlorosulthiadil
Chlorsulfonamidodihydrobenzothiadiazine Dioxide
Chlorzide
Chlothia
Cidrex
Clorana
Concor Plus
Condiuren
Diaqua
Dichlorosal
Dichlotiazid
Dichlotride
Diclotride
Didral
Dihydran
Dihydrochlorothiazid
Dihydrochlorothiazide
Dihydrochlorothiazidum
Dihydroxychlorothiazidum
Direma
Disalunil
Disothiazid
Diu 25 Vigt
Diu-melusin
Diurogen
Dixidrasi
Drenol
Dyazide
EINECS 200-403-3
Esidrex
Esidrix
Esoidrina
Fluvin
HCT-Isis
HCTZ
HCZ
Hidril
Hidro-Niagrin
Hidrochlortiazid
Hidroclorotiazida
Hidroronol
Hidrosaluretil
Hidrotiazida
HSDB 3096
Hyclosid
Hydril
Hydro Par
Hydro-Aquil
Hydro-D
Hydro-Diuril
Hydro-Saluric
Hydro-T
Hydrochlorothiazid
Hydrochlorothiazide
Hydrochlorothiazidum
Hydrochlorthiazide
Hydrochlorthiazidum
Hydrocot
Hydrodiuretic
Hydrodiuril
Hydrosaluric
Hydrothide
Hydrozide
Hydrozide Injection, Veterinary
Hypothiazid
Hypothiazide
Hypothiazide (C7H8ClN3O4S2)
Hytrid
Idroclorotiazide
Idrotiazide
Inderide 80/25
Indroclor
Ivaugan
Jen-Diril
Manuril
Maschitt
Mazide 25 Mg
Medozide
Megadiuril
Microzide
Mictrin
Mikorten
Modurcen
Moduretic
Natrinax
NCI-C55925
Nefrix
Nefrol
Neo-codema
Neo-Flumen
Neo-Minzil
Neoflumen
Newtolide
Novodiurex
NSC 53477
Oretic
Pantemon
Panurin
Raunova Plus
Ro-Hydrazide
Roxane
Saldiuril
Selozide
Servithiazid
Spironazide
SU 5879
Tandiur
Thiuretic
Unazid
Urodiazin
Urozide
Vasoretic
Vetidrex
Ziac
Zide
ATC C03AA03
CID 3639
CAS 000058935
TTD Drug ID DAP000750
SMILES NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1Cl
Formula C7H8ClN3O4S2
Molweight 297.739
Atoms 17
LogP 2.9774
Rotatable Bonds 1
H-Bond Donors 0
H-Bond Acceptors 7
Transporter
AC-No.NameReferences
Q13621Solute carrier family 12 member 115564765
Extrarenal fraction 0.05
Elimination half-life 7.0h
Chlorothiazide

Java required.


Information Structure
Name Chlorothiazide
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Alurene
CCRIS 5999
Chlorosal
Chlorothiazid
Chlorothiazide
Chlorothiazidum
Chlorthiazid
Chlorthiazide
Chlorthiazidum
Chlortiazid
Chlorurit
Chlotride
Clorotiazida
Clorotiazide
Clotride
Diuresal
Diuril
Diuril Boluses, Veterinary
Diurilix
Diurite
Diutrid
EINECS 200-404-9
Flumen
HSDB 3030
Minzil
Neo-dema
NSC 25693
Salisan
Salunil
Saluretil
Saluric
SK-Chlorothiazide
Thiazide
Urinex
Warduzide
Yadalan
ATC C03AA04
CID 2720
CAS 000058946
Drugbank ID DB00880
TTD Drug ID DAP000605
SMILES NS(=O)(=O)C1=CC2=C(C=C1Cl)N=CNS2(=O)=O
Formula C7H6ClN3O4S2
Molweight 295.723
Atoms 17
LogP 2.5654
Rotatable Bonds 1
H-Bond Donors 0
H-Bond Acceptors 7
CYP interactions
NameRelationsReferences
1A1Inducer 11684361
1A2Inducer 11684361
Transporter
AC-No.NameReferences
O15439Multidrug resistance-associated protein 418724382
Q8TCC7Solute carrier family 22 member 818216144
Polythiazide

Java required.


Information Structure
Name Polythiazide
Synonyms
2-Methyl-3-(beta,beta,beta-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide
6-Chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide
BRN 0770371
CCRIS 6094
Drenusil
EINECS 206-468-4
HSDB 850
Nephril
NSC 108161
P 2525
P-2525
Politiazida
Polythiazide
Polythiazidum
Renese
ATC C03AA05
CID 4870
CAS 000346189
Drugbank ID DB01324
TTD Drug ID DAP000751
SMILES CN1[C@@H](CSCC(F)(F)F)NC2=C(C=C(C(Cl)=C2)S(N)(=O)=O)S1(=O)=O
Formula C11H13ClF3N3O4S3
Molweight 439.882
Atoms 25
LogP 4.5928
Rotatable Bonds 5
H-Bond Donors 0
H-Bond Acceptors 10
Transporter
AC-No.NameReferences
O15439Multidrug resistance-associated protein 418724382
Q8TCC7Solute carrier family 22 member 818216144
Trichlormethiazide

Java required.


Information Structure
Name Trichlormethiazide
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
3-Dichloromethylhydrochlorothiazide
6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
6-Chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
Achletin
Anistadin
Aponorin
BRN 0629145
Carvacron
Chlopolidine
Ciba 7057-Su
Cretonin
Diu-Hydrin
Diurazida
Diurese
Diuroral
EINECS 205-118-8
Esmarin
Eurinol
Fluitran
Flurese
Flurese (VAN)
Flutra
Gangesol
HSDB 3406
Hydrotrichlorothiazide
Intromene
Isestran
Kubacron
Metahydrin
Nakva
Naqua
NSC 61560
Salurin (wadel)
Schebitran
Tachionin
Tolcasone
Trichlordiuride
Trichlormetazid
Trichlormethiazid
Trichlormethiazide
Trichlormethiazidum
Trichloromethiadiazide
Trichloromethiazide
Triclordiuride
Triclormetiazida
Triclormetiazide
Triflumen
ATC C03AA06
CID 5560
CAS 000133675
Drugbank ID DB01021
TTD Drug ID DAP000035
SMILES NS(=O)(=O)C1=CC2=C(N[C@@H](NS2(=O)=O)C(Cl)Cl)C=C1Cl
Formula C8H8Cl3N3O4S2
Molweight 380.656
Atoms 20
LogP 4.1497
Rotatable Bonds 2
H-Bond Donors 0
H-Bond Acceptors 7
Transporter
AC-No.NameReferences
O15439Multidrug resistance-associated protein 418724382
Q8TCC7Solute carrier family 22 member 818216144
Cyclopenthiazide

Java required.


Information Structure
Name Cyclopenthiazide
Synonyms
3-Cyclopentylmethyl Hydrochlorothiazide Deriv
6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Benesal (VAN)
BRN 0630346
Ciba 8341-Su
Ciclopentiazida
Ciclopentiazide
Cyclomethiazide
Cyclometiazid
Cyclopenthiazide
Cyclopenthiazidum
Cyclopentiazid
EINECS 212-012-5
Navidreks
Navidrex
Navidrex K
Navidrix
NSC 107679
Salimed
Salimid
Salurilo-C
SU 8341
Tsiklometiazid
Ultra-Minzil
ATC C03AA07
CID 2904
CAS 000742201
SMILES ON(O)SC1=CC2=C(N[C@H](C[C@H]3CCCC3)NS2(=O)=O)C=C1Cl
Formula C13H18ClN3O4S2
Molweight 379.883
Atoms 23
LogP 4.9263
Rotatable Bonds 3
H-Bond Donors 0
H-Bond Acceptors 7
Transporter
AC-No.NameReferences
O15439Multidrug resistance-associated protein 418724382
Q8TCC7Solute carrier family 22 member 818216144
Methyclothiazide

Java required.


Information Structure
Name Methyclothiazide
Synonyms
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
Aquatensen
BRN 0765361
CI-625
Ciba 7272-Su
Duretic
EINECS 205-172-2
Enduron
Enduronum
HSDB 3363
Methyclothiazid
Methyclothiazide
Methyclothiazidum
Methycyclothiazide
Meticlotiazida
Meticlotiazide
Naturon
Naturon (VAN)
NSC-110431
ATC C03AA08
CID 4121
CAS 000135079
Drugbank ID DB00232
TTD Drug ID DAP000746
SMILES CN1[C@H](CCl)NC2=C(C=C(C(Cl)=C2)S(N)(=O)=O)S1(=O)=O
Formula C9H11Cl2N3O4S2
Molweight 360.237
Atoms 20
LogP 3.5361
Rotatable Bonds 2
H-Bond Donors 0
H-Bond Acceptors 7
Transporter
AC-No.NameReferences
O15439Multidrug resistance-associated protein 418724382
Q8TCC7Solute carrier family 22 member 818216144
Cyclothiazide

Java required.


Information Structure
Name Cyclothiazide
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo(2.2.1)hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-, 1,1-dioxide
3-Bicyclo(2.2.1)hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
35483
6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
Anhydron
Aquirel
BRN 0722843
Ciclotiazida
Ciclotiazide
Cyclothiazide
Cyclothiazidum
Doburil
EINECS 218-859-7
HSDB 3310
Lilly 35,483
MDi 193
Renazide
Valmiran
ATC C03AA09
CID 2910
CAS 002259963
Drugbank ID DB00606
TTD Drug ID DAP000604
SMILES NS(=O)(=O)C1=CC2=C(N[C@H](NS2(=O)=O)[C@@H]3C[C@H]4C[C@@H]3C=C4)C=C1Cl
Formula C14H16ClN3O4S2
Molweight 389.878
Atoms 24
LogP 4.5582
Rotatable Bonds 2
H-Bond Donors 0
H-Bond Acceptors 7
Transporter
AC-No.NameReferences
O15439Multidrug resistance-associated protein 418724382
Q8TCC7Solute carrier family 22 member 818216144
Mebutizide

Java required.


Information Structure
Name Mebutizide
Synonyms
EINECS 222-660-0
Mebutizida
Mebutizide
Mebutizidum
ATC C03AA13
CID 71652
CAS 003568001
SMILES CC[C@H](C)[C@@H](C)[C@H]1NC2=C(C=C(C(Cl)=C2)S(N)(=O)=O)S(=O)(=O)N1
Formula C13H20ClN3O4S2
Molweight 381.899
Atoms 23
LogP 5.0282
Rotatable Bonds 4
H-Bond Donors 0
H-Bond Acceptors 7
Transporter
AC-No.NameReferences
O15439Multidrug resistance-associated protein 418724382
Q8TCC7Solute carrier family 22 member 818216144