Compound - Results

Prazosin

Java required.


Information Structure
Name Prazosin
Synonyms
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
5-25-13-00365 (Beilstein Handbook Reference)
BRN 0768345
EINECS 242-885-8
Furazosin
HSDB 3298
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-
Prazosin
Prazosina
Prazosine
Prazosinum
Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-
ATC C02CA01
CID 4893
CAS 019216569
Drugbank ID DB00457
TTD Drug ID DAP000300
SMILES COC1=CC2=C(C=C1OC)C(N)=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4
Formula C19H21N5O4
Molweight 383.401
Atoms 28
LogP 2.3687
Rotatable Bonds 5
H-Bond Donors 0
H-Bond Acceptors 7
CYP interactions
NameRelationsReferences
1A1Substrate 15627480
Transporter
AC-No.NameReferences
O15245Solute carrier family 22 member 112110607
Q9UNQ0CD33818089721
Extrarenal fraction 1
Elimination half-life 2.5h
Indoramin

Java required.


Information Structure
Name Indoramin
Synonyms
3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole
5-22-10-00116 (Beilstein Handbook Reference)
BRN 0494035
EINECS 248-041-5
Indoramin
Indoramina
Indoramine
Indoraminum
N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)benzamide
N-(1-(2-Indol-3-ylethyl)-4-piperidyl)benzamide
ATC C02CA02
CID 33625
CAS 026844122
SMILES O=C(N[C@H]1CCN(CC1)CCC2=CNC3=C2C=CC=C3)C4=CC=CC=C4
Formula C22H25N3O
Molweight 347.453
Atoms 26
LogP 3.9336
Rotatable Bonds 6
H-Bond Donors 0
H-Bond Acceptors 4
CYP interactions
NameRelationsReferences
2D6Substrate 9149375
1472073
11996015
Transporter
AC-No.NameReferences
O15245Solute carrier family 22 member 112110607
Q9UNQ0CD33818089721
Trimazosin

Java required.


Information Structure
Name Trimazosin
Synonyms
EINECS 252-732-7
Trimazosin
Trimazosine
Trimazosino
Trimazosinum
ATC C02CA03
CID 37264
CAS 035795165
SMILES COC1=CC2=C(N=C(N=C2N)N3CCN(CC3)C(=O)OCC(C)(C)O)C(OC)=C1OC
Formula C20H29N5O6
Molweight 435.474
Atoms 31
LogP 1.8514
Rotatable Bonds 8
H-Bond Donors 0
H-Bond Acceptors 9
Transporter
AC-No.NameReferences
O15245Solute carrier family 22 member 112110607
Q9UNQ0CD33818089721
Doxazosin

Java required.


Information Structure
Name Doxazosin
Synonyms
1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin
1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin
Doxazosin
Doxazosina
Doxazosine
Doxazosinum
UK 33274
ATC C02CA04
G04CA05
CID 3157
CAS 074191858
Drugbank ID DB00590
TTD Drug ID DAP000381
SMILES COC1=CC2=C(C=C1OC)C(N)=NC(=N2)N3CCN(CC3)C(=O)[C@@H]4COC5=C(O4)C=CC=C5
Formula C23H25N5O5
Molweight 451.475
Atoms 33
LogP 2.3019
Rotatable Bonds 5
H-Bond Donors 0
H-Bond Acceptors 8
CYP interactions
NameRelationsReferences
2C19Substrate https://www.pfizerpro.com/product_info/cardura_xl_pi_clinical_pharmacology.jsp
2D6Substrate https://www.pfizerpro.com/product_info/cardura_xl_pi_clinical_pharmacology.jsp
3A4Substrate https://www.pfizerpro.com/product_info/cardura_xl_pi_clinical_pharmacology.jsp
Transporter
AC-No.NameReferences
A5D8U6ABCA1 protein 17556657
Extrarenal fraction 0.95
Elimination half-life 12h
Urapidil

Java required.


Information Structure
Name Urapidil
Synonyms
5-25-15-00402 (Beilstein Handbook Reference)
6-(3-(4-(o-Methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil
B-66256
BRN 0725782
Ebrantil
EINECS 252-130-4
NSC 310405
Urapidil
Urapidilum
ATC C02CA06
CID 5639
CAS 034661751
TTD Drug ID DCL001018
SMILES COC1=C(C=CC=C1)N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2
Formula C20H29N5O3
Molweight 387.476
Atoms 28
LogP 0.7927
Rotatable Bonds 7
H-Bond Donors 0
H-Bond Acceptors 5
Transporter
AC-No.NameReferences
A5D8U6ABCA1 protein 17556657
Extrarenal fraction 0.7
Elimination half-life 3h
Terazosin

Java required.


Information Structure
Name Terazosin
Synonyms
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine
Blavin
Flumarc
Fosfomic
Terazosin
Terazosina
Terazosine
Terazosinum
Vasomet
ATC C02CA08
G04CA03
CID 969465
CAS 063590647
SMILES COC1=CC2=C(C=C1OC)C(N)=NC(=N2)N3CCN(CC3)C(=O)[C@H]4CCCO4
Formula C19H25N5O4
Molweight 387.433
Atoms 28
LogP 1.6409
Rotatable Bonds 5
H-Bond Donors 0
H-Bond Acceptors 7
Transporter
AC-No.NameReferences
A5D8U6ABCA1 protein 17556657
Extrarenal fraction 0.95
Elimination half-life 10h