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Target Details
Name:
Tryptase beta-2
Uniprot name:
TRYB2_HUMAN
Accession Numbers:
O95827
P20231
Q15664
Q9UQI6
Q9UQI7
EC-Number:
3.4.21.59
Organism:
Homo sapiens
Human
PDB IDs:
1A0L
1AAO
2BM2
2FPZ
2FS8
2FS9
2FWW
2FXR
2GDD
2ZA5
KEGG Pathways:
-
Drugs:
Name
PubChem ID
Source
References
Interaction
(2S,4R)-1-ACETYL-N-[(1S)-4-[(AMINOIMINOMETHYL)AMINO]-1-(2-BENZOTHIAZOLYLCARBONYL)BUTYL]-4-HYDROXY-2-PYRROLIDINECARBOXAMIDE
5287596
BindingDB
-
show
4-PIPERIDINEBUTYRATE
11840929
DrugBank
-
show
44311343
44311343
BindingDB
-
show
AC1L42OR
177340
BindingDB
-
show
AMIDO PHENYL PYRUVIC ACID
2138
DrugBank
-
show
BABIM
2387
BindingDB
-
show
C4A
6857707
BindingDB
-
show
CHEBI:647029
44350298
BindingDB
-
show
CHEBI:652196
44350482
BindingDB
-
show
CHEMBL104064
10116936
BindingDB
-
show
CHEMBL104220
22945986
BindingDB
-
show
CHEMBL104309
44336204
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-
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CHEMBL104354
44336232
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-
show
CHEMBL104434
22945926
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-
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CHEMBL104601
22945942
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-
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CHEMBL106146
22946014
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-
show
CHEMBL106183
44336291
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CHEMBL106903
22945934
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CHEMBL107095
22946022
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CHEMBL107226
44336229
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CHEMBL107233
44336251
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CHEMBL107427
22946015
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CHEMBL107476
44336330
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CHEMBL107493
44339230
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CHEMBL107690
22946001
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CHEMBL107791
22945993
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CHEMBL107805
44336226
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CHEMBL109254
44338973
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CHEMBL109504
44339161
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CHEMBL109602
44339429
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44340074
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44339858
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44339185
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44339223
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44338985
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44339947
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44338987
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44339240
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44340116
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44339426
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44339195
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44339413
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44339412
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44340079
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44340080
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44339434
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44339162
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44340005
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44340289
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44340241
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44340240
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44340255
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44340315
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44340256
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44340086
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44339181
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44342637
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11785507
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44350109
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44350213
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44350351
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44350231
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10647648
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44363121
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10647871
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10528106
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10622602
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10695507
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10527664
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10790297
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10504321
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10835053
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10624038
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10504386
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10504894
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10526456
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44373355
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10390640
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44386061
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44386111
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44385971
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44386595
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44386640
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44390059
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44390058
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11354224
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11262416
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44390106
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44390036
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44390025
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44390107
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44390082
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44394341
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44394011
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44394176
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44394662
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44394199
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44394266
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44396602
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44396542
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44394164
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44394277
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44394235
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44394231
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44396541
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44414412
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44398889
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44398930
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44398837
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44399521
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44398932
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44398671
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44399313
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44399288
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10139526
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44398708
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44399364
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44399415
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44399383
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44399418
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44399336
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44411942
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44411828
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44411620
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44411580
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44411626
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44411621
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44411566
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44411617
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10271568
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10296435
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44414092
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44414341
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44414474
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44414454
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44414360
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15984063
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44414430
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44414431
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44414194
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44414065
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44414335
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44414582
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44414510
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44414559
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44414566
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44414567
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44414333
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44414334
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44414438
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44414482
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44414407
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44414408
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44414332
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44315675
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44315644
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44316026
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44311546
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44414409
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44289264
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44289296
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44289354
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44289263
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CHEMBL297220
10417378
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44289153
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18397352
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44311287
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44311563
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44311468
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44311098
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44311539
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44311578
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44311153
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44311438
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44314690
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44314474
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44314388
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44311392
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44311641
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10044514
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44315912
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44314666
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10391699
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44311559
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44315849
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18397347
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44311230
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44311114
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44315913
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44315915
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44315914
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22010100
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18397360
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44311008
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44315678
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44311304
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44340242
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18397359
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44314462
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44314160
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44315636
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44314667
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18397357
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44316049
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9872983
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44314742
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44314678
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44315852
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18397344
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44315642
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44311463
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44315450
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9810198
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44314464
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44314679
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44315391
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44316015
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22945980
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22945995
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44336184
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44339129
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22945973
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22945990
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44339130
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9804775
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44336333
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10185292
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22945969
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9914247
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9935730
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44414211
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44414268
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10439687
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18397370
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44311245
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44311459
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18397354
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22010118
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22945978
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44339330
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44315845
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44399511
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10111743
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9875345
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44311488
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CHEMBL70155
44311564
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CHEMBL70350
44311229
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CHEMBL70404
44311440
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CHEMBL70410
44311404
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CHEMBL70523
44311465
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CHEMBL70529
44311149
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CHEMBL70533
44311705
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CHEMBL70619
44311219
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CHEMBL70665
44311518
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CHEMBL70666
44311519
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CHEMBL70703
44311579
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CHEMBL70763
44311464
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CHEMBL70766
44311439
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CHEMBL70813
44311467
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CHEMBL70917
44311409
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CHEMBL70964
44311511
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CHEMBL71037
9802488
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CHEMBL71061
44311381
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CHEMBL71072
44311355
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CHEMBL71121
44311637
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CHEMBL71377
44311341
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CHEMBL72238
44311503
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CHEMBL72279
10367277
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CHEMBL72282
44311475
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CHEMBL72520
44311570
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CHEMBL72532
44311513
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CHEMBL72626
44311129
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CHEMBL72708
44311577
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CHEMBL72985
44314176
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CHEMBL73215
44311689
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CHEMBL73907
44314174
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CHEMBL74087
10327019
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CHEMBL74178
44311669
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CHEMBL74179
44311670
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CHEMBL74360
44314494
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CHEMBL74428
44314493
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CHEMBL74482
44314495
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CHEMBL74494
44314463
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CHEMBL74695
44314175
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CHEMBL74905
44314709
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CHEMBL75205
10051587
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CHEMBL75531
44314393
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CHEMBL75624
44315605
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CHEMBL75635
18397341
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CHEMBL75679
18397350
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CHEMBL75749
44315758
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CHEMBL75750
44315677
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CHEMBL75972
44315848
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CHEMBL76070
44315604
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CHEMBL76424
18397345
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CHEMBL76579
44314694
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CHEMBL76733
44315607
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CHEMBL76769
44314680
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CHEMBL76796
44315831
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CHEMBL76819
44315079
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CHEMBL76883
44315826
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CHEMBL76967
44315850
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CHEMBL77007
44315664
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CHEMBL77043
18397342
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CHEMBL77074
44315851
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CHEMBL77104
44314743
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CHEMBL77182
44315392
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CHEMBL77183
18397353
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CHEMBL77326
44315635
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CHEMBL77361
44315788
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CHEMBL77521
44315637
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CHEMBL77525
44315066
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CHEMBL77911
44315844
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CHEMBL77949
18397380
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CHEMBL77998
44315641
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CHEMBL78173
44315643
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CHEMBL78283
44315449
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CHEMBL78757
44315609
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CHEMBL79545
44315743
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CHEMBL79655
44315744
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CHEMBL79822
44315608
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CHEMBL80149
44316048
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CHEMBL80210
44316050
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CHEMBL80502
44316065
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CHEMBL80878
44316051
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CHEMBL80930
22010099
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CID 9850246
9850246
BindingDB
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CID 9850246
10347259
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CID 9850246
9807324
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CID 9918298
9853336
BindingDB
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CYCLOPENTANECARBOXYLIC ACID [1-(BENZOTHIAZOLE-2-CARBONYL)-4-GUANIDINO-BUTYL]-AMIDE
5289320
BindingDB
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[4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE
657077
DrugBank
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show
enlarge table
Synonyms:
Tryptase beta-2
Tryptase II
Tryptase-2
enlarge table
Similar targets:
Uniprot name
% Sequence similarity
% Sequence identity
TRY1_HUMAN
53.5
36.9
TRY2_MOUSE
53.3
38.3
TRY2_RAT
53.2
38.2
TRY2_CANFA
53.2
36.4
TRY1_CANFA
53
35.8
TRY1_BOVIN
52.9
35.7
CELA1_PIG
52.2
36.3
TRY1_SALSA
51.2
34
TRYP_PIG
50
34.6
CELA1_HUMAN
49.7
33.4
KLK3_MACFA
49.3
34.7
KLK3_MACMU
49
34.4
KLK6_HUMAN
48.8
33
KLK2_HUMAN
48.2
33.9
TRY2_SALSA
48.1
33.2
CTRA_BOVIN
47.8
34.1
CFAD_HUMAN
47.5
34.6
CMA1_HUMAN
47.1
30.9
KLK2_RAT
47.1
33
KLK1_HUMAN
47.1
34.3
VSP2_AGKAC
46.2
29.1
KLK3_HUMAN
46.2
32.6
CATG_HUMAN
45.9
30.5
CTRB1_HUMAN
45.6
33
CTR1_SOLIN
45
29.5
PRTN3_HUMAN
44.7
31.8
CAP7_HUMAN
44.7
31.3
CTRB2_HUMAN
44.6
32.3
TRYP_FUSOX
44.5
31.8
GRAB_HUMAN
43
30.2
enlarge table
Protein-Protein Interactions:
Uniprot name
Source
TRYB2_HUMAN
PMID 10500112,9521329
enlarge table
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