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Target Details
Name:
Peroxisome proliferator-activated receptor delta
Uniprot name:
PPARD_HUMAN
Accession Numbers:
A8K6J6
B6ZGS1
Q03181
Q5D1P0
Q7Z5K0
Q9BUD4
EC-Number:
-
Organism:
Homo sapiens
Human
PDB IDs:
1GWX
1Y0S
2AWH
2B50
2BAW
2ENV
2GWX
2J14
2Q5G
2ZNP
2ZNQ
3D5F
3DY6
3ET2
3GWX
3GZ9
KEGG Pathways:
show KEGG Pathways
Drugs:
Name
PubChem ID
Source
References
Interaction
(2S)-2-ethoxy-3-[4-[(E)-5-phenylpent-2-en-4-ynoxy]phenyl]propanoic Acid
11393977
BindingDB
-
show
2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid
3392731
BindingDB
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show
2-Bromohexadecanoic acid
82145
BindingDB
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show
2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
6102812
BindingDB
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show
3EA
9547900
BindingDB
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show
475479-34-6
10274777
BindingDB
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show
AC1MHWE1
3033829
BindingDB
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show
AC1NSKAH
5311242
BindingDB
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show
Asclepic acid
5282761
DrugBank
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show
BMS-687453
16725047
BindingDB
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CHEBI:515684
44443270
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CHEMBL101123
44331667
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CHEMBL102004
9895808
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CHEMBL104850
9866595
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CHEMBL106666
9870584
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CHEMBL1075665
46878644
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CHEMBL1075682
44626890
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CHEMBL1075683
44627190
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CHEMBL1075703
44626986
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CHEMBL1075704
44626988
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CHEMBL1075705
44626989
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CHEMBL1075706
44626990
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CHEMBL1075723
44627086
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CHEMBL1075724
44627087
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CHEMBL1075725
46878781
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CHEMBL1075732
44627948
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CHEMBL1075772
44627299
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CHEMBL1075835
44627305
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CHEMBL1075836
44627306
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CHEMBL1075856
44627300
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CHEMBL1075893
44627524
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CHEMBL1075894
44627417
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CHEMBL1075895
44627529
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CHEMBL1076151
44628049
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CHEMBL1076162
44626886
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CHEMBL1076163
44626887
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CHEMBL1076175
44626697
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CHEMBL1079382
44627946
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44627945
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CHEMBL1079488
44627298
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CHEMBL1079489
44627408
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44627525
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44627527
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44627303
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44628046
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44628047
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44627728
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44627842
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44627634
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44627731
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44628048
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CHEMBL1079752
44626981
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CHEMBL1079766
46879905
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CHEMBL1079821
44627192
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44627635
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CHEMBL1079910
44626480
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CHEMBL1079911
44626481
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CHEMBL1079925
44626799
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CHEMBL1079944
46879906
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46878727
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46878728
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44626892
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44627532
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44627533
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CHEMBL1079983
11663931
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44627302
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44627732
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44627412
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44627526
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CHEMBL1080032
44627733
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CHEMBL1080033
44627734
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CHEMBL1080108
44626800
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CHEMBL1080109
44626982
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CHEMBL1080140
46878729
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CHEMBL1080143
44626987
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44627636
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44627304
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44627413
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44627416
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44626585
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44626801
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CHEMBL1080312
46878777
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11585006
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44627941
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44627942
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46878645
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44626789
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16722365
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44627531
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44627188
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44626891
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45375886
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46879867
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44627528
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44627628
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44626791
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44626889
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44627735
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11678481
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44627944
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44626797
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44626884
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44626885
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44627083
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CHEMBL1081003
44627080
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CHEMBL1081004
44626798
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CHEMBL1081044
46878778
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CHEMBL1081045
46878779
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CHEMBL1081046
46878780
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CHEMBL1081206
44627843
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CHEMBL1081207
44627844
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CHEMBL1081223
44627084
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CHEMBL1081224
44627085
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CHEMBL1081241
46878843
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CHEMBL1081353
46880010
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CHEMBL1081354
46880011
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CHEMBL1081355
46880012
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CHEMBL1081380
44627845
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CHEMBL1081387
44627846
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CHEMBL1081391
44627191
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CHEMBL1081410
44627633
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CHEMBL1081424
44627409
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CHEMBL1081546
11649750
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CHEMBL1081591
44627410
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CHEMBL1081600
44628050
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CHEMBL1081601
44626477
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CHEMBL1081602
44627627
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CHEMBL1081603
44627301
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44626587
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44626696
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CHEMBL1081749
44627729
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44627730
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44627838
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44627297
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44627839
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44627840
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44626478
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44627079
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11547473
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44627841
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CHEMBL1081949
44627407
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CHEMBL1081950
44627078
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CHEMBL1081951
44626583
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CHEMBL1081962
44626888
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CHEMBL1081963
23656548
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CHEMBL1081964
44626689
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CHEMBL1082079
46880009
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44626586
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44627847
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CHEMBL1082114
44626479
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44627637
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CHEMBL1082116
44627411
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44627414
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CHEMBL1082118
44627415
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CHEMBL1082131
44626691
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CHEMBL1082137
44627943
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CHEMBL1085795
9803821
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46880049
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CHEMBL112790
44339547
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CHEMBL115463
18442898
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CHEMBL116540
10432525
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44345172
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9932804
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18442899
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44345265
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44345022
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44344313
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CHEMBL117918
9911749
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44345252
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44345196
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CHEMBL118577
44344272
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CHEMBL118753
44345278
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CHEMBL118756
9933537
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44344585
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11503588
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CHEMBL118939
10201545
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CHEMBL118976
10916251
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CHEMBL119066
9826417
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44344982
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10408561
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9822766
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9952559
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44345458
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9888528
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11111473
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12967684
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11101345
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24748569
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44476535
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44345030
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10743135
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52950020
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52948223
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10093355
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10371709
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10162008
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11339975
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11362757
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9933541
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44384639
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18702001
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11214000
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44385177
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11612623
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44385406
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10140233
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44388563
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44384466
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44385352
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11712873
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44389085
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10183245
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44389801
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10207244
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44411630
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CHEMBL392474
44439724
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CHEMBL392717
44434352
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CHEMBL392718
44434354
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CHEMBL392810
44440783
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CHEMBL392949
22280210
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CHEMBL392950
22280047
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CHEMBL392951
44432126
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CHEMBL393186
44432832
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CHEMBL393373
44432410
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CHEMBL393593
44439711
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CHEMBL393765
22504835
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CHEMBL393766
44432404
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CHEMBL393767
22504766
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CHEMBL393777
10027920
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CHEMBL393778
44439715
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CHEMBL393805
9980571
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CHEMBL393926
11774828
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CHEMBL393938
44434339
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CHEMBL393939
44434345
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CHEMBL393940
44434349
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CHEMBL393987
44432847
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CHEMBL393988
44432850
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CHEMBL394296
44440804
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44425855
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CHEMBL395924
21054984
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CHEMBL396154
44441216
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CHEMBL39687
22728012
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44425859
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44441214
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44425862
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CHEMBL397970
44425850
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CHEMBL398117
44440776
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CHEMBL398118
44440779
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CHEMBL39894
9845832
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CHEMBL399217
44434359
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CHEMBL399417
44434360
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CHEMBL400024
44439631
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CHEMBL400300
23661728
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CHEMBL401236
44434362
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CHEMBL402100
44446245
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CHEMBL402161
24890333
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CHEMBL402840
25243830
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CHEMBL404467
44446257
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CHEMBL40614
9932563
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CHEMBL412371
11408475
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-
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CHEMBL414868
16090857
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CHEMBL416794
9844286
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CHEMBL418874
44344888
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CHEMBL419768
44345183
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CHEMBL420441
44327180
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CHEMBL420973
44320978
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CHEMBL421729
44321548
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CHEMBL424674
44409274
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CHEMBL424957
44388167
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CHEMBL425254
16090859
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CHEMBL425431
16007090
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-
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CHEMBL425666
44424582
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-
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CHEMBL425725
10005230
BindingDB
-
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CHEMBL425766
11627288
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-
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CHEMBL425945
44411581
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-
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CHEMBL426269
11408502
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-
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CHEMBL426371
44424584
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-
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CHEMBL426483
44407224
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CHEMBL426592
10113686
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-
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CHEMBL427040
44412195
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-
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CHEMBL427071
44424588
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CHEMBL427299
44385405
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-
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CHEMBL427701
44440790
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CHEMBL427890
44446263
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-
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CHEMBL428574
44440782
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CHEMBL429824
44440786
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CHEMBL430182
44439725
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CHEMBL430970
12017338
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CHEMBL433306
44316349
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CHEMBL433316
44316114
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CHEMBL435343
44388210
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CHEMBL435517
10279905
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CHEMBL435704
17894227
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CHEMBL435715
44383664
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CHEMBL437364
44432854
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CHEMBL437479
16090879
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CHEMBL443218
44331751
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CHEMBL443243
42625871
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CHEMBL444175
42625955
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CHEMBL445921
44389098
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CHEMBL446489
42625954
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CHEMBL447190
10297427
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-
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CHEMBL448996
42626029
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CHEMBL450050
42625799
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CHEMBL450774
42625795
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CHEMBL451216
42625796
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-
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CHEMBL451681
42625875
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CHEMBL452054
25165638
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CHEMBL452299
44561770
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CHEMBL454508
42625720
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CHEMBL454651
11374318
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CHEMBL454678
11225048
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CHEMBL455126
44561816
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CHEMBL455127
25211572
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CHEMBL455130
25166738
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CHEMBL455157
11442294
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CHEMBL455158
11271211
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CHEMBL455957
24890336
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CHEMBL456355
44587801
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-
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CHEMBL456752
24890334
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CHEMBL456753
24890509
BindingDB
-
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CHEMBL456973
44587736
BindingDB
-
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CHEMBL456974
44587737
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-
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CHEMBL457062
11227195
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-
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CHEMBL457405
44587769
BindingDB
-
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CHEMBL457623
44587770
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-
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CHEMBL459466
25165359
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-
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CHEMBL460073
25165162
BindingDB
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CHEMBL460278
11784860
BindingDB
-
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CHEMBL461145
11329304
BindingDB
-
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CHEMBL461378
25166740
BindingDB
-
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CHEMBL461379
25166743
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CHEMBL461533
11166818
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CHEMBL461944
25166956
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CHEMBL462378
25164959
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CHEMBL462554
11306745
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CHEMBL462580
11374680
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CHEMBL462982
24890510
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CHEMBL470322
11237218
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CHEMBL471533
11283113
BindingDB
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CHEMBL472071
16046722
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CHEMBL472399
11179502
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CHEMBL472571
11190667
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CHEMBL473096
44562841
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CHEMBL473299
44562842
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CHEMBL473300
11259787
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CHEMBL473717
11352791
BindingDB
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CHEMBL482993
44591802
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CHEMBL484330
44591815
BindingDB
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CHEMBL484606
44591752
BindingDB
-
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CHEMBL484725
44591803
BindingDB
-
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CHEMBL484962
44591751
BindingDB
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CHEMBL485155
15984029
BindingDB
-
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CHEMBL485179
16046718
BindingDB
-
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CHEMBL492324
42625798
BindingDB
-
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CHEMBL492519
42625721
BindingDB
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CHEMBL492534
11203145
BindingDB
-
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CHEMBL492535
42626028
BindingDB
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CHEMBL494142
42625956
BindingDB
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CHEMBL501155
42625797
BindingDB
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CHEMBL50143
9958289
BindingDB
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CHEMBL50259
44296114
BindingDB
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CHEMBL50572
44296271
BindingDB
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CHEMBL506730
42625953
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CHEMBL50680
44296211
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CHEMBL507477
44561817
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CHEMBL50755
44296435
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CHEMBL508163
42626030
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CHEMBL50885
44296489
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CHEMBL509369
25165639
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CHEMBL509680
11271514
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CHEMBL50984
12017347
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CHEMBL510180
25165560
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CHEMBL511989
16046721
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CHEMBL513035
11155783
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CHEMBL513594
11167613
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CHEMBL514256
44587738
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CHEMBL514264
25071332
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CHEMBL515667
11376123
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CHEMBL51603
44296048
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CHEMBL516510
11432162
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CHEMBL516511
11477433
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CHEMBL516824
11247908
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CHEMBL516964
11167738
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CHEMBL517436
44561969
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CHEMBL518348
11374679
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CHEMBL518499
25166741
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CHEMBL519854
44591830
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CHEMBL520508
16222636
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CHEMBL521007
10141607
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CHEMBL522366
42625952
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CHEMBL523306
25181476
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CHEMBL523334
42625874
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CHEMBL52426
22458906
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CHEMBL52633
9829139
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CHEMBL53688
44296529
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CHEMBL53746
22459152
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CHEMBL54097
44296127
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CHEMBL54197
22458923
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CHEMBL561006
45269453
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CHEMBL562786
45273780
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CHEMBL590983
46233071
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CHEMBL590984
46233072
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CHEMBL601222
46233070
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CHEMBL601678
46232959
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CHEMBL601861
46233040
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CHEMBL602263
46233001
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CHEMBL602468
46233002
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CHEMBL602469
46233003
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CHEMBL602670
46233038
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CHEMBL606422
46233039
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CHEMBL606425
46232960
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CHEMBL76676
10410878
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CHEMBL78442
44316903
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CHEMBL78523
11704026
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CHEMBL78529
11178916
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CHEMBL79426
11431192
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CHEMBL80301
44316506
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CHEMBL80364
10387634
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CHEMBL80671
44316521
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CHEMBL80772
44316348
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CHEMBL80791
44316880
BindingDB
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CHEMBL80905
44316591
BindingDB
-
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CHEMBL81208
11775099
BindingDB
-
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CHEMBL81248
10004270
BindingDB
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CHEMBL81592
11271060
BindingDB
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CHEMBL82034
10139247
BindingDB
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CHEMBL82193
11340991
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CHEMBL82602
10276539
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CHEMBL86688
44321441
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CHEMBL86817
44321490
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CHEMBL87307
44321572
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CHEMBL87380
44321573
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CHEMBL87928
44321284
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CHEMBL89152
44320897
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-
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CHEMBL89996
44321462
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-
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CHEMBL92130
21341898
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-
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CHEMBL94397
44327220
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-
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CHEMBL94496
22459117
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-
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CHEMBL94716
44327273
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CHEMBL96107
44327507
BindingDB
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CHEMBL96143
44327416
BindingDB
-
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CHEMBL96451
22459015
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CHEMBL96758
44327231
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CHEMBL97529
22459114
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CID 10026030
10320822
BindingDB
-
show
CID 10050194
10050194
BindingDB
-
show
CID 10096476
11282914
BindingDB
-
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CID 10233572
11169884
BindingDB
-
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CID 10254209
10254209
BindingDB
-
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CID 11248512
11248512
BindingDB
-
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CID 11248512
10005136
BindingDB
-
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CID 11386220
11386220
BindingDB
-
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CID 9848083
11260214
BindingDB
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CID 9935197
9935197
BindingDB
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Compound P
6603901
BindingDB
-
show
Eicosapentaenoic acid
446284
DrugBank
-
show
Farglitazar
170364
BindingDB
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show
Fenofibrate
64929
BindingDB
-
show
G3295_SIGMA
9934458
BindingDB
-
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GSK-516
9803963
BindingDB
-
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GW-9578
9870304
BindingDB
-
show
GW2433
1517
BindingDB
-
show
HEPTYL-BETA-D-GLUCOPYRANOSIDE
448173
DrugBank
-
show
KRP-297
151183
BindingDB
-
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LY-518674
9909438
BindingDB
-
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LY-929
9890585
BindingDB
-
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MRL-I
10207241
BindingDB
-
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Naveglitazar
9888484
BindingDB
-
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NSC367464
339720
BindingDB
-
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Pirinixic acid
5694
BindingDB
-
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Rosigilitazone
77999
BindingDB
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Sklerofibrat
39042
BindingDB
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STK136733
4518233
BindingDB
-
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STK195491
1285388
BindingDB
-
show
Sulindac
5352
DrugBank
-
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Telmisartan
65999
BindingDB
-
show
Treprostinil
54786
DrugBank
-
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trisubstituted isoxazole, 1
11497604
BindingDB
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show
TZD-18
9827261
BindingDB
-
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YPA
446758
BindingDB
-
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ZINC01535302
6992117
BindingDB
-
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[3H]nTZD3
11753952
BindingDB
-
show
enlarge table
Synonyms:
NUC1
NUCI
Nuclear hormone receptor 1
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor delta
PPAR-beta
PPAR-delta
enlarge table
Similar targets:
Uniprot name
% Sequence similarity
% Sequence identity
PPARA_HUMAN
74.5
60.6
Q53EW1_HUMAN
65.9
51
PPARG_HUMAN
62.6
48.4
PPARG_MACMU
62.6
48.4
Q86WD1_HUMAN
54.4
42.1
THA_SHEEP
42.8
27
RARG_HUMAN
41.9
25.5
RARB_HUMAN
39.8
24.3
RARA_HUMAN
39.3
25.6
THB_HUMAN
39.3
25.4
Q6I9R7_HUMAN
39.3
25.6
RORA_MOUSE
39.2
24
NR1I2_MOUSE
39
21.8
B6ZGR8_HUMAN
39
23.4
RXRA_MOUSE
38.7
25.8
RARB_MOUSE
38.6
23.2
RXRA_HUMAN
38.5
25.5
VDR_HUMAN
38.4
23.3
NR1I2_HUMAN
38.3
23.5
VDR_RAT
37.7
23.7
NR1H2_HUMAN
37.1
26.1
Q5F0P8_HUMAN
37.1
24.6
NR1H4_HUMAN
37
23.9
ERR3_MOUSE
35.8
22.6
ERR3_HUMAN
35.8
22.6
ERR3_RAT
35.8
22.6
THA_HUMAN
35.7
21.8
Q569H8_HUMAN
35.1
23.9
ERR1_HUMAN
35.1
23.9
HNF4A_RAT
35
20.2
enlarge table
Protein-Protein Interactions:
Uniprot name
Source
RANB9_HUMAN
PMID 15604093
PROX1_HUMAN
2 PMIDs
PPARD_HUMAN
3 PMIDs
PEBP1_HUMAN
4 PMIDs
NRIP1_HUMAN
5 PMIDs
MINT_HUMAN
6 PMIDs
GA45G_HUMAN
7 PMIDs
enlarge table
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